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Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes

Published online by Cambridge University Press:  13 August 2021

Rosaria Di Lorenzo Open the ORCID record for Rosaria Di Lorenzo [Opens in a new window] ,
Jessica Balducci Open the ORCID record for Jessica Balducci [Opens in a new window] ,
Chiara Poppi ,
Elisa Arcolin ,
Anna Cutino ,
Paola Ferri Open the ORCID record for Paola Ferri [Opens in a new window] ,
Roberto D’Amico Open the ORCID record for Roberto D’Amico [Opens in a new window]  and
Tommaso Filippini Open the ORCID record for Tommaso Filippini [Opens in a new window]
Rosaria Di Lorenzo*
Affiliation:
Psychiatric Intensive Treatment Facility, Mental Health and Drug Abuse Department of AUSL-Modena, Modena, Italy
Jessica Balducci
Affiliation:
School of Specialization in Psychiatry, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Chiara Poppi
Affiliation:
School of Nursing, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Elisa Arcolin
Affiliation:
School of Specialization in Psychiatry, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Anna Cutino
Affiliation:
School of Specialization in Psychiatry, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Paola Ferri
Affiliation:
School of Nursing, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Roberto D’Amico
Affiliation:
Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy Unit of Statistical and Methodological Support, AOU of Modena, Modena
Tommaso Filippini
Affiliation:
Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
*
Author for correspondence: Rosaria Di Lorenzo, Email: [email protected]
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Abstract

The objective is to highlight the clinical and social outcomes among adults who suffered from Attention-Deficit Hyperactivity Disorder (ADHD) in their childhood/adolescence. PubMed, PsycINFO, and Scopus databases were searched for prospective studies published during the last 5 years addressing patients with ADHD in childhood/adolescence followed-up to adulthood. We also included studies published before 2015 reported in other reviews with similar outcomes. Thousand four-hundred and eighty-five studies were identified, but only 39 were included for qualitative analysis and 27 for quantitative analysis. Overall, we found that ADHD persisted into adulthood with a mean rate of 43% and was mainly associated with both substance/alcohol use disorders and antisocial behavior and, less frequently, with anxiety and depressive disorders. The prevalence of persistent ADHD in adulthood reported by studies published after 2011 (55%) was higher than that reported by studies published previously from 1985 to 2011 (34%), suggesting a greater focus on ADHD in recent years. Our results highlight that ADHD can be considered not only a neurodevelopmental disorder, but also a persistent and complex condition, with detrimental consequences for quality of life in adulthood.

Keywords

alcohol-related disordersantisocial personality disorderattention deficit hyperactivity disorderproblem behavior
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 33 , Issue 6 , December 2021 , pp. 283 - 298
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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References

Agnew-Blais, JC, Polanczyk, GV, Danese, A, Wertz, J, Moffitt, TE and Arseneault, L (2016) Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry 73, 713–720. doi: 10.1001/jamapsychiatry.2016.0465 CrossRefGoogle ScholarPubMed
American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders (3rd ed.). Washington, DC.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev). Washington, DC.Google Scholar
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC.Google Scholar
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA. Google Scholar
American Psychological Association (2012) New guidelines for ADHD among children. Monitor in Psychology 43, 65. https://www.apa.org/monitor/2012/03/adhd-guidelines Google Scholar
Babinski, LM, Hartsough, CS and Lambert, NM (1999) Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity. Journal of Child Psychology and Psychiatry 40, 347–355. doi: 10.1111/1469-7610.00452 CrossRefGoogle ScholarPubMed
Balazs, J and Kereszteny, A (2017) Attention-deficit/hyperactivity disorder and suicide: a systematic review. World Journal of Psychiatry 7, 44–59. doi: 10.5498/wjp.v7.i1.44 CrossRefGoogle ScholarPubMed
