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Gene expression in peripheral blood in treatment-free major depression

Published online by Cambridge University Press:  10 February 2020

Alfredo B. Cuellar-Barboza ,
Jorge A. Sánchez-Ruiz Open the ORCID record for Jorge A. Sánchez-Ruiz [Opens in a new window] ,
Iram P. Rodriguez-Sanchez ,
Sarai González ,
Geovana Calvo ,
José Lugo ,
Antonio Costilla-Esquivel ,
Laura E. Martínez  and
Marisol Ibarra-Ramirez
Alfredo B. Cuellar-Barboza*
Affiliation:
Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
Jorge A. Sánchez-Ruiz
Affiliation:
Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
Iram P. Rodriguez-Sanchez
Affiliation:
Molecular and Structural Physiology Laboratory, School of Biological Sciences, Universidad Autónoma de Nuevo León, Monterrey, México
Sarai González
Affiliation:
Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
Geovana Calvo
Affiliation:
Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
José Lugo
Affiliation:
Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
Antonio Costilla-Esquivel
Affiliation:
Department of Psychiatry, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México Centro de Investigación en Matemáticas A.C. (CIMAT), Monterrey, México
Laura E. Martínez
Affiliation:
Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
Marisol Ibarra-Ramirez
Affiliation:
Department of Genetics, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
*
Author for correspondence: Alfredo B. Cuellar-Barboza, Email: [email protected]
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Abstract

Background:

Peripheral gene expression of several molecular pathways has been studied in major depressive disorder (MDD) with promising results. We sought to investigate some of these genes in a treatment-free Latino sample of Mexican descent.

Material and Methods:

The sample consisted of 50 MDD treatment-free cases and 50 sex and age-matched controls. Gene expression of candidate genes of neuroplasticity (BDNF, p11, and VGF), inflammation (IL1A, IL1B, IL4, IL6, IL7, IL8, IL10, MIF, and TNFA), the canonical Wnt signaling pathway (TCF7L2, APC, and GSK3B), and mTOR, was compared in cases and controls. RNA was obtained from blood samples. We used bivariate analyses to compare subjects versus control mean mRNA quantification of target genes and lineal regression modelling to test for effects of age and body mass index on gene expression.

Results:

Most subjects were female (66%) with a mean age of 26.7 (SD 7.9) years. Only GSK3B was differentially expressed between cases and controls at a statistically significant level (p = 0.048). TCF7L-2 showed the highest number of correlations with MDD-related traits, yet these were modest in size.

Discussion:

GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression, and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry.

Keywords

gene expressiondepressive disorderglycogen synthase kinase 3 betatranscription factor 7-like 2 proteinWnt signaling pathway
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 32 , Issue 3 , June 2020 , pp. 135 - 144
Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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