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Influence of NRGN rs12807809 polymorphism on symptom severity in individuals with schizophrenia in the Han population but not the Zhuang population of south China

Published online by Cambridge University Press:  05 March 2015

Li Su ,
Jianxiong Long ,
Runde Pan ,
Xinfeng Xie ,
Xixiang Mao ,
Yang Zhou ,
Qiang Chen  and
Bo Wei
Li Su
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Jianxiong Long
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Runde Pan
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Xinfeng Xie
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Xixiang Mao
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Yang Zhou
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Qiang Chen*
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Bo Wei
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
*
Qiang Chen, Guangxi Brain Hospital, Liuzhou, Guangxi, China.Tel: +860 772 311 5137; Fax: +860 772 311 5137; E-mail: [email protected]
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Abstract

Background

NRGN is one of the most promising candidate genes for schizophrenia based on function and position. Therefore, this study aimed to examine the genetic association of this polymorphism with schizophrenia in the Zhuang and Han populations of south China.

Subjects and methods

A total of 282 patients (188 Han and 94 Zhuang) and 282 healthy subjects (188 Han and 94 Zhuang) were recruited. Of these, 246 schizophrenia patients underwent an assessment of psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS). A TaqMan genotyping assay method was used to determine the genotypes.

Results

We did not find a significant association of rs12807809 polymorphism with schizophrenia in the total pooled samples, or in the separate ethnic groups. However, in Han schizophrenia patients, quantitative data analyses showed that the CC genotype of the rs12807809 polymorphism was associated with PANSS aggression subscale score and activation subscale score. Furthermore, carriers of the C allele of rs12807809 polymorphism among Han schizophrenia patients had higher scores of general, activation, depression, aggression, and global symptoms than the T allele carriers.

Conclusion

In conclusion rs12807809 polymorphism may not contribute to the risk of schizophrenia but influence the clinical symptoms of schizophrenia in the Han population.

Keywords

NRGNpolymorphismrs12807809schizophrenia
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 4 , August 2015 , pp. 221 - 227
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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Footnotes

a

Co-first author

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