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De ontwikkelingsneurologische theorie van schizofrenie: bewijsmateriaal betreffende structuur en neuropsychologic

Published online by Cambridge University Press:  18 September 2015

S.E. Chua  and
R.M. Murray
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Summary

Severe schizophrenics as a group show subtle abnormalities of cerebral structure. Cerebral ventricular enlargement is the best replicated finding, and this tends to be associated with impairment of neuropsychological performance. The idea that these abnormalities have a neurodevelopmental origin gains indirect support from the, admittedly less consistent, evidence of abnormalities of cerebral asymmetry and of neuronal migration in adult schizophrenics, as well as from the behavioural, psychomotor, and cognitive impairments reported in preschizophrenic children. However, the relationship between childhood and adult neuropsychological and brain structural findings has not been proven, and we do not know whether only some schizophrenics have a developmental origin, or whether patients differ only in the degree of developmental impairment that they show.

Keywords

SchizophrenianeurodevelopmentalneuropsychologystructurefunctionalimagingSchizofrenieontwikkelingsneurologischneuropsychologicstructuurfunctionedbeeldvorming
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 8 , Issue 2 , June 1996 , pp. 25 - 34
Copyright
Copyright © Cambridge University Press 1996

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