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Effect of vitamin E on cisplatin-induced memory impairment in male rats

Published online by Cambridge University Press:  15 October 2020

Masoud Hosseinzadeh ,
Amir Alizadeh ,
Parnian Heydari ,
Marzieh Kafami Open the ORCID record for Marzieh Kafami [Opens in a new window] ,
Mahmoud Hosseini ,
Farimah Beheshti ,
Narges Marefati  and
Moustafa Ghanbarabadi
Masoud Hosseinzadeh
Affiliation:
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Amir Alizadeh
Affiliation:
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Parnian Heydari
Affiliation:
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Marzieh Kafami*
Affiliation:
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Mahmoud Hosseini
Affiliation:
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Farimah Beheshti
Affiliation:
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Narges Marefati
Affiliation:
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Moustafa Ghanbarabadi
Affiliation:
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
*
Author for correspondence: Marzieh Kafami, E-mail: [email protected]
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Abstract

Objective:

Neurotoxicity is an adverse effect caused by cisplatin due to inflammation and oxidative stress in the central nervous system. The present study aimed to assess the effects of vitamin E injection on the learning and memory of rats with cisplatin-induced cognitive impairment.

Methods:

Male rats were administered with cisplatin (2 mg/kg/7 day; intraperitoneally [i i.p.]) and/or vitamin E (200 mg/kg/7 day; i.p.) for 1 week, and the control group received saline solution. Spatial memory was evaluated using Morris water maze (MWM). In addition, the hippocampal concentrations of malondialdehyde (MDA), thiol, and superoxide dismutase (SOD) were measured using biochemical methods.

Results:

According to the findings, cisplatin significantly increased the escape latency, while decreasing the time spent and travelled pathway in the target quadrant on the final trial day compared to the control group. Furthermore, pre-treatment with vitamin E significantly reversed all the results in the spatial memory test. The biochemical data indicated that vitamin E could decrease MDA activity and increase thiol and SOD activity compared to the control group.

Conclusion:

According to the results, vitamin E could improve cisplatin-induced memory impairment possibly through affecting the hippocampal oxidative status.

Keywords

vitamin Ecisplatinmemorymalondialdehydesuperoxide dismutase
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 33 , Issue 1 , February 2021 , pp. 43 - 48
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Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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