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Adjunctive cognitive remediation for schizophrenia using yoga: an open, non-randomised trial

Published online by Cambridge University Press:  24 June 2014

Triptish Bhatia ,
Akhilesh Agarwal ,
Gyandeepak Shah ,
Joel Wood ,
Jan Richard ,
Raquel E. Gur ,
Ruben C. Gur ,
Vishwajit L. Nimgaonkar ,
Sati Mazumdar  and
Smita N. Deshpande
Triptish Bhatia*
Affiliation:
Training Program for Psychiatric Genetics in India, Post-graduate Institute for Medical Education and Research, Dr Ram Manohar Lohia Hospital, Delhi, India
Akhilesh Agarwal
Affiliation:
Yoga and Major Mental Illness, Department of Psychiatry, PGIMER-Dr RMLH, Delhi, India
Gyandeepak Shah
Affiliation:
Yoga and Major Mental Illness, Department of Psychiatry, PGIMER-Dr RMLH, Delhi, India
Joel Wood
Affiliation:
Biostatistics and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Jan Richard
Affiliation:
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Raquel E. Gur
Affiliation:
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Ruben C. Gur
Affiliation:
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Vishwajit L. Nimgaonkar
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
Sati Mazumdar
Affiliation:
Biostatistics and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Smita N. Deshpande
Affiliation:
Post-graduate Institute for Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi, India
*
Triptish Bhatia, Training Program for Psychiatric Genetics in India, Post-graduate Institute for Medical Education and Research, Dr Ram Manohar Lohia Hospital, Delhi, India. Tel: +91-11-23404363; Fax: +91-11-23342122; E-mail: [email protected]
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Extract

Background: Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated.

Objective: To evaluate the adjunctive YT for cognitive domains impaired in SZ.

Methods: Patients with SZ received YT or treatment as usual (TAU; n = 65, n = 23, respectively). Accuracy and speed for seven cognitive domains were assessed using a computerised neurocognitive battery (CNB), thus minimising observer bias. Separately, YT was evaluated among patients with bipolar I disorder (n = 40), major depressive disorder (n = 37) and cardiology outpatients (n = 68). All patients also received routine pharmacotherapy. Patients were not randomised to YT or TAU.

Results: In comparison with the SZ/TAU group, the SZ/YT group showed significantly greater improvement with regard to measures of attention following corrections for multiple comparisons; the changes were more prominent among the men. In the other diagnostic groups, differing patterns of improvements were noted with small-to-medium effect sizes.

Conclusions: Our initial analyses suggest nominally significant improvement in cognitive function in SZ with adjunctive therapies such as YT. The magnitude of the change varies by cognitive domain and may also vary by diagnostic group.

Keywords

cognitionschizophreniayoga
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 2 , April 2012 , pp. 91 - 100
Copyright
Copyright © Cambridge University Press 2011

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Supporting Information

The following Supporting information is available for this article:

Table S1. Effect sizes of changes in pre- and post-therapy values for cognitive domains in the schizophrenia yoga therapy (21 days) and treatment as usual groups (2 months)

Table S2. Effect sizes of changes in pre- and post-therapy values for cognitive domains in the bipolar disorder yoga therapy

Table S3. Effect sizes of changes in pre- and post-therapy values for cognitive domains in the major depressive disorder yoga therapy

Table S4. Effect sizes of changes in pre- and post-therapy values for cognitive domains in the cardiac controls yoga therapy

Table S5. Effect sizes of changes in pre- and post-therapy values for cognitive domains in the schizophrenia yoga therapy (2 months) and treatment as usual groups (2 months)

Additional Supporting information may be found in the online version of this article.

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