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Changes in immune and endocrine systems in posttraumatic stress disorder – prospective study

Published online by Cambridge University Press:  24 June 2014

Anđelko Vidović ,
Maja Vilibić ,
Ante Sabioncello ,
Katja Gotovac ,
Sabina Rabatić ,
Vera Folnegović-Šmalc  and
Dragan Dekaris
Anđelko Vidović
Affiliation:
University Hospital Dubrava, Department of Psychiatry, Referral Centre for the Stress-Related Disorders, Zagreb, Croatia
Maja Vilibić
Affiliation:
University Department of Psychiatry, Psychiatric Hospital Vrapce, Zagreb, Croatia
Ante Sabioncello
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Katja Gotovac
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Sabina Rabatić
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Vera Folnegović-Šmalc
Affiliation:
University Department of Psychiatry, Psychiatric Hospital Vrapce, Zagreb, Croatia
Dragan Dekaris
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
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Abstract:

Introduction and aim: Posttraumatic stress disorder (PTSD) is associated with increased medical morbidity, particularly from the autoimmune and cardiovascular diseases. Changes in the endocrine and immune system are key mediators in this process. The aim of our study was to investigate weather hormones (cortisol and prolactin), proinflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)), components of HPA-axis (lymphocyte expression of glucocorticoid receptor (GR)), immune function (natural killer cell cytotoxicity) and peripheral blood percentages of various lymphocyte subpopulations (T cells, helper T cells, cytotoxic T cells, B cells and natural killer cells) change in patients with posttraumatic stress disorder over time.

Type
Psychoimmunology Symposium: The Impact of Dysfunctional Endocrine and Immune Systems on Psychiatric Disorders
Information
Acta Neuropsychiatrica , Volume 21 , Issue S2: Special Issue: Abstracts of 49th Neuropsychiatric Pula Congress, 17-20 June 2009, Pula, Croatia , June 2009 , pp. 46 - 50
Copyright
Copyright © 2009 John Wiley & Sons A/S

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