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Aripiprazole-induced tardive dyskinesia treated with quetiapine: a case report

Published online by Cambridge University Press:  24 June 2014

Nesrin B. Tomruk ,
Omer Saatcioglu ,
Eren Yildizhan  and
Nihat Alpay
Nesrin B. Tomruk
Affiliation:
1st Psychiatry Clinic, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey
Omer Saatcioglu
Affiliation:
3rd Psychiatry Clinic, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey Clinic of Early Psychosis, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey
Eren Yildizhan
Affiliation:
1st Psychiatry Clinic, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey
Nihat Alpay
Affiliation:
1st Psychiatry Clinic, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey
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Extract

Tomruk NB, Saatcioglu O, Yildizhan E, Alpay N. Aripiprazole-induced tardive dyskinesia treated with quetiapine: a case report.

Background: Tardive dyskinesia (TD) is a serious, potentially irreversible side effect of antipsychotics. Although the risk is smaller, atypical antipsychotics still pose a risk. Aripiprazole is an atypical antipsychotic with a unique mechanism of action. It has a partial agonistic effect on the presynaptic D2 dopamine autoreceptor and antagonistic effect at postsynaptic D2 receptors.

Method: There have been a few case reports of aripiprazole-induced TD. A case of aripiprazole-induced TD successfully treated with another atypical antipsychotic, quetiapine, is described and discussed in line with the recent literature.

Results: TD showed rapid improvement with discontinuation of aripiprazole and initiation of quetiapine.

Conclusion: Further studies are needed to ascertain the differential effects and side effects of second-generation antipsychotics in terms of TD.

Keywords

antipsychoticpsychiatric disorderspsychosistardive dyskinesia
Type
Case Reports
Information
Acta Neuropsychiatrica , Volume 23 , Issue 4 , August 2011 , pp. 188 - 190
Copyright
Copyright © Cambridge University Press 2011

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