Barbaresi, WJ, Colligan, RC, Weaver, AL, Voigt, RG, Killian, JM and Katusic, SK (2013) Mortality, ADHD, and psychosocial adversity in adults with childhood ADHD: a prospective study. Pediatrics 131, 637–644. doi: 10.1542/peds.2012-2354 CrossRefGoogle ScholarPubMed
Barkley, RA, Fischer, M, Smallish, L and Fletcher, K (2002) The persistence of attention-deficit/hyperactivity disorder in to young adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology 111, 279–289. doi: 10.1037/0021-843X.111.2.279 CrossRefGoogle ScholarPubMed
Barkley, RA, Fischer, M, Smallish, L and Fletcher, K (2003) Does the treatment of attention-deficit/hyperactivity disorder with stimulants contribute to drug use/abuse? A 13-year prospective study. Pediatrics 111, 97–109. doi: 10.1542/peds.111.1.97 CrossRefGoogle ScholarPubMed
Barkley, RA, Fischer, M, Smallish, L and Fletcher, K (2004) Young adult follow-up of hyperactive children: antisocial activities and drug use. Journal of Child Psychology and Psychiatry 45, 195–211. doi: 10.1111/j.1469-7610.2004.00214.x CrossRefGoogle ScholarPubMed
Barry, RJ, Clarke, AR and Johnstone, SJ (2003) A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clinical Neurophysiology 114, 171–183. doi: 10.1016/s1388-2457(02)00362-0 CrossRefGoogle ScholarPubMed
Biederman, J, Monuteaux, MC, Spencer, T, Wilens, TE and Faraone, SV (2009) Do stimulants protect against psychiatric disorders in youth with ADHD? A 10-year follow-up study. Pediatrics 124, 71–78. doi: 10.1542/peds.2008-3347 CrossRefGoogle ScholarPubMed
Biederman, J, Petty, CR, Clarke, A, Lomedico, A and Faraone, SV (2011) Predictors of persistent ADHD: an 11-year follow-up study. Journal of Psychiatric Research 45, 150–155. doi: 10.1016/j.jpsychires.2010.06.009 CrossRefGoogle Scholar
Biederman, J, Petty, CR, Dolan, C, Hughes, S, Mick, E, Monuteaux, MC and Faraone, SV (2008) The long-term longitudinal course of oppositional defiant disorder and conduct disorder in ADHD boys: findings from a controlled 10-year prospective longitudinal follow-up study. Psychological Medicine 38, 1027–1036. doi: 10.1017/S0033291707002668 CrossRefGoogle ScholarPubMed
Biederman, J, Petty, CR, O’Connor, KB, Hyder, LL and Faraone, SV (2012b) Predictors of persistence in girls with attention deficit hyperactivity disorder: results from an 11-year controlled follow-up study. Acta Psychiatrica Scandinavica 125, 147–156. doi: 10.1111/j.1600-0447.2011.01797.x CrossRefGoogle ScholarPubMed
Biederman, J, Petty, CR, Woodworth, KY, Lomedico, A, Hyder, LL and Faraone, SV (2012a) Adult outcome of attention-deficit/hyperactivity disorder: a controlled 16-year follow-up study. Journal of Clinical Psychiatry 73, 941–950. doi: 10.4088/JCP.11m07529 CrossRefGoogle ScholarPubMed
Boland, H, DiSalvo, M, Fried, R, Woodworth, KY, Wilens, T, Faraone, SV and Biederman, J (2020) A literature review and meta-analysis on the effects of ADHD medications on functional outcomes. Journal of Psychiatric Research 123, 21–30. doi: 10.1016/j.jpsychires.2020.01.006 CrossRefGoogle ScholarPubMed
Bond, DJ, Hadjipavlou, G, Lam, RW, McIntyre, RS, Beaulieu, S, Schaffer, A and Weiss, M (2012) The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid attention-deficit/hyperactivity disorder. Annals of Clinical Psychiatry 24, 23–37.Google ScholarPubMed
Breyer, JL, Botzet, AM, Winters, KC, Stinchfield, RD, August, G and Realmuto, G (2009) Young adult gambling behaviors and their relationship with the persistence of ADHD. Journal of Gambling Studies 25, 227–238. doi: 10.1007/s10899-009-9126-z CrossRefGoogle ScholarPubMed
Breyer, JL, Lee, S, Winters, KC, August, GJ and Realmuto, GM (2014) A longitudinal study of childhood ADHD and substance dependence disorders in early adulthood. Psychology of Addictive Behaviors 28, 238–246. doi: 10.1037/a0035664 CrossRefGoogle ScholarPubMed
Brook, JS, Brook, DW, Zhang, C, Seltzer, N and Finch, SJ (2013) Adolescent ADHD and adult physical and mental health, work performance, and financial stress. Pediatrics 131, 5–13. doi: 10.1542/peds.2012-1725 CrossRefGoogle ScholarPubMed
Bush, G, Valera, EM and Seidman, LJ (2005) Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biological Psychiatry 57,1273–1284. doi: 10.1016/j.biopsych.2005.01.034 CrossRefGoogle ScholarPubMed
Castelli, M, Federici, M, Rossi, S, De Chiara, V, Napolitano, F, Studer, V, Motta, C, Sacchetti, L, Romano, R, Musella, A, Bernardi, G, Siracusano, A, Gu, HH, Mercuri, NB, Usiello, A and Centonze, D (2011) Loss of striatal cannabinoid cb1 receptor function in attention-deficit/hyperactivity disorder mice with point-mutation of the dopamine transporter. European Journal of Neuroscience 34, 1369–1377. doi: 10.1111/j.1460-9568.2011.07876.x CrossRefGoogle ScholarPubMed
