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Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker

Published online by Cambridge University Press:  14 July 2016

Esra Soydaş Akyol ,
Yakup Albayrak ,
Nurkan Aksoy ,
Başak Şahin ,
Murat Beyazyüz ,
Murat Kuloğlu  and
Kenji Hashimoto
Esra Soydaş Akyol
Affiliation:
Department of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey
Yakup Albayrak*
Affiliation:
Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
Nurkan Aksoy
Affiliation:
Department of Biochemistry, Yenimahalle Education and Research Hospital, Ankara, Turkey
Başak Şahin
Affiliation:
Department of Psychiatry, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Murat Beyazyüz
Affiliation:
Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
Murat Kuloğlu
Affiliation:
Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey
Kenji Hashimoto
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
*
Yakup Albayrak, Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Namık Kemal Universitesi Uygulama ve Arastırma Hastanesi Psikiyatri Poliklinigi, Yıl mah, Tekirdag, Turkey. Tel: +90 505 635 5434; Fax: +90 282 250 5924; E-mail: [email protected]
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Abstract

Objective

The product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed glutamatergic transmission and increased reactive oxygen species. Only one pilot study by Lin et al. has investigated the potential role of serum G72 protein levels as a biomarker for schizophrenia. In this study, we aimed to compare serum G72 protein levels between patients with schizophrenia and healthy controls, and to retest the results of the previous pilot study.

Materials and methods

In total, 107 patients with a diagnosis of schizophrenia according to the inclusion and exclusion criteria and 60 age–sex-matched healthy controls were included in the study. The groups were compared regarding serum G72 protein levels.

Results

The mean serum G72 protein values were 495.90±152.03 pg/ml in the schizophrenia group and 346.10±102.08 pg/ml in the healthy control group. The mean serum G72 protein level was significantly increased in the schizophrenia group compared with the healthy control group (t=−3.89, p<0.001). A receiver operating characteristics analysis was performed to compare the schizophrenia and healthy control groups. It was determined that the cut-off value was 141.51 pg/ml with a sensitivity of 0.991 and a specificity of 0.821.

Conclusion

We suggest that serum G72 protein levels may represent a candidate biomarker for schizophrenia and have confirmed the results of the previous preliminary study. Additional studies with larger sample sizes and the inclusion of first episode schizophrenia patients are required to clarify the reliability and validity of serum G72 protein levels as a biomarker for schizophrenia.

Keywords

biomarkerG72glutamateschizophrenia
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 29 , Issue 2 , April 2017 , pp. 80 - 86
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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