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A blinded, placebo-controlled randomized trial of low-dose risperidone, intensive psychological treatment and befriending in young people at risk of psychotic disorder: baseline characteristics of the sample

Published online by Cambridge University Press:  24 June 2014

P McGorry ,
A Yung ,
S Francey ,
L Phillips  and
B Nelson
P McGorry
Affiliation:
ORYGEN Research Centre
A Yung
Affiliation:
ORYGEN Research Centre
S Francey
Affiliation:
ORYGEN Research Centre
L Phillips
Affiliation:
ORYGEN Research Centre Department of Psychology, The University of Melbourneand ORC, Melbourne, Australia
B Nelson
Affiliation:
ORYGEN Research Centre
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Abstract

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Type
Abstracts from ‘Brainwaves’— The Australasian Society for Psychiatric Research Annual Meeting 2006, 6–8 December, Sydney, Australia
Information
Acta Neuropsychiatrica , Volume 18 , Issue 6 , December 2006 , pp. 261
Copyright
Copyright © 2006 Blackwell Munksgaard

Background:

Intervention during the prodromal phase of psychotic disorder has become an important focus of early intervention research.

Method:

The PACE Clinic, ORYGEN Youth Health, has been conducting a blinded randomized controlled trial (RCT) comparing the effectiveness of low-dose risperidone (0.5–2.0 mg/day) and intensive CBT-based psychological treatment vs. placebo and intensive CBT-based psychological treatment vs. placebo and a control psychological treatment (befriending). The trial consists of a 12-month treatment phase, followed by a 12-month follow-up phase. The primary outcome of interest is the proportion of patients meeting onset of psychosis criteria during the treatment and follow-up phases.

Results:

The current presentation will describe baseline characteristics of the sample. About 119 participants (mean age = 18.36 years, men = 41.2%) meeting ultrahigh-risk criteria for psychotic disorder were randomized to the three treatment groups. Baseline characteristics will be compared between 1) the three treatment groups and 2) the treatment groups and a monitoring group (n = 83, mean age = 18.45 years, men = 41%), who received ‘treatment as usual’.

Conclusion:

Pending.