Caye, A, Rocha, TBM, Anselmi, L, Murray, J, Menezes, AMB, Barros, FC, Gonçalves, H, Wehrmeister, F, Jensen, CM, Steinhausen, HC, Swanson, JM, Kieling, C and Rohde, LA (2016) Attention-Deficit/Hyperactivity Disorder trajectories from childhood to young adulthood: evidence from a birth cohort supporting a late-onset syndrome. JAMA Psychiatry 73, 705–712. doi: 10.1001/jamapsychiatry.2016.0383 CrossRefGoogle ScholarPubMed
Chronis-Tuscano, A, Molina, BSG, Pelham, WE, Applegate, B, Dahlke, A, Overmyer, M and Lahey, BB (2010) Very early predictors of adolescent depression and suicide attempts in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 67, 1044–1051. doi: 10.1001/archgenpsychiatry.2010.127.CrossRefGoogle ScholarPubMed
Dalsgaard, S, Ostergaard, SD, Leckman, JF, Mortensen, PB and Pedersen, MG (2015) Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet 385, 2190–2196. doi: 10.1016/S0140-6736(14)61684-6 CrossRefGoogle ScholarPubMed
De Sanctis, VA, Newcorn, JH and Halperin, JM (2014) A prospective look at substance use and criminal behavior in urban ADHD youth: what is the role of maltreatment history on outcome? Attention Deficit and Hyperactivity Disorders 6, 79–86. doi: 10.1007/s12402-013-0124-8 Google Scholar
Di Nicola, M, Sala, L, Romo, L, Catalano, V, Even, C, Dubertret, C, Martinotti, G, Camardese, G, Mazza, M, Tedeschi, D, Callea, A, De Risio, L, Guelfi, JD, Rouillon, F, Janiri, L and Gorwood, P (2014) Adult attention-deficit/hyperactivity disorder in major depressed and bipolar subjects: role of personality traits and clinical implications. European Archives of Psychiatry and Clinical Neuroscience 264, 391–400. doi: 10.1007/s00406-013-0456-6 CrossRefGoogle ScholarPubMed
Dobrosavljevic, M, Solares, C, Cortese, S, Andershed, H and Larsson, H (2020) Prevalence of attention-deficit/hyperactivity disorder in older adults: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 118, 282–289. doi: 10.1016/j.neubiorev.2020.07.042.CrossRefGoogle ScholarPubMed
Döpfner, M, Ise, E, Breuer, D, Rademacher, C, Metternich-Kaizman, TW and Schürmann, S (2016) Long-term course after adaptive multimodal treatment for children with ADHD: an 8-year follow-up. Journal of Attention Disorders 24, 145–162. doi: 10.1177/1087054716659138.CrossRefGoogle Scholar
Erskine, HE, Norman, RE, Ferrari, AJ, Chan, GCK, Copeland, WE, Whiteford, HA and Scott, JG (2016) Long-term outcomes of attention-deficit/hyperactivity disorder and conduct disorder: a systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 55, 841–850. doi: 10.1016/j.jaac.2016.06.016 CrossRefGoogle ScholarPubMed
Estevez, N, Dey, M, Eich-Hochli, D, Foster, S, Gmel, G and Mohler-Kuo, M (2016) Adult attention-deficit/hyperactivity disorder and its association with substance use and substance use disorders in young men. Epidemiology and Psychiatric Sciences 25, 255–266. doi: 10.1017/S2045796015000360 CrossRefGoogle ScholarPubMed
Faraone, SV, Biederman, J, Mick, E (2006) The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychological Medicine 36, 159–165. doi: 10.1017/S003329170500471X CrossRefGoogle ScholarPubMed
Faraone, SV, Perlis, RH, Doyle, AE, Smoller, JW, Goralnick, J, Holmgren, MA and Sklar, P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry 57, 1313–1323. doi: 10.1016/j.biopsych.2004.11.024 CrossRefGoogle ScholarPubMed
Fayyad, J, Sampson, NA, Hwang, I, Adamowski, T, Aguilar-Gaxiola, S, Al-Hamzawi, A, Andrade, LHSG, Borges, G, de Girolamo, G, Florescu, S, Gureje, O, Haro, JM, Hu, C, Karam, EG, Lee, S, Navarro-Mateu, F, O’Neill, S, Pennell, BE, Piazza, M, Posada-Villa, J, Have, MT, Torres, Y, Xavier, M, Zaslavsky, AM, Kessler, RC and WHO World Mental Health Survey Collaborators (2017) The descriptive epidemiology of DSM-IV adult ADHD in the World Health Organization world mental health surveys. Attention Deficit and Hyperactivity Disorders 9, 46–65. doi: 10.1007/s12402-016-0208-3 CrossRefGoogle ScholarPubMed
Fergusson, DM and Boden, JM (2008) Cannabis use and adult ADHD symptoms. Drug and Alcohol Dependence 95, 90–96. doi: 10.1016/j.drugalcdep.2007.12.012 CrossRefGoogle ScholarPubMed
Fergusson, DM, Horwood, LJ and Ridder, EM (2007) Conduct and attentional problems in childhood and adolescence and later substance use, abuse and dependence: results of a 25-year longitudinal study. Drug and Alcohol Dependence 88(SUPPL.1), S14–S26. doi: 10.1016/j.drugalcdep.2006.12.011 CrossRefGoogle ScholarPubMed
