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An open trial of Omega-3 fatty acids for depression in pregnancy*

Published online by Cambridge University Press:  24 June 2014

Marlene P. Freeman ,
Joseph R. Hibbeln ,
Katherine L. Wisner ,
Marcy Watchman  and
Alan J. Gelenberg
Marlene P. Freeman*
Affiliation:
Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA
Joseph R. Hibbeln
Affiliation:
National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
Katherine L. Wisner
Affiliation:
Department of Psychiatry, Obstetrics and Gynecology, Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA
Marcy Watchman
Affiliation:
Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA
Alan J. Gelenberg
Affiliation:
Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA
*
Marlene P. Freeman, Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, 1501 N. Campbell Avenue, PO Box 245002, Tucson, AZ 85724-5002, USA. Tel: +1 520 626 6509; Fax: +1 520 626 6050; E-mail: [email protected]
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Abstract

Objective:

In this flexible-dose, open-label trial, we examined the efficacy of omega-3 fatty acids for the treatment of depression during pregnancy.

Methods:

Fifteen pregnant women with major depressive episodes participated. Subjects initially received two capsules per day [0.93 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)]; the dose could be increased by one capsule per day every 2 weeks to a maximal dose of 2.8 g. Subjects were assessed with the Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD).

Results:

Average duration of participation in this treatment trial was 8.3 weeks (SD ± 7.1). Average final dose of EPA + DHA in this flexible dose trial was 1.9 g per day (±0.5). The mean reduction in EPDS scores was 40.9% (SD ± 21.9); the mean decrease in HRSD score was 34.1% (SD ± 27.1).

Conclusions:

This open trial provides data to support the need for randomized controlled dose-finding trials of omega-3 fatty acids in major depressive episodes during pregnancy.

Keywords

fatty acidsmood disordersnutritionOmega-3postpartumpregnancyunipolar depression
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 1 , February 2006 , pp. 21 - 24
Copyright
Copyright © 2006 Blackwell Munksgaard

