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Obesity is associated with previous suicide attempts in bipolar disorder

Published online by Cambridge University Press:  24 June 2014

Fabiano A. Gomes ,
Márcia Kauer-Sant’Anna ,
Pedro V. Magalhães ,
Felice N. Jacka ,
Seetal Dodd ,
Clarissa S. Gama ,
Ângelo Cunha ,
Michael Berk  and
Flávio Kapczinski
Fabiano A. Gomes
Affiliation:
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Márcia Kauer-Sant’Anna
Affiliation:
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Pedro V. Magalhães
Affiliation:
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Felice N. Jacka
Affiliation:
Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Australia
Seetal Dodd
Affiliation:
Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Australia
Clarissa S. Gama
Affiliation:
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Ângelo Cunha
Affiliation:
University Hospital, Universidade Federal de Santa Maria, Santa Maria, Brazil
Michael Berk
Affiliation:
Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Australia
Flávio Kapczinski*
Affiliation:
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
*
Professor Flávio Kapczinski, INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, 2350 CEP 90035-003, Porto Alegre, RS, Brazil. Tel: +55 51 21018845; Fax: +55 51 21018846; E-mail: [email protected]
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Abstract

Gomes FA, Kauer-Sant’Anna M, Magalhães PV, Jacka FN, Dodd S, Gama CS, Cunha Â, Berk M, Kapczinski F. Obesity is associated with previous suicide attempts in bipolar disorder.

Objective:

There is a paucity of data about risk factors for suicide attempts in bipolar disorder. The aim of this study is to examine the association between suicide attempts and obesity in people with bipolar disorder.

Methods:

Two hundred fifty-five DSM-IV out-patients with bipolar disorder were consecutively recruited from the Bipolar Disorder Program at Hospital das Clínicas de Porto Alegre and the University Hospital at the Universidade Federal de Santa Maria, Brazil. Diagnosis and clinical variables were assessed with Structured Clinical Interview for DSM-IV-axis I (SCID I) and Program structured protocol. History of suicide attempts was obtained from multiple information sources including patients, relatives and review of medical records. Patients with body mass index (BMI) ≥ 30 were classified as obese.

Results:

Over 30% of the sample was obese and over 50% had a history of suicide attempt. In the multivariate model, obese patients were nearly twice (OR = 1.97, 95% CI: 1.06–3.69, p = 0.03) as likely to have a history of suicide attempt(s).

Conclusion:

Our results emphasise the relevance of obesity as an associated factor of suicide attempts in bipolar disorder. Obesity may be seen as correlate of severity and as such, must be considered in the comprehensive management of bipolar patients.

Keywords

bipolar disorderobesitysuicide
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 22 , Issue 2 , April 2010 , pp. 63 - 67
Copyright
Copyright © 2010 John Wiley & Sons A/S