Fischer, M, Barkley, RA, Smallish, L and Fletcher, K (2002) Young adult follow-up of hyperactive children: self-reported psychiatric disorders, comorbidity, and the role of childhood conduct problems and teen cd. Journal of Abnormal Child Psychology 30, 463–475. doi: 10.1023/A:1019864813776 CrossRefGoogle ScholarPubMed
Grazioli, VS, Gmel, G, Rougemont-Bücking, A, Baggio, S, Daeppen, JB, Studer, J (2019) Attention deficit hyperactivity disorder and future alcohol outcomes: examining the roles of coping and enhancement drinking motives among young men. PLoS One 14, e0218469. doi: 10.1371/journal.pone.0218469 CrossRefGoogle ScholarPubMed
Greenfield, B, Hechtman, L and Weiss, G (1988) Two subgroups of hyperactives as adults: correlations of outcome. Canadian Journal of Psychiatry 33, 505–508. doi: 10.1177/070674378803300612 CrossRefGoogle Scholar
Gudjonsson, GH, Sigurdsson, JF, Sigfusdottir, ID and Young, S (2012) An epidemiological study of ADHD symptoms among young persons and the relationship with cigarette smoking, alcohol consumption and illicit drug use. Journal of Child Psychology and Psychiatry 53, 304–312. doi: 10.1111/j.1469-7610.2011.02489.x CrossRefGoogle ScholarPubMed
Hechtman, L and Weiss, G (1986) Controlled prospective fifteen years follow-up of hyperactives as adults: non-medical drug and alcohol use and anti-social behaviour. Canadian Journal of Psychiatry 31, 557–567. doi: 10.1177/070674378603100614 CrossRefGoogle ScholarPubMed
Hechtman, L, Weiss, G and Perlman, T (1984) Young adult outcome of hyperactive children who received long-term stimulant treatment. Journal of the American Academy of Child Psychiatry 23, 261–269. doi: 10.1016/S0002-7138(09)60501-X CrossRefGoogle ScholarPubMed
Hinshaw, SP, Owens, EB, Zalecki, C, Huggins, SP, Montenegro-Nevado, AJ, Schrodek, E and Swanson, EN (2012) Prospective follow-up of girls with attention-deficit/hyperactivity disorder into early adulthood: continuing impairment includes elevated risk for suicide attempts and self-injury. Journal of Consulting and Clinical Psychology 80, 1041–1051. doi: 10.1037/a0029451 CrossRefGoogle ScholarPubMed
Hodgkins, P, Arnold, LE, Shaw, M, Caci, H, Kahle, J, Woods, AG and Young, S (2012) A systematic review of global publication trends regarding long-term outcomes of ADHD. Frontiers in Psychiatry 2, 84. doi: 10.3389/fpsyt.2011.00084 CrossRefGoogle ScholarPubMed
Howell, DC, Huessy, HR and Hassuk, B (1985) Fifteen-year follow-up of a behavioral history of attention deficit disorder. Pediatrics 76, 185–190.Google ScholarPubMed
Italian Society of Child And Adolescent Neuropsychiatry [Società Italiana di Neuropsichiatria dell’Infanzia e dell’Adolescenza (SINPIA)] (2002) Linee-Guida per la Diagnosi e la Terapia Farmacologica del Disturbo da Deficit Attentivo con Iperattività (ADHD) in Età Evolutiva [Guidelines for the Diagnosis and Pharmacological Therapy of Attentive Deficit with Hyperactivity Disorder (ADHD) in Developmental Age/Childhood]. https://www.sinpia.eu/linee-guida/linee-guida-anno-2002/ Google Scholar
Jasper, HH, Solomon, P and Bradley, C (1938) Electroencephalographic analyses of behavior problem children. American Journal of Psychiatry 95, 641–658. doi: 10.1176/ajp.95.3.641 CrossRefGoogle Scholar
Karam, RG, Breda, V, Picon, FA, Rovaris, DL, Victor, MM, Salgado, CA, Vitola, ES, Silva, KL, Guimarães-da-Silva, PO, Mota, NR, Caye, A, Belmonte-de-Abreu, P, Rohde, LA, Grevet, EH and Bau, CHD (2015) Persistence and remission of ADHD during adulthood: a 7-year clinical follow-up study. Psychological Medicine 45, 2045–2056. doi: 10.1017/S0033291714003183 CrossRefGoogle ScholarPubMed
Karam, RG, Rovaris, DL, Breda, V, Picon, FA, Victor, MM, Salgado, CAI, Vitola, ES, Mota, NR, Silva, KL, Meller, M, Rohde, LA, Grevet, EH and Bau, CHD (2017)Trajectories of attention-deficit/hyperactivity disorder dimensions in adults. Acta Psychiatrica Scandinavica 136, 210–219. doi: 10.1111/acps.12757 CrossRefGoogle ScholarPubMed
Kessler, RC, Adler, L, Barkley, R, Biederman, J, Conners, CK, Demler, O, Faraone, SV, Greenhill, LL, Howes, MJ, Secnik, K, Spencer, T, Ustun, B, Walters, EE and Zaslavsky, AM (2006) The prevalence and correlates of adult ADHD in the United States: results from the national comorbidity survey replication. The American journal of Psychiatry 163, 716–723. doi: 10.1176/ajp.2006.163.4.716 CrossRefGoogle ScholarPubMed
