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Decreased delta sleep ratio and elevated alpha power predict vulnerability to depression during interferon-alpha treatment

Published online by Cambridge University Press:  01 December 2014

Francis E. Lotrich  and
Anne Germain
Francis E. Lotrich*
Affiliation:
Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center; Pittsburgh, PA, USA
Anne Germain
Affiliation:
Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center; Pittsburgh, PA, USA
*
Dr. Francis E. Lotrich, Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, 3811 Ohara Street, Pittsburgh, PA 15213, USA. Tel: +1 412 246 6267; Fax: +1 412 246 6260; E-mail: [email protected]
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Abstract

Objective

Although poor sleep accompanies depression, it is unknown which specific sleep abnormalities precede depression. This is similarly the case for depression developing during interferon-α (IFN-α) therapy. Because vulnerability becomes evident in those who slept poorly before IFN-α, we prospectively determined which specific aspect of sleep could predict subsequent depression.

Methods

Two nights of polysomnography with quantitative electroencephalogram (EEG) were obtained in 24 adult, euthymic subjects – all subsequently treated with IFN-α for hepatitis C. Every 2 weeks, a Beck Depression Inventory-II (BDI-II) score was obtained, and the maximal increase in BDI-II from pre-treatment baseline – excluding the sleep question – was determined.

Results

The delta sleep ratio (DSR; an index of early-night restorative delta power) was inversely associated with BDI-II increases (p<0.01), as was elevated alpha power (8–12 Hz; p<0.001). Both delta (0.5–4 Hz) and alpha power exhibited high between-night correlations (r=0.83 and 0.92, respectively). In mixed-effect repeated-measure analyses, there was an interaction between alpha power and DSR (p<0.001) – subjects with low alpha power and elevated DSR were resilient to developing depression. Most other sleep parameters – including total sleep time and percentage of time in slow wave sleep – were not associated with subsequent changes in depression.

Conclusions

Both high DSR and low alpha power may be specific indices of resilience. As most other aspects of sleep were not associated with resilience or vulnerability, sleep interventions to prevent depression may need to specifically target these specific sleep parameters.

Keywords

depressionEEGHCVhepatitispsychoneuroimmunologysleep
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 1 , February 2015 , pp. 14 - 24
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Copyright
© Scandinavian College of Neuropsychopharmacology 2014 