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References

Kupfer, DJ.The increasing medical burden in bipolar disorder. JAMA 2005;293:2528–2530. CrossRefGoogle ScholarPubMed
Angst, F, Stassen, HH, Clayton, PJ, Angst, J.Mortality of patients with mood disorders: follow-up over 34–38 years. J Affect Disord 2002;68:167–181. CrossRefGoogle ScholarPubMed
Roshanaei-Moghaddam, B, Katon, W.Premature mortality from general medical illnesses among persons with bipolar disorder: a review. Psychiatr Serv 2009;60:147–156. CrossRefGoogle ScholarPubMed
IOFT – International Obesity Task Force. Global prevalence of adult obesity. International Obesity Task Force Prevalence Data, 2009 Available from: http://www.iotf.org/database/documents/GlobalPrevalenceofAdultObesityJanuary2009v2.pdf (accessed 23 January 2009).Google Scholar
Wildes, JE, Marcus, MD, Fagiolini, A.Obesity in patients with bipolar disorder: a biopsychosocial-behavioral model. J Clin Psychiatry 2006;67:904–915. CrossRefGoogle ScholarPubMed
Elmslie, JL, Silverstone, JT, Mann, JI, Williams, SM, Romans, SE.Prevalence of overweight and obesity in bipolar patients. J Clin Psychiatry 2000;61:179–184. CrossRefGoogle ScholarPubMed
McElroy, SL, Frye, MA, Suppes, Tet al. Correlates of overweight and obesity in 644 patients with bipolar disorder. J Clin Psychiatry 2002;63:207–213. CrossRefGoogle ScholarPubMed
Fagiolini, A, Kupfer, DJ, Houck, PR, Novick, DM, Frank, E.Obesity as a correlate of outcome in patients with bipolar I disorder. Am J Psychiatry 2003;160:112–117. CrossRefGoogle ScholarPubMed
Taylor, V, Macdonald, K, McKinnon, MC, Joffe, RT, MacQueen, GM.Increased rates of obesity in first-presentation adults with mood disorders over the course of four-year follow-up. J Affect Disord 2008;109:127–131. CrossRefGoogle ScholarPubMed
Maina, G, Salvi, V, Vitalucci, A, D’Ambrosio, V, Bogetto, F.Prevalence and correlates of overweight in drug-naïve patients with bipolar disorder. J Affect Disord 2008;110:149–155. CrossRefGoogle ScholarPubMed
Fagiolini, A, Frank, E, Houck, PRet al. Prevalence of obesity and weight change during treatment in patients with bipolar I disorder. J Clin Psychiatry 2002;63:528–533. CrossRefGoogle ScholarPubMed
Fagiolini, A, Kupfer, DJ, Rucci, P, Scott, JA, Novick, DM, Frank, E.Suicide attempts and ideation in patients with bipolar I disorder. J Clin Psychiatry 2004;65:509–514. CrossRefGoogle ScholarPubMed
Fagiolini, A, Frank, E, Scott, JA, Turkin, S, Kupfer, DJ.Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians. Bipolar Disord 2005;7:424–430. CrossRefGoogle ScholarPubMed
Wang, PW, Sachs, GS, Zarate, CAet al. Overweight and obesity in bipolar disorders. J Psychiatr Res 2006;40:762–764. CrossRefGoogle ScholarPubMed
McElroy, SL, Kotwal, R, Malhotra, S, Nelson, EB, Keck, PE, Nemeroff, CB.Are mood disorders and obesity related? A review for the mental health professional. J Clin Psychiatry 2004;65:634–651. CrossRefGoogle ScholarPubMed
Carpenter, KM, Hasin, DS, Allison, DB, Faith, MS.Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: results from a general population study. Am J Public Health 2000;90:251–257. Google ScholarPubMed
Mather, AA, Cox, BJ, Enns, MW, Sareen, J.Associations of obesity with psychiatric disorders and suicidal behaviors in a nationally representative sample. J Psychosom Res 2009;66:277–285. CrossRefGoogle Scholar
McIntyre, RS, Muzina, DJ, Kemp, DEet al. Bipolar disorder and suicide: research synthesis and clinical translation. Curr Psychiatry Rep 2008;10:66–72. CrossRefGoogle ScholarPubMed
