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Event-related potentials and white matter lesions in bipolar disorder

Published online by Cambridge University Press:  24 June 2014

E. F. P. M. Vuurman ,
A. Honig ,
T. H. Lamers ,
J. Wiersma ,
L. Krabbendam ,
P. A. M. Hofman ,
W. A. Nolen  and
J. Jolles
E. F. P. M. Vuurman*
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
A. Honig
Affiliation:
Academisch Ziekenhuis Maastricht, Department of Psychiatry
T. H. Lamers
Affiliation:
Academisch Ziekenhuis Maastricht, Department of Psychiatry
J. Wiersma
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
L. Krabbendam
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
P. A. M. Hofman
Affiliation:
Academisch Ziekenhuis Maastricht, Department of Radiology
W. A. Nolen
Affiliation:
Academisch Ziekenhuis Utrecht, Department of Psychiatry
J. Jolles
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
*
EFPM Vuurman, Institute of Brain and Behavior, University of Maastricht, Postbus 616, 6200 MD Maastricht, the Netherlands. Tel: +31 433881046; Fax: +31 433884092; E-mail: [email protected]
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Abstract

Objectives:

To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls.

Methods:

Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory ‘oddball’ task, and the amplitude of the resulting P300 wave was compared.

Results:

Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group.

Conclusion:

Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.

Keywords

bipolar disorderP300white matter lesions
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 14 , Issue 1 , February 2002 , pp. 11 - 16
Copyright
Copyright © Acta Neuropsychiatrica 2002 