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References

1.Patten, SB. Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2. J Affective Disord 2001;63:35–41.Google Scholar
2.Eaton, WW, Kramer, M, Anthony, JC, Dryman, A, Shapiro, S, Locke, BZ. The incidence of specific DIS/DSM-III mental disorders: data from the NIMH Epidemiologic Catchment Area Program. Acta Psychiatr Scand 1989;79:163–178.Google Scholar
3.Patten, SB, Lee, RC. Refining estimates of major depression incidence and episode duration in Canada using a Monte Carlo Markov model. Med Decis Making 2004;24:351–358.Google Scholar
4.Kruijt, A-W, Antypa, N, Booij, Let al. Cognitive reactivity, implicit associations, and the incidence of depression: a two-year prospective study. PLoS One 2013;8:e70245.CrossRefGoogle ScholarPubMed
5.Boyes, AW, Girgis, A, D'Este, CA, Zucca, AC, Lecathelinais, C, Carey, ML. Prevalence and predictors of the short-term trajectory of anxiety and depression in the first year after a cancer diagnosis: a population-based longitudinal study. J Clin Oncol 2013;31:2724–2729.CrossRefGoogle ScholarPubMed
6.Udina, M, Castellvi, P, Moreno-Espana, Jet al. Interferon-induced depression in chronic hepatitis C: a systematic review and meta-analysis. J Clin Psychiatry 2012;73:1128–1138.Google Scholar
7.Breslau, N, Roth, T, Rosenthal, L, Andreski, P. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry 1996;39:411–418.CrossRefGoogle ScholarPubMed
8.Gregory, AM, Rijsdijk, FV, Lau, JYet al. The direction of longitudinal associations between sleep problems and depression symptoms: a study of twins aged 8 and 10 years. Sleep 2009;32:189–199.Google Scholar
9.Buysse, DJ, Angst, J, Gamma, A, Ajdacic, V, Eich, D, Rossler, W. Prevalence, course, and comorbidity of insomnia and depression in young adults. Sleep 2008;31:473–480.CrossRefGoogle ScholarPubMed
10.Roane, BM, Taylor, DJ. Adolescent insomnia as a risk factor for early adult depression and substance abuse. Sleep 2008;31:1351–1356.Google ScholarPubMed
11.Emslie, GJ, Armitage, R, Weinberg, WA, Rush, AJ, Mayes, TL, Hoffmann, RF. Sleep polysomnography as a predictor of recurrence in children and adolescents with major depressive disorder. Int J Neuropsychopharmacol 2001;4:159–168.Google Scholar
12.Buysse, DJ, Hall, M, Tu, XMet al. Latent structure of EEG sleep variables in depressed and control subjects: descriptions and clinical correlates. Psychiatry Res 1998;79:105–122.CrossRefGoogle ScholarPubMed
13.Armitage, R, Hoffmann, R, Trivedi, M, Rush, AJ. Slow-wave activity in NREM sleep: sex and age effects in depressed outpatients and healthy controls. Psychiatry Res 2000;95:201–213.CrossRefGoogle ScholarPubMed
14.Steiger, A, Kimura, M. Wake and sleep EEG provide biomarkers in depression. J Psychiatr Res 2010;44:242–252.Google Scholar
15.Kupfer, DJ, Frank, E, Ehlers, CL. EEG sleep in young depressives: first and second night effects. Biol Psychiatry 1989;25:87–97.Google Scholar
16.Kupfer, DJ, Frank, E, McEachran, AB, Grochocinski, VJ. Delta sleep ratio. A biological correlate of early recurrence in unipolar affective disorder. Arch Gen Psychiatry 1990;47:1100–1105.Google Scholar
17.Wichniak, A, Wierzbicka, A, Jernajczyk, W. Sleep and antidepressant treatment. Curr Pharm Des 2012;18:5808–5817.Google Scholar
18.Felger, JC, Lotrich, FE. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 2013;246:199–229.Google Scholar
19.Franzen, PL, Buysse, DJ, Rabinovitz, M, Pollock, BG, Lotrich, FE. Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment. J Psychiatr Res 2009;177:240–245.Google Scholar
20.Prather, A, Rabinvitz, M, Pollock, B, Lotrich, F. Cytokine-induced depression during IFN-a treatment: the role of IL-6 and sleep quality. Brain Behav Immunol 2009;23:1109–1116.CrossRefGoogle Scholar
21.Campbell, IG, Darchia, N, Higgins, LMet al. Adolescent changes in homeostatic regulation of EEG activity in the delta and theta frequency bands during NREM sleep. Sleep 2011;34:83–91.Google Scholar