Hawton, K, Sutton, L, Haw, C, Sinclair, J, Harriss, L.Suicide and attempted suicide in bipolar disorder: a systematic review of risk factors. J Clin Psychiatry 2005;66:693–704. CrossRefGoogle ScholarPubMed
Gazalle, FK, Andreazza, AC, Ceresér, KM, Hallal, PC, Santin, A, Kapczinski, F.Clinical impact of late diagnose of bipolar disorder. J Affect Disord 2005;86:313–316. CrossRefGoogle ScholarPubMed
Fleck, MP, Bourdel, MC.Method of simulation and choice of factors in the analysis of principal components (Portuguese). Rev Saude Publica 1998;32:267–272. CrossRefGoogle Scholar
Vilela, JA, Crippa, JA, Del-Ben, CM, Loureiro, SR.Reliability and validity of a Portuguese version of the Young Mania Rating Scale. Braz J Med Biol Res 2005;38:1429–1439. CrossRefGoogle ScholarPubMed
Asberg, M, Träskman, L, Thorén, P.5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 1976;33:1193–1197. CrossRefGoogle ScholarPubMed
World Health Organization. Obesity: preventing and managing the global epidemic. Publication WHO/NUT/NCS/98.1. Geneva, Switzerland: World Health Organization; 1997. Google ScholarPubMed
Berkowitz, RI, Fabricatore, AN.Obesity, psychiatric status, and psychiatric medications. Psychiatr Clin North Am 2005;28:39–54, vii–viii. CrossRefGoogle ScholarPubMed
Cardoso, BM, Kauer Sant’Anna, M, Dias, VV, Andreazza, AC, Ceresér, KM, Kapczinski, F.The impact of co-morbid alcohol use disorder in bipolar patients. Alcohol 2008;42:451–457. CrossRefGoogle ScholarPubMed
Rosa, AR, Andreazza, AC, Kunz, Met al. Predominant polarity in bipolar disorder: diagnostic implications. J Affect Disord 2008;107:45–51. CrossRefGoogle ScholarPubMed
Grunebaum, MF, Ramsay, SR, Galfalvy, HCet al. Correlates of suicide attempt history in bipolar disorder: a stress-diathesis perspective. Bipolar Disord 2006;8:551–557. CrossRefGoogle ScholarPubMed
Sánchez-Gistau, V, Colom, F, Mané, A, Romero, S, Sugranyes, G, Vieta, E.Atypical depression is associated with suicide attempt in bipolar disorder. Acta Psychiatr Scand 2009; 120:30–36. CrossRefGoogle ScholarPubMed
Rosa, AR, Franco, C, Martínez-Aran, Aet al. Functional impairment and previous suicide attempts in bipolar disorder. Acta Neuropsychiatrica 2008;20:300–306. CrossRefGoogle ScholarPubMed
Simon, GE, Hunkeler, E, Fireman, B, Lee, JY, Savarino, J.Risk of suicide attempt and suicide death in patients treated for bipolar disorder. Bipolar Disord 2007;9:526–530. CrossRefGoogle ScholarPubMed
Neves, FS, Malloy-Diniz, LF, Corrêa, H.Suicidal behavior in bipolar disorder: what is the influence of psychiatric comorbidities? J Clin Psychiatry 2009;70:13–18. CrossRefGoogle ScholarPubMed
Post, RM.The impact of bipolar depression. J Clin Psychiatry 2005;66(Suppl. 5):5–10. Google ScholarPubMed
Berk, M, Malhi, GS, Mitchell, PBet al. Scale matters: the need for a bipolar depression rating scale (BDRS). Acta Psychiatr Scand 2004;110:1–8. CrossRefGoogle Scholar
Colom, F, Vieta, E, Daban, C, Pacchiarotti, I, Sánchez-Moreno, J.Clinical and therapeutic implications of predominant polarity in bipolar disorder. J Affect Disord 2006;93:13–17. CrossRefGoogle ScholarPubMed
Pasco, J, Jacka, F, Williams, LJet al. Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study. J Affect Disord 2007;107:211–225. Google ScholarPubMed
McIntyre, RS, Soczynska, JK, Konarski, JZet al. Should depressive syndromes be reclassified as “metabolic syndrome type II”? Ann Clin Psychiatry 2007;19:257–264. CrossRefGoogle ScholarPubMed
McEwen, BS.Mood disorders and allostatic load. Biol Psychiatry 2003;54:200–207. CrossRefGoogle ScholarPubMed
Kapczinski, F, Vieta, E, Andreazza, ACet al. Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neurosci Biobehav Rev 2008;32:675–692. CrossRefGoogle ScholarPubMed