Kessler, RC, Nelson, CB, McGonagle, KA, Edlund, MJ, Frank, RG and Leaf, PJ (1996) The epidemiology of co-occurring addictive and mental disorders: implications for prevention and service utilization. American Journal of Orthopsychiatry 66, 17–31. doi: 10.1037/h0080151 CrossRefGoogle ScholarPubMed
Klein, RG, Mannuzza, S, Olazagasti, MA, Roizen, E, Hutchison, JA, Lashua, EC and Castellanos, FX (2012) Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Archives of General Psychiatry 69, 1295–1303. doi: 10.1001/archgenpsychiatry.2012.271 CrossRefGoogle ScholarPubMed
Kuriyan, AB, Pelham, WE, Molina, BSG, Waschbusch, DA, Gnagy, EM, Sibley, MH, Babinski, DE, Walther, C, Cheong, J, Yu, J and Kent, KM (2013)Young adult educational and vocational outcomes of children diagnosed with ADHD. Journal of Abnormal Child Psychology 41, 27–41. doi: 10.1007/s10802-012-9658-z CrossRefGoogle ScholarPubMed
Lambert, NM and Hartsough, CS (1998) Prospective study of tobacco smoking and substance dependencies among samples of ADHD and non-ADHD participants. Journal of Learning Disabilities 31, 533–544. doi: 10.1177/002221949803100603 CrossRefGoogle ScholarPubMed
Lange, KW, Reichl, S, Lange, KM, Tucha, L and Tucha, O (2010) The history of attention deficit hyperactivity disorder. Attention Deficit and Hyperactivity Disorders 2, 241–255. doi: 10.1007/s12402-010-0045-8 CrossRefGoogle ScholarPubMed
Lara, C, Fayyad, J, de Graaf, R, Kessler, RC, Aguilar-Gaxiola, S, Angermeyer, M, Demytteneare, K, de Girolamo, G, Haro, JM, Jin, R, Karam, EG, Lépine, JP, Mora, ME, Ormel, J, Posada-Villa, J and Sampson, N (2009) Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biological Psychiatry 65, 46–54. doi: 10.1016/j.biopsych.2008.10.005 CrossRefGoogle ScholarPubMed
Lenartowicz, A and Loo, SK (2014) Use of EEG to diagnose ADHD. Current Psychiatry Reports 16, 498. doi: 10.1007/s11920-014-0498-0 CrossRefGoogle ScholarPubMed
Mannuzza, S, Klein, RG and Addalli, KA (1991) Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry 30, 743–751. doi: 10.1016/S0890-8567(10)80009-7 Google ScholarPubMed
Mannuzza, S, Klein, RG, Bessler, A, Malloy, P and La Padula, M (1993) Adult outcome of hyperactive boys: educational achievement, occupational rank, and psychiatric status. Archives of General Psychiatry 50, 565–576. doi: 10.1001/archpsyc.1993.01820190067007 CrossRefGoogle ScholarPubMed
Mannuzza, S, Klein, RG, Bessler, A, Malloy, P and La Padula, M (1998) Adult psychiatric status of hyperactive boys grown up. American Journal of Psychiatry 155, 493–498. doi: 10.1176/ajp.155.4.493 CrossRefGoogle ScholarPubMed
Mannuzza, S, Klein, RG and Moulton, JL 3rd (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Research 160, 237–246. doi: 10.1016/j.psychres.2007.11.003 CrossRefGoogle ScholarPubMed
Marangoni, C, De Chiara, L and Faedda, GL (2015) Bipolar disorder and ADHD: comorbidity and diagnostic distinctions. Current Psychiatry Reports 17, 604. doi: 10.1007/s11920-015-0604-y CrossRefGoogle ScholarPubMed
McIntyre, RS, Kennedy, SH, Soczynska, JK, Nguyen, HTT, Bilkey, TS, Woldeyohannes, HO, Nathanson, JA, Joshi, S, Chenq, JS, Benson, KM and Muzina, DJ (2010) Attention deficit/hyperactivity disorder in adults with bipolar disorder or major depressive disorder: results from the international mood disorders collaborative project. The Primary Care Companion to The Journal of Clinical Psychiatry 12, e1–e7. PCC.09m00861. doi: 10.4088/PCC.09m00861gry Google ScholarPubMed
Moffitt, TE, Houts, R, Asherson, P, Belsky, DW, Corcoran, DL, Hammerle, M, Harrington, H, Hogan, S, Meier, M, Polanczyk, GV, Poulton, R, Ramrakha, S, Sugden, K, Williams, B, Rohde, LA and Caspi, A (2015) Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a 4-decade longitudinal cohort study. American Journal of Psychiatry 172, 967–977. doi: 10.1176/appi.ajp.2015.14101266 CrossRefGoogle Scholar
Moher, D, Shamseer, L, Clarke, M, Ghersi, D, Liberati, A, Petticrew, M, Shekelle, P and Stewart, LA, PRISMA-P Group (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews 4, 1. doi: 10.1186/2046-4053-4-1 CrossRefGoogle ScholarPubMed
Mohr-Jensen, C, Müller Bisgaard, C, Boldsen, SK and Steinhausen, HC (2019) Attention-Deficit/Hyperactivity disorder in childhood and adolescence and the risk of crime in young adulthood in a Danish nationwide study. Journal of the American Academy of Child and Adolescent Psychiatry 58, 443–452. doi: 10.1016/j.jaac.2018.11.016 CrossRefGoogle Scholar