22.Csercsa, R, Dombovari, B, Fabo, Det al. Laminar analysis of slow wave activity in humans. Brain 2010;133:2814–2829.Google Scholar
23.Dworak, M, McCarley, RW, Kim, T, Kalinchuk, AV, Basheer, R. Sleep and brain energy levels: ATP changes during sleep. J Neurosci Res 2010;30:9007–9016.Google Scholar
24.Murphy, M, Riedner, BA, Huber, R, Massimini, M, Ferrarelli, F, Tononi, G. Source modeling sleep slow waves. PNAS USA 2009;106:1608–1613.Google Scholar
25.Dang-Vu, TT, Desseilles, M, Laureys, Set al. Cerebral correlates of delta waves during non-REM sleep revisited. Neuroimage 2005;28:14–21.Google Scholar
26.Nofzinger, EA. Neuroimaging of sleep and sleep disorders. Curr Neurol Neurosci Rep 2006;6:149–155.Google Scholar
27.Hall, M, Thayer, JF, Germain, Aet al. Psychological stress is associated with heightened physiological arousal during NREM sleep in primary insomnia. Behav Sleep Med 2007;5:178–193.Google Scholar
28.Germain, A, Nofzinger, EA, Kupfer, DJ, Buysse, DJ. Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation. Am J Psychiatry 2004;161:1856–1863.Google Scholar
29.Kupfer, DJ, Reynolds, CF, Ulrich, RF, Grochocinski, VJ. Comparison of automated REM and slow-wave sleep analyses in young and middle-aged depressed subjects. Biol Psychiatry 1986;21:189–200.Google Scholar
30.Spanier, C, Frank, E, McEachran, AB, Grochocinski, VJ, Kupfer, DJ. The prophylaxis of depressive episodes in recurrent depression following discontinuation of drug therapy: integrating psychological and biological factors. Psychol Med 1996;26:461–475.Google Scholar
31.Buysse, DJ, Frank, E, Lowe, KK, Cherry, CR, Kupfer, DJ. Electroencephalographic sleep correlates of episode and vulnerability to recurrence in depression. Biol Psychiatry 1997;41:406–418.Google Scholar
32.Reynolds, CFr, Buysse, DJ, Brunner, DPet al. Maintenance nortriptyline effects on electroencephalographic sleep in elderly patients with recurrent major depression: double-blind, placebo- and plasma-level-controlled evaluation. Biol Psychiatry 1997;42:560–567.CrossRefGoogle ScholarPubMed
33.Lauer, CJ, Schreiber, W, Holsboer, F, Krieg, JC. In quest of identifying vulnerability markers for psychiatric disorders by all-night polysomnography. Arch Gen Psychiatry 1995;52:145–153.Google Scholar
34.Fenzl, T, Touma, C, Romanowski, CPet al. Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression. BMC Neurosci 2011;12:29.Google Scholar
35.Nitschke, JB, Heller, W, Etienne, MA, Miller, GA. Prefrontal cortex activity differentials processes affecting memory in depression. Biol Psychiatry 2004;67:125–143.Google Scholar
36.von Stein, A, Sarnthein, J. Different frequencies for different scales of cortical integration: from local gamma to long range alpha/theta synchronization. Int J Psychophysiol 2000;38:301–313.Google Scholar
37.Bjorvatn, B, Fagerland, S, Ursin, R. EEG power densities (0.5–20 Hz) in different sleep-wake stages in rats. Physiol Behav 1998;63:413–417.CrossRefGoogle Scholar
38.Nofzinger, EA, Price, JC, Meltzer, CCet al. Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep. Psychiatry Res 2000;98:71–91.Google Scholar
39.Krystal, AD, Edinger, JD. Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep 2010;33:669–677.Google Scholar
40.Bastien, CH, LeBlanc, M, Carrier, J, Morin, CM. Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines. Sleep 2003;26:313–317.Google Scholar
41.Feinberg, I, Maloney, T, Campbell, IG. Effects of hypnotics on the sleep EEG of healthy young adults: new data and psychopharmacologic implications. J Psychiatr Res 2000;34:423–438.Google Scholar
42.Dumont, GJ, de Visser, SJ, Cohen, AF, van Gerven, JM. Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects. Br J Clin Pharmacol 2005;59:495–510.Google Scholar
43.Silvestri, R, Pace-Schott, EF, Gersh, T, Stickgold, R, Salzman, C, Hobson, JA. Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal. J Clin Psychiatry 2001;62:642–652.Google Scholar
