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Immunological aspects of bipolar disorder

Published online by Cambridge University Press:  18 September 2015

R.W. Kupka ,
M.H.J. Hillegers ,
W.A. Nolen ,
N. Breunis  and
H.A. Drexhage
R.W. Kupka*
Affiliation:
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands Stanley Foundation Bipolar Network
M.H.J. Hillegers
Affiliation:
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
W.A. Nolen
Affiliation:
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands Stanley Foundation Bipolar Network
N. Breunis
Affiliation:
Department of Immunology, Erasmus University Rotterdam, The Netherlands
H.A. Drexhage
Affiliation:
Department of Immunology, Erasmus University Rotterdam, The Netherlands
*
Altrecht Institute for Mental Health Care, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands E-mail [email protected]
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Abstract

Introduction: Significant changes in immune function have been found in mood disorders. Controlled studies in bipolar disorder concerning cell-mediated immunity and thyroid autoimmunity are reviewed, and presented together with preliminary findings from our own ongoing study.

Method: Using Medline and other sources, 14 controlled studies as well as some other relevant studies were found.

Results: Bipolar disorder is associated with an acute phase response and activation of the cell-mediated immune system, and with an increased prevalence of antithyroid autoantibodies.

Conclusion: Changes in immune function, in connection with neuroendocrine changes, may provide new hypotheses for the pathophysiology of mood disorders.

Keywords

Bipolar disordercell-mediated immunitythyroid autoimmunitylithium
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 86 - 90
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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References

1.Dunn, AJ. Interactions between the nervous system and the immune system. In: Bloom, FE. Kupfer, DJ (eds.). Psychopharmacology: The Fourth Generation of Progress. New York. Raven Press, 1995, pp 719–731.Google Scholar
2.Hart, BL. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988:12:123–137.CrossRefGoogle ScholarPubMed
3.Connor, TJ. Leonard, BE. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci 1998:62:583–606.CrossRefGoogle ScholarPubMed
4.Maes, M. The immune pathophysiology of major depression. In Honig, A, van Praag, HM. (eds.). Depression: Neurobiological. Psychopathological and Therapeutic Advances. London. John Wilev & Sons. 1997. pp 197–215.Google Scholar
5.Kronfol, Z. House, JD. Immune function in mania. Biol Psychiatry 1988:24:341–343.CrossRefGoogle ScholarPubMed
6.Rapaport, MH. Immune parameters in cuthymic bipolar patients and normal volunteers. J Affect Disord 1994:32:149–156.CrossRefGoogle Scholar
7.Maes, M. Bosnians, E. Calabrese, J. et al.Interlcukin-2 and interleu-kin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers. J Psychiatr Res 1995:29:141–152.CrossRefGoogle Scholar
8.Maes, M. Delange, J. Ranjan, R, et al.Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs. Psychiatr Res 1997:66:1–11.CrossRefGoogle ScholarPubMed
9.Hornig, M. Goodman, DBP. Kamoun, M. Amsterdam, JD. Positive and negative acute phase proteins in affective subtypes. J Affect Disord 1998:49:9–18.CrossRefGoogle ScholarPubMed
10.Sourlingas, TG. Issidorides, MR. Havaki, S. et al.Peripheral blood lymphocytes of bipolar affective patients have a histone synthetic profile indicative of an active cell state. Progr Neuro-Psychopharmacol Biol Psychiatry 1998:22:81–96.CrossRefGoogle ScholarPubMed
11.Rapaport, MH. Guylai, L. Whybrow, PC. Immune parameters in rapid cycling bipolar patients before and after lithium treatment. J Psychiatric Res 1999:33:335–340.CrossRefGoogle ScholarPubMed
12.Tsai, S. Chen, K. Yang, et al.Activation of indices of cell-mediated immunity in bipolar mania. Biol Psychiatry 1999;45:989–994.CrossRefGoogle ScholarPubMed
13.Hendrick, V. Altshuler, L. Whybrow, P. Psychoneuroendocrinology of mood disorders. The hypothalamic-pituitary-thyroid axis. Psychiatr Clin North Am 1998:21:277–292.CrossRefGoogle ScholarPubMed
14.Kleiner, J. Altshuler, L. Hendrick, V. Hershman, JM. Lithium-induced subclinical hypothyroidism: review of the literature and guidelines for treatment. J Clin Psychiatry 1999; 60:249–255.CrossRefGoogle ScholarPubMed
15.Myers, DH. Carter, RA. Burns, BH. et al.A prospective study of the effects of lithium on thyroid function and on the prevalence of antithyroid antibodies. Psychol Med 1985:15:55–61.CrossRefGoogle ScholarPubMed
16.Wilson, R. McKillop, JH. Crocket, GT.et al.The effect of lithium therapy on parameters thought to be involved in the development of autoimmune thyroid disease. Clin Endocrinol 1991:34:357–361.CrossRefGoogle Scholar
17.Haggerty, JJ Jr, Evans, DL. Golden, RNet al.The presence of antithyroid anticodies in patiens with affective and non-affective psychiatric disorders. Biol Psychiatry 1990:27:51–60.CrossRefGoogle Scholar
18.Haggerty, JJ Jr.Silva, SG. Marquardt, Met al.Prevalence of antithyroid antibodies in mood disorders. Depress Anxiety 1997:5:91–96.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
19.Bartalcna, L. Pellegrini, L. Meschi, M, et al.Evaluation of thyroid function in patients with rapid-cycling and non-rapid-cycling bipolar disorder. Psychiatr Res 1990:34:13–17.CrossRefGoogle Scholar
20.Hornig, M. Amsterdam, JD. Kamoun, Met al.Autoantibody disturbances in affective disorders: a function of age and gender? J Affect Disord 1999:55:29–37.CrossRefGoogle ScholarPubMed
21.Bochetta, A. Bernardi, F. Pedditzi, Met al.Thyroid abnormalities during lithium treatment. Acta Psychiatr Scand 1991:83:193–198.CrossRefGoogle Scholar
22.Bocchetta, A. Bemardi, F. Burrai, Cet al.The course of thyroid abnormalities during lithium treatment: a two-year follow-up study. Acta Psychiatr Scand 1992:86:38–41.CrossRefGoogle ScholarPubMed
23.Bochetta, A. Cherchi, A, Lovisclli, Aet al.Six-year follow-up of thyroid function during lithium treatment. Acta Psychiatr Scand 1996:94:45–48.CrossRefGoogle Scholar
24.Bochetta, A. Ardau, R. Burrai, Cet al.Ten-year follow-up of lithium patients with special reference to thyroid function. Poster abstract. Bipolar Disord 1999:1 (suppl 1):25.Google Scholar
25.Oomen, HAPC. Schipperijn, AJM. Drexhage, HA. The prevalence of affective disorder and in particular of a rapid cycling of bipolar disorder in patients with abnormal thvroid function tests. Clin Endocrinol 1996:45:215–223.CrossRefGoogle Scholar
26.Lieb, J. Lithium and immune function. Med Hypoth 1987:23:73–93.CrossRefGoogle ScholarPubMed
27.Rvbakowski, JK. The effect of lithium on the immune system. Hum Psychopharmacol Clin Exp 1999:14:345–353.3.0.CO;2-T>CrossRefGoogle Scholar
28.Macs, M, Song, C. Lin, A. et al.In vitro immunorcgulatory effects of lithium in healthy volunteers. Psychopharmacol 1999:143:401–407.Google Scholar
29.Haack, M. Hinze-Selch, D. Fenzel, T. et al.Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatr Res 1999:33:407–418.CrossRefGoogle ScholarPubMed