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Association of schizophrenia with T102C (rs6313) and 1438 A/G (rs6311) polymorphisms of HTR2A gene

Published online by Cambridge University Press:  29 May 2013

Saliha Handan Yildiz ,
Asli Akilli ,
Erman Bagcioglu ,
Mujgan Ozdemir Erdogan ,
Kerem Senol Coskun ,
Ahmet Hamdi Alpaslan ,
Burak Subasi  and
Evrim Suna Arikan Terzi
Saliha Handan Yildiz*
Affiliation:
Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Asli Akilli
Affiliation:
Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Erman Bagcioglu
Affiliation:
Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Mujgan Ozdemir Erdogan
Affiliation:
Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Kerem Senol Coskun
Affiliation:
Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Ahmet Hamdi Alpaslan
Affiliation:
Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Burak Subasi
Affiliation:
Elazıg Training and Research Hospital, Elazıg, Turkey
Evrim Suna Arikan Terzi
Affiliation:
Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
*
Dr. Saliha Handan Yildiz, Department of Medical Genetic, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. Tel: +90-505 5044162; Fax: +90-272 2463300; E-mail: [email protected]
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Abstract

Objective

The aim of this study is to investigate whether there were any associations between the T102C and 1438 A/G polymorphisms of the 5-HT2A receptor gene and schizophrenia. We conducted a case–control study of the T102C and 1438 A/G polymorphisms in Turkish patients.

Methods

We compared genotypes and allele frequencies of T102C and 1438 A/G polymorphisms of 5-HT2A receptor gene in 102 patients with schizophrenia diagnosed, according to DSM-IV, and 107 healthy controls. Genotyping was performed by real-time polymerase chain reaction.

Results

We found no significant association between schizophrenia and genotypic or allele frequencies of HTR2A gene 102T/C (rs6313) and 1438 A/G (6311) polymorphisms. However, comparison of HTR2A gene 102 T/C and 1438 A/G polymorphisms in terms of genotypic and allele frequencies between the two patient groups, with or without a family history of schizophrenia, shows that T- and A-allele frequencies were significantly higher (p < 0.05) in the case group that has a history of schizophrenia in their family.

Conclusion

In conclusion, our results do not support the hypothesis that the T102C and 1438 A/G polymorphisms in the 5-HT2A receptor gene are associated with schizophrenia, but further studies in a larger sample are needed.

Keywords

HTR2ApolymorphismschizophreniaT102C1438 A/G
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 25 , Issue 6 , December 2013 , pp. 342 - 348
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2013 

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