44.Britton, WB, Haynes, PL, Fridel, KW, Bootzin, RR. Polysomnographic and subjective profiles of sleep continuity before and after mindfulness-based cognitive therapy in partially remitted depression. Psychosom Med 2010;72:539–548.Google Scholar
45.Lundahl, J, Deacon, S, Maurice, D, Staner, L. EEG spectral power density profiles during NREM sleep for gaboxadol and zolpidem in patients with primary insomnia. J Psychopharmacol 2012;26:1081–1087.Google Scholar
46.Quera-Salva, MA, Hajak, G, Philip, Pet al. Comparison of agomelatine and escitalopram on nighttime sleep and daytime condition and efficacy in major depressive disorder patients. Int Clin Psychopharmacol 2011;26:252–262.Google Scholar
47.First, MB, Spitzer, RL, Williams, JBWet al. Structured clinical interview for DSM-IV (SCID-1) (users guide and interview) research version. New York: Biometrics Research Department, New York Psychiatric Institute, 1995.Google Scholar
48.Beck, A, Steer, R, Garbin, M. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev 1988;8:77–100.Google Scholar
49.Buysse, DJ, Reynolds, CF, Monk, TH, Berman, SR, Kupfer, DJ. Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatr Res 1989;28:193–213.Google Scholar
50.Hayashino, Y, Yamazaki, S, Takegami, M, Nakayama, T, Sokejima, S, Fukuhara, S. Association between number of comorbid conditions, depression, and sleep quality using the Pittsburgh Sleep Quality Index: results from a population-based survey. Sleep Med 2010;11:366–371.Google Scholar
51.Owen, DC, Parker, KP, McGuire, DB. Comparison of subjective sleep quality in patients with cancer and healthy subjects. Oncol Nurs Forum 1999;26:1649–1651.Google Scholar
52.Carpenter, J, Andrykowski, MA. Psychometric evaluation of the Pittsburgh Sleep Quality Index. J Psychosom Res 1998;45:5–13.Google Scholar
53.Monk, TH, Reynolds, CF, Kupfer, DJet al. The Pittsburgh Sleep Diary. J Sleep Res 1994;3:111–120.Google Scholar
54.Doman, J, Detka, C, Hoffman, Tet al. Automating the sleep laboratory: implementation and validation of digital recording and analysis. Int J Biomed Comput 1995;38:277–290.Google Scholar
55.Brunner, DP, Vasko, RC, Detka, CS, Monahan, JP, Reynolds, CF, Kupfer, DJ. Muscle artifacts in the sleep EEG: automated detection and effect on all-night EEG power spectra. J Sleep Res 1996;5:155–164.Google Scholar
56.Lange, H. EEG spectral analysis in vital depression: ultradian cycles. Biol Psychiatry 1982;17:3–21.Google Scholar
57.McKinney, SM, Dang-Vu, TT, Buxton, OM, Solet, JM, Ellenbogen, JM. Covert waking brain activity reveals instantaneous sleep depth. PLoS One 2011;6:e17351.Google Scholar
58.Dahl, RE, Williamson, DE, Bertocci, MA, Stolz, MV, Ryan, ND, Ehlers, CL. Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study. Alcohol Alcohol 2003;30:193–200.Google Scholar
59.Budhiraja, R, Quan, SF, Punjabi, NM, Drake, CL, Dickman, R, Fass, R. Power spectral analysis of the sleep electroencephalogram in heartburn patients with or without gastroesophageal reflux disease: a feasibility study. J Clin Gastroenterol 2010;44:91–96.Google Scholar
60.Harman, K, Pivik, RT, D'Eon, JL, Wilson, KG, Swenson, JR, Matsunaga, L. Sleep in depressed and nondepressed participants with chronic low back pain: electroencephalographic and behaviour findings. Sleep 2002;25:775–783.Google Scholar
61.Steriade, M, McCarley, R. Brainstem control of wakefulness and sleep. New York: Plenum, 1990.Google Scholar
62.Staner, L, Cornette, F, Maurice, Det al. Sleep microstructure around sleep onset differentiates major depressive insomnia from primary insomnia. J Sleep Res 2003;12:319–330.Google Scholar
63.Merica, H, Blois, R, Gaillard, JM. Spectral characteristics of sleep EEG in chronic insomnia. Eur J Neurosci 1998;10:1826–1834.Google Scholar
64.Luthringer, R, Minot, R, Toussaint, M, Calvi-Gries, F, Schaltenbrand, N, Macher, JP. All-night EEG spectral analysis as a tool for the prediction of clinical response to antidepressant treatment. Biol Psychiatry 1995;38:98–104.Google Scholar
65.Linkowski, P. EEG sleep patterns in twins. J Sleep Res 1999;8:11–13.Google Scholar
