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Low-frequency repetitive transcranial magnetic stimulation on Parkinson motor function: a meta-analysis of randomised controlled trials

Published online by Cambridge University Press:  16 January 2015

HongCan Zhu ,
ZhaoMing Lu ,
YiTing Jin ,
XiaoJia Duan ,
JunFang Teng  and
DongXiao Duan
HongCan Zhu
Affiliation:
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, PR China
ZhaoMing Lu
Affiliation:
School of Pharmaceutical Sciences, Zhengzhou University, Henan, PR China
YiTing Jin
Affiliation:
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, PR China
XiaoJia Duan
Affiliation:
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, PR China
JunFang Teng
Affiliation:
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, PR China
DongXiao Duan*
Affiliation:
Department of Physiology, Basic Medical College, Zhengzhou University, Henan, PR China
*
Associate Professor DongXiao Duan, Basic Medical College, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 45001, PR China.Tel: +86-371-67783111; Fax: +86-371-67783222; E-mail: [email protected]
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Abstract

Objectives

Previous studies have demonstrated inconsistent findings regarding the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) in treating motor symptoms of Parkinson’s disease (PD). Therefore, this meta-analysis was conducted to assess the efficacy of low-frequency rTMS.

Methods

A comprehensive literature search (including PubMed, CCTR, Embase, Web of Science, CNKI, CBM-disc, NTIS,EAGLE, Clinical Trials, Current Controlled Trials, International Clinical Trials Registry) was conducted dating until June 2014. The key search terms (‘Parkinson’, ‘PD’, ‘transcranial magnetic stimulation’, ‘TMS’, ‘RTMS’ and ‘noninvasive brain stimulation’) produced eight high-quality randomised controlled trials (RCT) of low-frequency rTMS versus sham stimulation.

Results

These eight studies, composed of 319 patients, were meta-analysed through assessment of the decreased Unified Parkinson’s Disease Rating Scale (UPDRS part III) score. Pooling of the results from these RCTs yielded an effect size of −0.40 (95%CI=−0.73 to −0.06, p<0.05) in UPDRS part III, which indicated that low-frequency rTMS could have 5.05 (95%CI=−1.73 to −8.37) point decrease in UPDRS part III score than sham stimulation.

Discussion

Low-frequency rTMS had a significant effect on motor signs in PD. As the number of RCTs and PD patients included here was limited, further large-scale multi-center RCTs were required to validate our conclusions.

Keywords

Parkinson’s diseasePDrepetitive transcranial magnetic stimulationrTMSTMS
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 27 , Issue 2 , April 2015 , pp. 82 - 89
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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