Molina, BSG, Howard, AL, Swanson, JM, Stehli, A, Mitchell, JT, Kennedy, TM, Epstein, JN, Arnold, LE, Hechtman, L, Vitiello, B and Hoza, B (2018) Substance use through adolescence in to early adulthood after childhood-diagnosed ADHD: findings from the MTA longitudinal study. Journal of Child Psychology and Psychiatry, and Allied Disciplines 59, 692–702. doi: 10.1111/jcpp.12855 CrossRefGoogle ScholarPubMed
Molina, BSG, Pelham, WE, Gnagy, EM, Thompson, AL and Marshal, MP (2007) Attention-deficit/hyperactivity disorder risk for heavy drinking and alcohol use disorder is age specific. Alcoholism: Clinical and Experimental Research 31, 643–654. doi: 10.1111/j.1530-0277.2007.00349.x Google ScholarPubMed
Mueser, KT, Crocker, AG, Frisman, LB, Drake, RE, Covell, NH and Essock, SM (2006) Conduct disorder and antisocial personality disorder in persons with severe psychiatric and substance use disorders. Schizophrenia Bulletin 32, 626–636. doi: 10.1093/schbul/sbj068 CrossRefGoogle ScholarPubMed
Muka, T, Glisic, M, Milic, J, Verhoog, S, Bohlius, J, Bramer, W, Chowdhury, R and Franco, OH (2020) A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. European Journal of Epidemiology 35, 49–60. doi: 10.1007/s10654-019-00576-5 CrossRefGoogle ScholarPubMed
Multimodal Treatment Study of Children with ADHD Cooperative Group [MTA] (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Archives of General Psychiatry 56, 1073–1086. doi: 10.1001/archpsyc.56.12.1073 CrossRefGoogle Scholar
National Center for Health Statistics (U.S.), Council on Clinical Classifications., Commission on Professional and Hospital Activities, & World Health Organization (1978) The International Classification of Diseases, 9th Revision, Clinical Modification: ICD-9-CM. Ann Arbor: World Health Organization.Google Scholar
National Institute for Health and Clinical Excellence [NICE] (2009) Attention Deficit Hyperactivity Disorder: The NICE Guideline on Diagnosis and Management of ADHD in Children, Young People and Adults. Leicester, UK: The British Psychological Society and The Royal College of Psychiatrists.Google Scholar
Nierenberg, AA, Miyahara, S, Spencer, T, Wisniewski, SR, Otto, MW, Simon, N, Pollack, MH, Ostacher, MJ, Yan, L, Siegel, R and Sachs, GS, STEP-BD Investigators (2005) Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD Participants. Biological Psychiatry 57, 1467–1473. doi: 10.1016/j.biopsych.2005.01.036 CrossRefGoogle ScholarPubMed
Notzon, DP, Pavlicova, M, Glass, A, Mariani, JJ, Mahony, AL, Brooks, DJ and Levin, FR (2020) ADHD is highly prevalent in patients seeking treatment for cannabis use disorders. Journal of Attention Disorders 24, 1487–1492. doi: 10.1177/1087054716640109 CrossRefGoogle ScholarPubMed
Nussbaum, NL (2012) ADHD and female specific concerns: a review of the literature and clinical implications. Journal of Attention Disorders 16, 87–100. doi: 10.1177/1087054711416909 CrossRefGoogle ScholarPubMed
Paternitè, CE, Loney, J, Salisbury, H and Whaley, MA (1999) Childhood inattention-over activity, aggression, and stimulant medication history as predictors of young adult outcomes. Journal of Child Adolescent Psychopharmacology 9, 169–184. doi: 10.1089/cap.1999.9.169 CrossRefGoogle ScholarPubMed
Pawaskar, M, Fridman, M, Grebla, R and Madhoo, M (2020) Comparison of quality of life, productivity, functioning and self-esteem in adults diagnosed with ADHD and with symptomatic ADHD. Journal of Attention Disorders 24, 136–144. doi: 10.1177/1087054719841129 CrossRefGoogle ScholarPubMed
Philipp-Wiegmann, F, Rosler, M, Clasen, O, Zinnow, T, Retz-Junginger, F and Retz, W (2018) ADHD modulates the course of delinquency: a 15-year follow-up study of young incarcerated man. European Archives of Psychiatry and Clinical Neuroscience 268, 391–399. doi: 10.1007/s00406-017-0816-8 CrossRefGoogle ScholarPubMed
Pliszka, S (2007) Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. AACAP Work Group on Quality Issues. Journal of American Academy of Child and Adolescent Psychiatry 46, 894–921. doi: 10.1097/chi.0b013e318054e724 CrossRefGoogle Scholar
Polanczyk, GV, Willcutt, EG Salum, GA, Kieling, C and Rohde, LA (2014) ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. The International Journal of Epidemiology 43, 434–442. doi: 10.1093/ije/dyt261 CrossRefGoogle ScholarPubMed
Powell, V, Riglin, L, Hammerton, G, Eyre, O, Martin, J, Anney, R, Thapar, A and Rice, F (2020) What explains the link between childhood ADHD and adolescent depression? Investigating the role of peer relationships and academic attainment. European Child & Adolescent Psychiatry 29, 1581–1591. doi: 10.1007/s00787-019-01463-w 18.CrossRefGoogle ScholarPubMed