66.Ambrosius, U, Lietzenmaier, S, Wehrle, Ret al. Heritability of sleep electroencephalogram. Biol Psychiatry 2008;64:344–348.Google Scholar
67.Buckelmuller, J, Landolt, HP, Stassen, HH, Achermann, P. Trait-like individual differences in the human sleep electroencephalogram. Neuroscience 2006;138:351–356.Google Scholar
68.Tucker, AM, Dinges, DF, Van Dongen, HPA. Trait interindividual differences in the sleep physiology of healthy young adults. J Sleep Res 2007;16:170–180.Google Scholar
69.Datta, S, Maclean, RR. Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence. Neurosci Biobehav Rev 2007;31:775–824.Google Scholar
70.Silva, RH, Abilio, VC, Takatsu, ALet al. Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice. Neuropharmacol 2004;46:895–903.Google Scholar
71.Hairston, IS, Little, MTM, Scanlon, MDet al. Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning. J Neurophysiol 2005;94:4224–4233.Google Scholar
72.Roman, V, Van der Borght, K, Leemburg, SAet al. Sleep restriction by forced activity reduces hippocampal cell proliferation. Brain Res 2005;1065:53–59.CrossRefGoogle ScholarPubMed
73.Corner, MA, Baker, RE, van Pelt, J. Physiological consequences of selective suppression of synaptic transmission in developing cerebral cortical networks in vitro: differential effects on intrinsically generated bioelectric discharges in a living ‘model’ system for slow-wave sleep activity. Neurosci Biobehav Rev 2008;32:1569–1600.Google Scholar
74.Krueger, JM, Obal, F. Sleep function. Front Biosci 2003;8:511–519.Google Scholar
75.Guzman-Marin, R, Ying, Z, Suntsova, Net al. Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats. J Physiol 2006;575:807–819.Google Scholar
76.Romcy-Pereira, RN, Leite, JP, Garcia-Cairasco, N. Synaptic plasticity along the sleep-wake cycle: implications for epilepsy. Epilepsy Behav 2009;14:47–53.Google Scholar
77.Leproult, R, Copinschi, G, Buxton, Oet al. Sleep loss results in an elevation of cortisol levels the next evening. Sleep 1997;20:865–870.Google Scholar
78.Spath-Schwalbe, E, Gofferje, M, Kern, W, Born, J, Fehm, HL. Sleep disruption alters nocturnal ACTH and cortisol secretory patterns. Biol Psychiatry 1991;29:575–584.Google Scholar
79.Hofle, N, Paus, T, Reutens, D, Fiset, P, Gotman, J, Evans, A. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J Neurosci 1997;17:4800–4808.Google Scholar
80.Lotrich, FE, Albusaysi, S, Ferrell, RE. Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-alpha treatment. Neuropsychopharmacol 2013;38:989–995.Google Scholar
81.Kaneko, N, Kudo, K, Mabuchi, Tet al. Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus. Neuropsychopharmacol 2006;31:2619–2626.Google Scholar
82.Ben Menachem-Zidon, O, Goshen, I, Kreisel, Tet al. Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacol 2008;33:2251–2262.Google Scholar
83.Barrientos, RM, Sprunger, DB, Campeau, Set al. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience 2003;121:847–853.Google Scholar
84.Koo, JW, Duman, RS. IL-1beta is an essential mediator of the antineurogenic and anhedondic effects of stress. PNAS USA 2008;105:751–756.Google Scholar
85.Peng, CH, Chiou, SH, Chen, SJ, Chou, YC, Ky, HH, Cheng, CK. Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. Eur Neuropsychopharmacol 2008;18:128–140.Google Scholar
86.Raison, CL, Borisov, AS, Woolwine, BJ, Massung, B, Vogt, G, Miller, AH. Interferon-alpha effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol Psychiatry 2010;15:535–547.Google Scholar
87.Raison, CL, Borisov, AS, Majer, M, Drake, D, Pagnoni, G, Miller, AH. Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biol Psychiatry 2009;65:296–303.Google Scholar
88.Felger, JC, Alagbe, O, Hu, Fet al. Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression. Biol Psychiatry 2007;62:1324–1333.Google Scholar
89.Haroon, E, Woolwine, B, Chen, Xet al. IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacol 2014;39:1777–1785.Google Scholar
90.Raison, CL, Rye, DB, Woolwine, BJet al. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol Psychiatry 2010;68:942–949.Google Scholar
