Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-23T08:59:02.226Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of post-training modafinil administration in a discriminative avoidance task in mice

Published online by Cambridge University Press:  23 March 2015

Helaine Arrais Fernandes ,
Karina Agustini Zanin ,
Camilla de Lima Patti ,
Leonardo Brito Lopes-Silva ,
Carolina Souza Bizerra ,
Lia Rita Azeredo Bittencourt ,
Sergio Tufik  and
Roberto Frussa-Filho
Helaine Arrais Fernandes
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Karina Agustini Zanin
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Camilla de Lima Patti*
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil
Leonardo Brito Lopes-Silva
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Carolina Souza Bizerra
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil
Lia Rita Azeredo Bittencourt
Affiliation:
Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Sergio Tufik
Affiliation:
Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Roberto Frussa-Filho
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
*
Camilla L. Patti, Departamento de Farmacologia – UNIFESP, Rua Botucatu, 862, Ed. Leal Prado, 1º andar, 04023062, São Paulo, SP, Brazil. Tel/Fax: +55 011 5549 4122; E-mail: [email protected]; [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Although the cognitive-enhancing abilities after modafinil have been demonstrated, its effects on memory consolidation remain overlooked. We investigated the effects of repeated modafinil administration on consolidation of a discriminative avoidance task.

Methods

Mice were trained in the plus-maze discriminative avoidance task. After training, mice received intraperitonial modafinil (doses of 32, 64 or 128 mg/kg). Animals were treated for more 9 consecutive days; 30 min after the last injection, testing was performed. In addition, the effects of 32 mg/kg modafinil on consolidation at different time points were examined.

Results

The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion. Still, modafinil post-training administration at 1 or 2 h impaired memory persistence.

Conclusions

Modafinil impaired memory consolidation in a dose- and time-dependent fashion.

Keywords

anxietylocomotionmemory consolidationmicemodafinil
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 27 , Issue 4 , August 2015 , pp. 235 - 241
Check for updates
Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

The first two authors contributed equally to this work.

†

In memoriam.

References

1.Ferraro, L, Antonelli, T, O’Connor, WT, Tanganelli, S, Rambert, FA, Fuxe, K. The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neurosci Lett 2008;253:15–18.Google Scholar
2.Kraft, GH, Bowen, J. Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study. Neurology 2005;65:1995–1997.CrossRefGoogle Scholar
3.Turner, DC, Clark, L, Pomarol-Clotet, E, Mckenna, P, Robbins, TW, Sahakian, BJ. Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 2004;29:1363–1373.CrossRefGoogle ScholarPubMed
4.Taylor, FB, Russo, J. Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults. J Child Adolesc Psychopharmacol 2000;10:311–320.CrossRefGoogle ScholarPubMed
5.Joos, L, Docx, L, Schmaal, L, Sabbe, BG, Dom, G. Modafinil in psychiatric disorders: the promising state reconsidered. Tijdschr Psychiatr 2010;52:763–773.Google ScholarPubMed
6.Cakic, V. Smart drugs for cognitive enhancement: ethical and pragmatic considerations in the era of cosmetic neurology. J Med Ethics 2009;35:611–615.CrossRefGoogle ScholarPubMed
7.Béracochéa, D, Celerier, A, Peres, M, Piérard, C. Enhancement of learning processes following an acute modafinil injection in mice. Pharmacol Biochem Behav 2003;76:473–479.CrossRefGoogle ScholarPubMed
8.Béracochéa, D, Cagnard, B, Celerier, A, Merrer, J, Peres, M, Piérard, C. First evidence of a delay-dependent working memory – enhancing effect of modafinil in mice. Neuroreport 2001;12:375–378.CrossRefGoogle ScholarPubMed
9.Béracochéa, D, Celerier, A, Borde, N, Valleau, M, Peres, M, Piérard, C. Improvement of learning processes following chronic systemic administration of modafinil in mice. Pharmacol Biochem Behav 2002;73:723–728.CrossRefGoogle ScholarPubMed
10.Shuman, T, Wood, SC, Anagnostaras, SG. Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning. Behav Neurosci 2009;123:257–266.CrossRefGoogle ScholarPubMed
11.Fernandes, HA, Zanin, KA, Patti, CLet al. Inhibitory effects of modafinil on emotional memory in mice. Neuropharmacol 2013;64:365–370.CrossRefGoogle ScholarPubMed
12.Patti, CL, Zanin, KA, Sanday, Let al. Effects of sleep deprivation on memory in mice: role of state-dependent learning. Sleep 2010;33:1669–1679.CrossRefGoogle ScholarPubMed
13.Gulick, D, Gould, TJ. Nicotine acts in the anterior cingulate, but not dorsal or ventral hippocampus, to reverse ethanol-induced learning impairments in the plus-maze discriminative avoidance task. Addict Biol 2011;16:176–188.CrossRefGoogle ScholarPubMed
14.Zanin, KA, Patti, CL, Sanday, Let al. Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task. Psychopharmacology (Berl) 2013;226:459–474.CrossRefGoogle ScholarPubMed
15.Carvalho, RC, Patti, CL, Takatsu-Coleman, ALet al. Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments. Brain Res 2006;29:179–183.CrossRefGoogle Scholar
16.Silva, RH, Bellot, RG, Vital, MA, Frussa-Filho, R. Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice. Psychopharmacology (Berl) 1997;129:322–328.Google ScholarPubMed
17.Claro, FT, Silva, RH, Frussa-Filho, R. Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia. Physiol Behav 1999;67:551–554.CrossRefGoogle ScholarPubMed
18.Wuo-Silva, R, Fukushiro, DF, Borçoi, ARet al. Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study. Addict Biol 2011;16:565–579.CrossRefGoogle ScholarPubMed
19.Burgos, H, Castillo, A, Flores, Oet al. Effect of modafinil on learning performance and neocortical long-term potentiation in rats. Brain Res Bull 2010;83:238–244.CrossRefGoogle ScholarPubMed
20.Bekinschtein, P, Cammarota, M, Igaz, LMet al. Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Neuron 2007;53:261–277.CrossRefGoogle ScholarPubMed
21.Bekinschtein, P, Cammarota, M, Katche, Cet al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A 2008;105:2711–2716.CrossRefGoogle ScholarPubMed
22.Bekinschtein, P, Katche, C, Slipczuk, Let al. Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures. Neurotox Res 2010;18:377–385.CrossRefGoogle ScholarPubMed
23.Mignot, E, Nishino, S, Guilleminault, C, Dement, WC. Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 1994;17:436–437.CrossRefGoogle Scholar
24.Zolkowska, D, Jain, R, Rothman, RBet al. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther 2009;329:738–746.CrossRefGoogle ScholarPubMed
25.Andersen, ML, Kessler, E, Murnane, KS, McClung, JC, Tufik, S, Howell, LL. Dopamine transporter-related effects of modafinil in rhesus monkeys. Psychopharmacology (Berl) 2010;210:439–448.CrossRefGoogle ScholarPubMed
26.Volkow, ND, Fowler, JS, Logan, Jet al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 2009;301:1148–1154.CrossRefGoogle ScholarPubMed
27.TM, Jay. Dopamine: a potential substrate for synaptic plasticity and memory mechanisms. Prog Neurobiol 2003;69:375–390.Google Scholar
28.O’Carroll, CM, Martin, SJ, Sandin, J, Frenguelli, B, Morris, RG. Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. Learn Mem 2006;13:760–769.CrossRefGoogle ScholarPubMed