Ramtekkar, UP, Reiersen, AM, Todorov, AA and Todd, RD (2010) Sex and age differences in attention-deficit/hyperactivity disorder symptoms and diagnoses: implications for DSM-V and ICD-11. Journal of American Academy of Child and Adolescent Psychiatry 49, 217–228, e283.Google ScholarPubMed
Rasmussen, P and Gillberg, C (2000) Natural outcome of ADHD with developmental coordination disorder at age 22 years: a controlled, longitudinal, community-based study. Journal of the American Academy of Child and Adolescent Psychiatry 39, 1424–1431. doi: 10.1097/00004583-200011000-00017 CrossRefGoogle ScholarPubMed
Realmuto, GM, Winters, KC, August, GJ, Lee, S, Fahnhorst, T and Botzet, A (2009) Drug use and psychosocial functioning of a community derived sample of adolescents with childhood ADHD. Journal of Child and Adolescent Substance Abuse 18, 172–192. doi: 10.1080/10678280902724176 CrossRefGoogle ScholarPubMed
Ruiz-Goikoetxea, M, Cortese, S, Aznarez-Sanado, M, Magallón, S, Alvarez Zallo, N, Luis, EO, Castro-Manglano, P, Soutullo, C and Arrondo, G (2018) Risk of unintentional injuries in children and adolescents with ADHD and the impact of ADHD medications: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 84, 3–71. doi: 10.1016/j.neubiorev.2017.11.007 CrossRefGoogle ScholarPubMed
Sachs, GS, Baldassano, CF, Truman, CJ and Guille, C (2000) Comorbidity of attention deficit hyperactivity disorder with early- and late-onset bipolar disorder. American Journal of Psychiatry 157, 466–468. doi: 10.1176/appi.ajp.157.3.466 CrossRefGoogle ScholarPubMed
Sagar, R, Dandona, R, Gururaj, G, Dhaliwal, RS, Singh, A, Ferrari, A, Dua, T, Ganguli, A, Varghese, M, Chakma, JK, Kumar, GA, Shaji, KS, Ambekar, A, Rangaswamy, T, Vijayakumar, L, Agarwal, V, Krishnankutty, RP, Bhatia, R, Charlson, F, Chowdhary, N, Erskine, HE, Glenn, SD, Krish, V, Mantilla-Herrera, AM, Mutreja, P, Odell, CM, Pal, Pramod K, Sanjay, Prakash, Damian, Santomauro, D K, Shukla, Ravinder, Singh, Singh, RKL, Thakur, JS, ThekkePurakkal, AS, Varghese, CM, Reddy, KS, Swaminathan, S, Whiteford, H, Bekedam, HJ, Murray, CJL, Vos, T, Dandona, L (2020) The burden of mental disorders across the states of India: the Global Burden of Disease Study 1990-2017. Lancet Psychiatry 7, 148–161. doi: 10.1016/S2215-0366(19)30475-4 CrossRefGoogle Scholar
Satterfield, JH, Faller, KJ, Crinella, FM, Schell, AM, Swanson, JM and Homer, LD (2007) A 30-year prospective follow-up study of hyperactive boys with conduct problems: adult criminality. Journal of the American Academy of Child and Adolescent Psychiatry 46, 601–610. doi: 10.1097/chi.0b013e318033ff59 CrossRefGoogle ScholarPubMed
Sayal, K, Prasad, V, Daley, D, Ford, T and Coghill, D (2018) ADHD in children and young people: prevalence, care pathways, and service provision. The Lancet Psychiatry 5, 175–186. doi: 10.1016/S2215-0366(17)30167-0 CrossRefGoogle Scholar
Shaw, M, Hodgkins, P, Caci, H, Young, S, Kahle, J, Woods, AG and Arnold, LE (2012) A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC Medicine 10, 99. doi: 10.1186/1741-7015-10-99 CrossRefGoogle ScholarPubMed
Shyu, YC, Yuan, SS, Lee, SY, Yang, CJ, Yang, KC, Lee, TL and Wang, LJ (2015) Attention-deficit/hyperactivity disorder, methylphenidate use and the risk of developing schizophrenia spectrum disorders: A nationwide population-based study in Taiwan. Schizophrenia Research 168, 161–167. doi: 10.1016/j.schres.2015.08.033 CrossRefGoogle ScholarPubMed
Sibley, MH, Mitchell, JT and Becker, SP (2016) Method of adult diagnosis influences estimated persistence of childhood ADHD: a systematic review of longitudinal studies. The Lancet Psychiatry 3, 1157–1165. doi: 10.1016/S2215-0366(16)30190-0 Erratum in Lancet Psychiatry. 2016;3(12):e22. https://doi.org/10.1016/S2215-0366(16)30384-4.CrossRefGoogle ScholarPubMed
Sibley, MH, Pelham, WE, Molina, BSG, Gnagy, EM, Waxmonsky, JG, Waschbusch, DA, Derefinko, KJ, Wymbs, BT, Garefino, AC, Babinski, DE and Kuriyan, AB (2012) When diagnosing ADHD in young adults emphasize informant reports, DSM items, and impairment. Journal of Consulting and Clinical Psychology 80, 1052–1061. doi: 10.1037/a0029098 CrossRefGoogle ScholarPubMed
Simon, V, Czobor, P, Bálint, S, Mészáros, A and Bitter, I (2009) Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. British Journal Psychiatry 194, 204–211. doi: 10.1192/bjp.bp.107.048827.CrossRefGoogle ScholarPubMed