91.Antonijevic, IA, Steiger, A. Depression-like changes of the sleep-EEG during high dose corticosteroid treatment in patients with multiple sclerosis. Psychoneuroendocrinol 2003;28:780–795.Google Scholar
92.Thase, ME, Fasiczka, AL, Berman, SR, Simons, AD, Reynolds, CF. Electroencephalographic sleep profiles before and after cognitive behavior therapy of depression. Arch Gen Psychiatry 1998;55:138–144.Google Scholar
93.Nissen, C, Feige, B, Konig, A, Voderholzer, U, Berger, M, Riemann, D. Delta sleep ratio as a predictor of sleep deprivation response in major depression. J Psychiatr Res 2001;35:155–163.Google Scholar
94.Kupfer, DJ, Frank, E, McEachran, AB, Grochocinski, VJ, Ehlers, CL. EEG sleep correlates of recurrence of depression on active medication. Depression 1993;1:300–308.Google Scholar
95.Cervena, K, Dauvilliers, Y, Espa, Fet al. Effect of cognitive behavioural therapy for insomnia on sleep architecture and sleep EEG power spectra in psychophysiological insomnia. J Sleep Res 2004;13:385–393.Google Scholar
96.Sonntag, A, Rothe, B, Guldner, J, Yassouridis, A, Holsboer, F, Steiger, A. Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression. Depression 1996;4:1–13.Google Scholar
97.Chalon, S, Pereira, A, Lainey, Eet al. Comparative effects of duloxetine and desipramine on sleep EEG in healthy subjects. Psychopharmacol (Berl) 2005;177:357–365.Google Scholar
98.Schittecatte, M, Dumont, F, Machowski, R, Cornil, C, Lavergne, F, Wilmotte, J. Effects of mirtazapine on sleep polygraphic variables in major depression. Neuropsychobiol 2002;46:197–201.Google Scholar
99.Argyropoulos, SV, Wilson, SJ. Sleep disturbances in depression and the effects of antidepressants. Int Rev Psychiatry 2005;17:237–245.Google Scholar
100.Jindal, RD, Friedman, ES, Berman, SR, Fasiczka, AL, Howland, RH, Thase, ME. Effects of sertraline on sleep architecture in patients with depression. J Clin Psychopharmacol 2003;23:540–548.CrossRefGoogle ScholarPubMed
101.Ehlers, CL, Havstad, JW, Kupfer, DJ. Estimation of the time course of slow-wave sleep over the night in depressed patients: effects of clomipramine and clinical response. Biol Psychiatry 1996;39:171–181.Google Scholar
102.Feige, B, Voderholzer, U, Riemann, D, Dittmann, R, Hohagen, F, Berger, M. Fluoxetine and sleep EEG: effects of a single dose, subchronic treatment, and discontinuation in healthy subjects. Neuropsychopharmacol 2002;26:246–258.Google Scholar
103.Pasternak, RE, Reynolds, CF 3rd, Houck, PRet al. Sleep in bereavement-related depression during and after pharmacotherapy with nortriptyline. J Geriatr Psychiatry Neurol 1994;7:69–73.Google Scholar
104.Argyropoulos, SV, Hicks, JA, Nash, JRet al. Redistribution of slow wave activity of sleep during pharmacological treatment of depression with paroxetine but not with nefazodone. J Sleep Res 2009;18:342–343.Google Scholar
105.Musselman, DL, Lawson, DH, Gumnick, JFet al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. NEJM 2001;344:961–966.Google Scholar
106.Nowell, PD, Reynolds, CFr, Buysse, DJ, Dew, MA, Kupfer, DJ. Paroxetine in the treatment of primary insomnia: preliminary clinical and electroencephalogram sleep data. J Clin Psychiatry 1999;60:89–95.CrossRefGoogle ScholarPubMed
107.Salva, M-AQ, Vanier, B, Laredo, Jet al. Major depressive disorder, sleep EEG and agomelatine: an open-label study. Int J Neuropsychopharmacol 2007;10:691–696.Google Scholar
108.Quera-Salva, MA, Lemoine, P, Guilleminault, C. Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients. Hum Psychopharmacol 2010;25:222–229.Google Scholar
109.Kluge, M, Gazea, M, Schussler, Pet al. Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women. Psychoneuroendocrinol 2010;35:297–304.Google Scholar
110.Lotrich, FE. Inflammatory cytokine-associated depression. Brain Res 2014; epub 10.1016/j.brainres.2014.06.032.Google Scholar
111.Ford, DE, Kamerow, DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA 1989;262:1479–1484.Google Scholar