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References

Evans, J, Heron, J, Francomb, H, Oke, S, Golding, J. Cohort study of depressed mood during pregnancy and after childbirth. BMJ 2001;323: 257–260. CrossRefGoogle ScholarPubMed
Wadhwa, PD, Sandman, CA, Porto, M, Dunkel-Schetter, C, Garite, TJ. The association between prenatal stress and infant birth weight and gestational age at birth: a prospective investigation. Am J Obstet Gynecol 1993;169: 858–865. CrossRefGoogle ScholarPubMed
Istvan, J. Stress, anxiety, and birth outcomes: a critical review of the evidence. Psychol Bull 1986;100: 331–348. CrossRefGoogle ScholarPubMed
Costei, AM, Kozer, E, Ho, T, Ito, S, Koren, G. Perinatal outcome following third trimester exposure to paroxetine. Arch Pediatr Adolesc Med 2002;156 (1): 1129–1132. CrossRefGoogle ScholarPubMed
Mohan, CG, Moore, JJ. Fluoxetine toxicity in a preterm infant. J Perinatol 2000;20 (7):445–446. CrossRefGoogle Scholar
Nordeng, H, Lindemann, R, Perminov, KV, Reikvam, A. Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors. Acta Paediatr 2001;90 (3):288–291. CrossRefGoogle ScholarPubMed
Cohen, LS, Heller, VL, Bailey, JW, Grush, L, Ablon, JS, Bouffard, SM. Birth outcomes following prenatal exposure to fluoxetine. Biol Psychiatry 2000;48 (10):996–1000. CrossRefGoogle ScholarPubMed
Otto, SJ, Van Houwelingen, AC, Antal, Met al. Maternal and neonatal essential fatty acid status in phospholipids: an international comparative study. Eur J Clin Nutr 1997;51: 232–242. CrossRefGoogle ScholarPubMed
Min, Y, Ghebremeskel, K, Crawford, MAet al. Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. Int J Vitam Nutr Res 2000;70: 70–75. CrossRefGoogle ScholarPubMed
Holman, RT, Johnson, SB, Ogburn, PL. Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation. Proc Natl Acad Sci USA 1991;88: 4835–4839. CrossRefGoogle ScholarPubMed
Benisek, D, Shabert, J, Skornik, R. Dietary intake of polyunsaturated fatty acids by pregnant or lactating women in the United States. Obstet Gynecol 2000;95: 77–78. CrossRefGoogle Scholar
Araya, J, Rojas, M, Fernandez, P, Matenluna, A. Essential fatty acid content of maternal erythrocyte phospholipids. A study in pertern and full-term human newborns. Rev Med Chil 1998;126: 391–396. Google ScholarPubMed
Olsen, SF, Sorensen, JD, Secher, NJet al. Randomised controlled trial of effect of fish oil supplementation on pregnancy duration. Lancet 1992;339: 1003–1004. CrossRefGoogle ScholarPubMed
Williams, MA, Zingham, RW, King, IB, Zebelman, AM. Omega-3 fatty acids in maternal erythrocytes and risk of preeclampsia. Epidemiology 1995;6: 232–237. CrossRefGoogle ScholarPubMed
Petridou, E, Koussouri, M, Toupadaki, Net al. Diet during pregnancy and the risk of cerebral palsy. Br J Nutr 1998;79: 407–412. CrossRefGoogle ScholarPubMed
Hoffman, DR, Uauy, R. Essentiality of dietary n-3 fatty acids for premature infants: plasma and red blood cell fatty acid composition. Lipids 1992;27: 886–895. CrossRefGoogle ScholarPubMed
Foreman-Van Drongelen, M, Van Houwelingen, AC, Kester, ADM, Blanco, CE, Hasaart, THM, Hornstra, G. Influence of feeding artificial-formula milks containing docohexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. Br J Nutr 1996;76: 649–667. CrossRefGoogle Scholar
ISSFAL Board Of Directors. Recommendations for the essential fatty acid requirement for infant formula. ISSFAL Newsletter 1994;1: 4–5. Google Scholar
FAO/WHO Expert Committee. The role of essential fatty acids in neural development: implications for perinatal nutrition. Am J Clin Nutr 1994;57: 703–710. Google Scholar
Aggett, PJ, Haschke, F, Heine, Wet al. ESPGAN comment of the content and composition of lipids in infant formula. Acta Paediatr Scand 1991;80: 887–896. CrossRefGoogle Scholar
British Nutrition Foundation. Unsaturated fatty acids: nutritional and physiologycal significance. London: Chapman & Hall, 1992. Google Scholar
Hibbeln, JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord 2002;69: 15–29. CrossRefGoogle ScholarPubMed
De Vriese, SR, Christophe, AB, Maes, M. Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: further evidence that lowered n-PUFAs are related to major depression. Life Sci 2003;73 (25):3181–3187. CrossRefGoogle ScholarPubMed
Horrobin, DF, Peet, M. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry 2002;59 (10):913–919. Google Scholar
Nemets, B, Stahl, Z, Belmaker, RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002;159: 477–479. CrossRefGoogle ScholarPubMed
Su, KP, Huang, SY, Chiu, CCet al. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13: 267–271. CrossRefGoogle ScholarPubMed
Marangell, LB, Martinez, JM, Zboyan, HA, Kertz, B, Kim, HF, Puryear, LJ. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160 (5):996–998. CrossRefGoogle ScholarPubMed
Chiu, CC, Huang, SY, Shen, WW, Su, KP. Omega-3 fatty acids for depression in pregnancy. Am J Psychiatry 2003;160 (2):385. CrossRefGoogle ScholarPubMed
Eritsland, J, Arnesen, H, Seljeflot, I, Kierulf, P. Long-term effects of n-3 polyunsaturated fatty acids on haemostatic variables and bleeding episodes in patients with coronary artery disease. Blood Coagul Fibrinolysis 1995;6 (1):17–22. CrossRefGoogle ScholarPubMed
Mueller, BA, Talbert, RL, Tegeler, CH, Prihoda, TJ. The bleeding time effects of a single dose of aspirin in subjects receiving omega-3 fatty acid dietary supplementation. J Clin Pharmacol 1991;31 (2):185–190. CrossRefGoogle ScholarPubMed
Buckley, MS, Goff, AD, Knapp, WE. Fish oil interaction with warfarin. Ann Pharmacother 2004;38 (1): 50–52. CrossRefGoogle ScholarPubMed
Eisenberg, DM, Davis, RB, Ettner, SLet al. Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey. JAMA 1998;280 (18):1569–1575. CrossRefGoogle ScholarPubMed