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Immune disturbances in severely depressed patients: relationship with Cortisol secretion

Published online by Cambridge University Press:  18 September 2015

M. Maes ,
E. Bosmans ,
E. Suy ,
B. Minner  and
J. Rausn
M. Maes
Affiliation:
Van het Psychiatrisch Centrum. Munsterbilzen
E. Bosmans
Affiliation:
het Dr. L. Willems Instituut. Diepenbeek
E. Suy
Affiliation:
Van het Psychiatrisch Centrum. Munsterbilzen
B. Minner
Affiliation:
Van het Psychiatrisch Centrum. Munsterbilzen
J. Rausn
Affiliation:
het Dr. L. Willems Instituut. Diepenbeek
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Abstract

The mitogen induced lymphocyte responses were measured in 33 depressed patients categorized according to the DSM-III into minor (300.40, 309.00), simple major (296.X2) and major depression with melancholia and/or psychotic features (296.X3, 296.X4). Three distinct mitogens were used, i.e. phytohemaglutinin (PHA), pokeweed mitogen (PWM) and concanavalin A (CON A). We found that major depressives with associated features showed significantly lower mitogen induced lymphocyte responses to PHA and PWM as compared to all other depressed patients. The severity of illness was significantly inversely related to the lymphocyte responses to PHA. Cortisol nonsuppressors exhibited significantly lower PHA and PWM induced lymphocyte responses as compared with suppressors. There were significant and negative correlations between the postdexamethasone Cortisol values and the PHA and PWM stimulated lymphocyte responses.

Keywords

depressionmitogen-induced-lymphocyte responsesDSTdepressieDSTlymfocyten transforma-tie test
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 2 , Issue 1 , March 1990 , pp. 3 - 7
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1990

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