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The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan

Published online by Cambridge University Press:  24 June 2014

Hayato Terayama
Affiliation:
Department of Neurophysiology, Graduate School of Azabu University, Sagamihara-shi, Kanagawa First Department of Anatomy, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan
Takahiro Takimoto
Affiliation:
Department of Neurophysiology, Graduate School of Azabu University, Sagamihara-shi, Kanagawa
Isao Fukunishi
Affiliation:
Department of Liaison Psychiatry and Psychosomatics, Tokyo Institute of Psychiatry, Setagaya-ku, Tokyo
Masahiro Itoh
Affiliation:
First Department of Anatomy, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan
Kazuhiko Iwahashi*
Affiliation:
Department of Neurophysiology, Graduate School of Azabu University, Sagamihara-shi, Kanagawa Health Administration Center, Azabu University, Sagamihara-shi, Kanagawa
*
Health Administration Center, University of Azabu, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229–8501, Japan. Tel./Fax: 81-42-769-1930; E-mail: [email protected]

Abstract

In the past, there have been many epidemiological and genetic studies of mood disorders, schizophrenia, and alcohol dependence, and in this study, the human serotonin 2A receptor (5-HTR2A) polymorphism was examined in 80 patients with mood disorders, 50 patients with schizophrenia and 41 patients with alcohol dependence. 5-HTR is related to affectivity, regulation, and pharmacologic effects of antidepressant, anti-anxiety and antipsychotic medications. The polymorphism in 5-HTR2A (102T/C, −1438 A/G) was identified by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP). The results suggest that 5-HTR2A (102T/C, −1438G/A) polymorphism might not be associated with susceptibility to schizophrenia or mood disorders, and it might not be a risk factor contributing to alcohol dependency. We found that the 102T/C polymorphism was in linkage disequilibrium with the −1438G/A polymorphism in psychosis (mood disorder, schizophrenia, and alcohol dependence) and in health controls. Further studies are needed to determine whether or not the novel serotonin receptor (5-HTR) polymorphism reflects the pathogenesis of schizophrenia, mood disorders, and alcohol dependence.