Song, P, Zha, M, Yang, Q, Zhang, Y, Li, X and Rudan, I (2021) The prevalence of adult attention-deficit hyperactivity disorder: a global systematic review and meta-analysis. Journal of Global Health 11, 04009. doi: 10.7189/jogh.11.04009.CrossRefGoogle ScholarPubMed
Sowell, ER, Thompson, PM, Welcome, SE, Henkenius, AL, Toga, AW and Peterson, BS (2003) Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder. Lancet 362, 1699–1707. doi: 10.1016/S0140-6736(03)14842-8 CrossRefGoogle ScholarPubMed
Storebø, OJ, Ramstad, E, Krogh, HB, Nilausen, TD, Skoog, M, Holmskov, M, Rosendal, S,Growth, C, Magnusson, FL, Moreira-Maia, CR, Gillies, D, Rasmussen, KB, Gauci, D, Zwi, M, Kirubakaran, R, Forsbøl, B, Simonsen, E and Gluud, C (2015) Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD009885.pub2 CrossRefGoogle Scholar
Swanson, JM, Kraemer, HC, Hinshaw, SP, Arnold, LE, Conners, CK, Abikoff, HB, Clevenger, W, Davies, M, Elliott, GR, Greenhill, LL, Hechtman, L, Hoza, B, Jensen, PS, March, JS, Newcorn, JH, Owens, EB, Pelham, WE, Schiller, E, Severe, JB, … Wu, M (2001) Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. Journal of the American Academy of Child & Adolescent Psychiatry 40, 168–179. doi: 10.1097/00004583-200102000-00011 CrossRefGoogle Scholar
Thomas, R, Sanders, S, Doust, J, Beller, E and Glasziou, P (2015) Prevalence of attention-deficit/hyperactivity disorder: a systematic review and metaanalysis. Pediatrics 135, e994–e1001. doi: 10.1542/peds.2014-3482 CrossRefGoogle Scholar
Torgersen, T, Gjervan, B, Lensing, MB, Rasmussen, K (2016) Optimal management of ADHD in older adults. Neuropsychiatric Disease and Treatment 12, 79–87. doi: 10.2147/NDT.S5927 CrossRefGoogle ScholarPubMed
Uchida, M, Spencer, TJ, Faraone, SV and Biederman, J (2018) Adult Outcome of ADHD: an overview of results from the MGH longitudinal family studies of pediatrically and psychiatrically referred youth with and without ADHD of both sexes. Journal of Attention Disorders 22, 523–534. doi: 10.1177/1087054715604360 CrossRefGoogle ScholarPubMed
van Emmerik-van Oortmerssen, K, van de Glind, G, van den Brink, W, Smit, F, Crunelle, CL, Swets, M, Schoevers, RA (2012) Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis. Drug and Alcohol Dependence 122, 11–19. doi: 10.1016/j.drugalcdep.2011.12.007 CrossRefGoogle ScholarPubMed
van Lieshout, M, Luman, M, Twisk, JWR, van Ewijk, H, Groenman, AP, Thissen, AJAM, Faraone, SV, Heslenfeld, DJ, Hartman, CA, Hoekstra, PJ, Franke, B, Buitelaar, JK, Rommelse, NNJ and Oosterlaan, J (2016) A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood. European Child and Adolescent Psychiatry 25, 1007–1017. doi: 10.1007/s00787-016-0820-y CrossRefGoogle Scholar
Vitiello, B, Perez Algorta, G, Arnold, LE, Howard, AL, Stehli, A and Molina, BS (2017) Psychotic symptoms in attention-deficit/hyperactivity disorder: an analysis of the MTA database. Journal of the American Academy of Child & Adolescent Psychiatry 56, 336–343. doi: 10.1016/j.jaac.2017.01.016 CrossRefGoogle ScholarPubMed
Wilens, TE (2007) The nature of the relationship between attention-deficit/hyperactivity disorder and substance use. Journal of Clinical Psychiatry 68(Suppl 11), 4–8.Google ScholarPubMed
Wittchen, HU, Jacobi, F, Rehm, J, Gustavsson, A, Svensson, M, Jönsson, B, Olesen, J, Allgulander, C, Alonso, J, Faravelli, C, Fratiglioni, L, Jennum, P, Lieb, R, Maercker, A, van Os, J, Preisig, M, Salvador-Carulla, L, Simon, R and Steinhausen, HC (2011) The size and burden of mental disorders and other disorders of the brain in Europe 2010. European Neuropsychopharmacology 21, 655–679. doi: 10.1016/j.euroneuro.2011.07.018 CrossRefGoogle ScholarPubMed
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. https://apps.who.int/iris/handle/10665/37958 Google Scholar
Young, S, Gudjonsson, G, Chitsabesan, P, Colley, B, Farrag, E, Forrester, A, Hollingdale, J, Kim, K, Lewis, A, Maginn, S, Mason, P, Ryan, S, Smith, J, Woodhouse, E and Asherson, P (2018) Identification and treatment of offenders with attention-deficit/hyperactivity disorder in the prison population: a practical approach based upon expert consensus. BMC Psychiatry 18. 281. doi: 10.1186/s12888-018-1858-9 CrossRefGoogle ScholarPubMed
Zamboni, L, Marchetti, P, Congiu, A, Giordano, R, Fusina, F, Carli, S, Centoni, F, Verlato, G and Lugoboni, F (2021) ASRS questionnaire and tobacco use: not just a cigarette. A screening study in an Italian Young Adult Sample. International Journal of Environmental Research and Public Health 12, 2920. doi: 10.3390/ijerph18062920 CrossRefGoogle Scholar
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