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Distinctive neuropsychological profiles differentiate patients with functional memory disorder from patients with amnestic-mild cognitive impairment

Published online by Cambridge University Press:  17 July 2017

Sarah J Wakefield ,
Daniel J Blackburn Open the ORCID record for Daniel J Blackburn [Opens in a new window] ,
Kirsty Harkness ,
Aijaz Khan ,
Markus Reuber  and
Annalena Venneri
Sarah J Wakefield
Affiliation:
Department of Neuroscience, University of Sheffield, UK
Daniel J Blackburn
Affiliation:
Department of Neuroscience, University of Sheffield, UK Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK
Kirsty Harkness
Affiliation:
Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK
Aijaz Khan
Affiliation:
Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK
Markus Reuber
Affiliation:
Department of Neuroscience, University of Sheffield, UK Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK
Annalena Venneri*
Affiliation:
Department of Neuroscience, University of Sheffield, UK Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK
*
Prof. Annalena Venneri, Department of Neuroscience, Medical School, Beech Hill Road, Sheffield S10 2RX, UK. Tel: +44 114 2713430; Fax: +44 114 2222290 E-mail: [email protected]
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Abstract

Objectives

Patients with functional memory disorder (FMD) report significant memory failures in everyday life. Differentiating these patients from those with memory difficulties due to early stage neurodegenerative conditions is clinically challenging. The current study explored whether distinctive neuropsychological profiles could be established, suitable to differentiate patients with FMD from healthy individuals and those experiencing amnestic mild cognitive impairment (a-MCI).

Methods

Patients with a clinical diagnosis of FMD were compared with patients with a-MCI, and healthy matched controls on several tests assessing different cognitive functions. Patients with clinically established mood disorders were excluded. Patients with FMD and a-MCI were broadly comparable on the level of their subjective memory complaints as assessed by clinical interview.

Results

The neuropsychological profile of the FMD patients, although they expressed subjective memory and attention concerns during their clinical interview was distinct from patients with a-MCI on tests of memory [semantic fluency, age of acquisition (AoA) analysis of semantic fluency, verbal and non-verbal memory]. FMD patients did not differ significantly from healthy controls, but their scores on the letter fluency and digit cancellation tasks were not significantly different from those of the a-MCI patients indicating a possible sub-threshold deficit on these tasks.

Conclusion

Whilst subjective complaints are common within the FMD population, no objective impairment could be detected, even on a sensitive battery of tasks designed to detect subtle deficits caused by an early neurodegenerative brain disease. This study indicates that FMD patients can be successfully differentiated from patients with neurodegenerative memory decline by characterising their neuropsychological profile.

Keywords

Alzheimer’s diseaseamnesticmemoryneuropsychological testing
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 30 , Issue 2 , April 2018 , pp. 90 - 96
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Copyright
© Scandinavian College of Neuropsychopharmacology 2017 

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