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References

Rangel-Guerra, RA, Perez-Payan, H, Minkhoff, C, Todd, LE.Nuclear magnetic resonance imaging in bipolar affective disorder. Am J Neuradiol 1983;4:229–231. Google Scholar
Dolan, RJ, Calloway, SP, Thacker, PF, Mann, AH.The cerebral cortical appearance in depressed patients. Psychol Med 1986;16:775–779.CrossRefGoogle Scholar
Austin, MP, Mitchel, P.The anatomy of melancholia. Does frontal subcortical pathophysiology underpin its psychomotor and cognitive manifestations? Psychol Med 1995;25:665–672.CrossRefGoogle ScholarPubMed
Cummings, JL.The neuroanatomy of depression. J Clin Psychiatry 1993;54:14–20.Google Scholar
Calloway, S, Cummings, J.Subcortical disease and neuropsychiatric illness. J Neuropsychiatr Clin Neurosci 1994;6:93–99. Google Scholar
Nasrallah, HA, Coffman, JA, Olson, SC.Structural brain imaging findings in affective disorders: an overview. J Neuropsychiatry 1989;1:21–26. Google ScholarPubMed
Dupont, RM, Jernigan, TL, Buthers, Net al. Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Arch Gen Psychiatry 1990;47:55–59.CrossRefGoogle ScholarPubMed
Coffey, CE, Fiegel, GS, Djang, WTet al. White matter hyperintensities and magnetic resonance imaging: clinical and neuroanatomical correlates in the depressed elderly. J Neuropsychiatr Clin Neurosci 1989;1:135–144. Google Scholar
Buchsbaum, M, Landau, S, Murphy, Pet al. Averaged evoked response in bipolar and unipolar disorders; relationships to sex, age of onset and monoamine oxidase. Biol Psychiatry 1973;7:199–211.Google Scholar
Thier, P, Axman, D, Giedri, H.Slow potentials and psychomotor retardation in depression. Electroencep Clin Neurophysiol 1986;63:570–581. CrossRefGoogle ScholarPubMed
Blackwood, DHR, Whalley, LJ, Christie, JEet al. Changes in auditory P300 event related potentials in schizophrenia and depression. Br J Psychiatry 1987;150:154–160.CrossRefGoogle Scholar
Muir, WJ, St Clair, DM, Blackwood, DHR.Long latency auditory event related potentials in schizophrenia and in bipolar and unipolar disorder. Psychol Med 1991, 21867–21879. Google Scholar
Souza, VBN, Muir, WJ, Walker, MTet al. Auditory P300 event related potentials and neuropsychological performance in schizophrenia and bipolar affective disorder. Biol Psychiatry 1995;37:300–310.CrossRefGoogle ScholarPubMed
Cassano, GB, Akiskal, HS, Musetti, Let al. Psychopathology, temperament and past course in primary major depression. Towards a redefinition of bipolarity with a new semistructured interview for depression. Psychopathology 1989;22:278–288.CrossRefGoogle Scholar
Simpson, SG, Folstein, SE, Meyers, DAet al. Bipolar II, the most common phenotype? Am J Psychiatry 1993;150:901–903.Google Scholar
Coryell, W, Endicott, J, Reich, T, Andeassen, Net al. A family study of bipolar II disorder. Br J Psychiatry 1984;145:49–54.CrossRefGoogle ScholarPubMed
Kato, T, Takahashi, S, Shiori, Tet al. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 MRS. J Affect Disord 1994. Google Scholar
Cassano, GB, Akiskal, HS, Savino, Met al. Proposed subtypes of bipolar II and related disorders with hypomanic episodes (or cyclothymia) and with hyperthymic temperament. J Affect Disord 1992;26:127–140.CrossRefGoogle ScholarPubMed
Akiskal, HS.Dysthymic and cyclothymic depressions: therapeutic considerations. J Clin Psychiatry 1994;55:46–52.Google ScholarPubMed
Havermans, R, Honig, A, Vuurman, EFPMet al. A controlled study of temporal lobe structure volumes and P300 responses in schizophrenic patients with persistent auditory hallucinations. Schizophr Res 1999;38:151–158.CrossRefGoogle ScholarPubMed
World Health Organization (WHO). Composite international diagnostic interview (CIDI), version 1.1. Geneva: WHO, 1993. Google Scholar
First, MB, Spitzer, RL, Williams, JBW, Gibbon, M.Structured clinical interview for DSM-IV (SCID). Washington DC: American Psychiatric Association, 1997. Google Scholar
Achten, E, De Leeuw, FE, De Groot, JC, Heijboer, R, Breteler, M, Oudkerk, M. A new and extensive rating scale for the aging brain: quality control and inter and intrarater variability: the Rotterdam Scan Study. Sydney: ISMRM, 1998. Google Scholar
Soares, J, Mann, JJ.The anatomy of mood disorders: a review of structural neuroimaging studies. Biol Psychiatry 1997;41:86–106.CrossRefGoogle ScholarPubMed
Videbech, P.MRI findings in patients with affective disorders: a meta analysis. Acta Psychiatr Scand 1997;96:157–168.CrossRefGoogle ScholarPubMed
Hofman, PA, Kemerink, GJ, Jolles, J, Wilmink, JT . Quantitative analysis of magnetization transfer images of the brain: effect of closed head injury, age and sex on white matter. Magn Reson Med 1999;42:803–806.DOI: 10.1002/(sici)1522-2594(199910)42:4<803::aid-mrm24>3.0.co;2-f3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Yanai, I, Fujikawa, T, Osada, M, Yamawaki, S, Touhouda, Y.Changes in auditory P300 in patients wiith major depression and silent cerebral infarction. J Affect Disord 1997;46:263–271.CrossRefGoogle Scholar
O'Donnel, BF, Faux, SF, McCarley, RWet al. Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process. Arch Gen Psychiatry 1995;52:544–549.CrossRefGoogle Scholar
McCarley, RW, Shenton, ME, O'Donnnel, BFet al. Auditory P300 abnormalities and left posterior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry 1993;50:190–197.CrossRefGoogle Scholar
McGuire, PK, Frith, CD.Disordered functional connectivity in schizophrenia. Psychol Med 1996;26:663–667.CrossRefGoogle Scholar
Krabbendam, L, Honig, A, Wiersma, Jet al. Cognitive dysfunctions and white matter lesions in patients with bipolar disorders in remission. Acta Psychiatr Scand 2000;101:274–280.DOI: 10.1034/j.1600-0447.2000.101004274.xGoogle ScholarPubMed