Type
Research Article
Copyright
Copyright © 2003 Blackwell Munksgaard

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References

Kroeze, WK, Roth, BL.The molecular biology of serotonin receptors, therapeutic implications for the interface of mood and psychosis. Biol Psychiatry 1998;44: 11281142.CrossRefGoogle ScholarPubMed
Hoyer, D, Clarke, DE, Fozard, JR.International Union of Pharmacology Classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 1994;46: 158193. Google Scholar
Eison, AS, Mullins, UL.Regulation of central 5-HT2A receptors, a review of in vivo studies. Behav Brain Res 1996;73: 177181.CrossRefGoogle ScholarPubMed
Schmidt, CJ, Sorensen, SM, Kehne, JH, Carr, AA, Palfreyman, MG.The role of 5-HT2A receptors in antipsychotic activity. Life Sci 1995;56: 22092222.CrossRefGoogle ScholarPubMed
Lai, H, Prather, PL, Rezazadeh, SM.Potential role of 5HT1C and/or 5HT2 receptors in the mianserin-induced prevention of anxiogenic behaviors occurring during ethanol withdrawal. Alcohol Clin Exp Res 1993;17: 411417.Google Scholar
Warren, JT Jr,Peacock, ML, Rodriguez, LC, Fink, JK.An MspI polymorphism in the hyman serotonin receptor gene (HTR2). detection by DGGE and RFLP analysis. Hum Mol Genet 1993;2: 338.CrossRefGoogle ScholarPubMed
Gutierrez, B, Bertranpetit, J, Coller, Det al. Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder. Hum Genet 1997;100: 582584.Google ScholarPubMed
Kay, SR, Fiszbein, A, Opler, LR.The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13: 261276.CrossRefGoogle Scholar
Collier, AD, Arranz, JM, Li, T, Mupita, D, Brown, N, Treasure, J.Association between 5-HT2A gene promoter polymorphism and anorexia nervosa. Lancet 1997;350: 412.CrossRefGoogle ScholarPubMed
Enoch, MA, Goldman, D, Barnett, R, Sher, L, Mazzanti, CM, Rosenthal, NE.Association between seasonal affective disorder and the 5-HT2A promoter polymorphism-1438G/A. Mol Psychiatry 1999;4: 8992.CrossRefGoogle Scholar
Himei, A, Kono, Y, Yoneda, H, Sakai, T, Koh, J, Sakai, J, Inada, Y, Imamichi, H.An association study between alcoholism and the serotonergic receptor genes. Alcohol Clin Exp Res 2000;24: 341342.CrossRefGoogle ScholarPubMed
Inayama, Y, Yoneda, H, Sakai, T, Ishida, T, Nonomura, Y, Kono, Y, Takahata, R, Koh, J, Sakai, J, Takai, A, Inada, Y, Asaba, H.Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet 1996;67: 103105.3.0.CO;2-S>CrossRefGoogle Scholar
Ohara, K, Ino, A, Ishigaki, T, Tani, K, Tsukamoto, T, Nakamura, Y, Ohara, K.Analysis of the 5′-flanking promoter region of the 5-HT2A receptor gene in schizophrenia. Neuropsychopharmacology 1997;17: 274278.CrossRefGoogle Scholar
Ohara, K, Nagai, M, Tsukamoto, T, Tani, K, Suzuki, Y, Ohara, K.5-HT2A receptor gene promoter polymorphism – 1438G/A and mood disorders. Neuroreport 1998;9: 11391141.CrossRefGoogle ScholarPubMed
Shinkai, T, Ohmori, O, Kojima, H, Terao, T, Suzuki, T, Abe, K.Negative association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia in Japan. Hum Hered 1998;48: 212215.CrossRefGoogle ScholarPubMed
Kane, JM.Risperidone. new horizons for the schizophrenic patient. J Clin Psychiatry 1994;55: 5. Google ScholarPubMed
Arranz, M, Collier, D, Sodhi, Met al. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet 1995;29: 281282. CrossRefGoogle Scholar
Nimgaonkar, VL, Zhang, XR, Brar, JS, Deleo, M, Genguli, R.5HT2 receptor gene locus: association with schizophrenia or treatment response not detected. Psychiatr Genet 1996;6: 2327.CrossRefGoogle Scholar
Williams, J, Spurlock, G, McGuffin, Pet al. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. Lancet 1996;347: 12941296.CrossRefGoogle ScholarPubMed
Mita, T, Hanada, S, Nishino, Net al. Decreased serotonin S2 and increased dopamine D2 receptor in chronic schizophrenics. Biol Psychiatry 1986;21: 14071414.CrossRefGoogle ScholarPubMed
Laruelle, M, Abi-Dargham, A, Casanova, MF, Toti, R, Weinberger, DR, Kleinman, JE.Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study. Arc General Psychiatry 1993;50: 810818. CrossRefGoogle ScholarPubMed
Biegon, A, Weizman, A, Karp, L, Ram, A, Tiano, S, Wolff, M.Serotonin 5-HT2 receptor binding on blood platelets – a peripheral marker for depression? Life Sci 1987;41: 24852492.CrossRefGoogle Scholar
Kusumi, I, Koyama, T, Yamashita, I.Serotonin- stimulated Ca2+ response is increased in the blood platelets of depressed patients. Biol Psychiatry 1991;30: 310.CrossRefGoogle ScholarPubMed
Arango, V, Ernsberger, P, Marzuk, PMet al. Autoradiographic demonstration of increased serotonin 5-HT2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch General Psychiatry 1997;47: 10381047. CrossRefGoogle ScholarPubMed
Crow, TJ.Molecular pathology of schizophrenia more than one disease process. Br Medical J 1980;I: 6668. CrossRefGoogle Scholar
Andreasen, NC.Negative symptoms in schizophrenia definition and reliability. Arch General Psychiatry 1982;39: 784788. CrossRefGoogle ScholarPubMed