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Dysregulation of ion fluxes in bipolar affective disorder

Published online by Cambridge University Press:  18 September 2015

H.C.R. Grunze ,
J. Langosch ,
C. Normann ,
D. Rujescu ,
B. Amann  and
J. Waiden
H.C.R. Grunze*
Affiliation:
Department of Psychiatry, LMU München, Germany
J. Langosch
Affiliation:
Department of Psychiatry, University of Freiburg, Freiburg, Germany
C. Normann
Affiliation:
Department of Psychiatry, University of Freiburg, Freiburg, Germany
D. Rujescu
Affiliation:
Department of Psychiatry, LMU München, Germany
B. Amann
Affiliation:
Department of Psychiatry, LMU München, Germany
J. Waiden
Affiliation:
Department of Psychiatry, University of Freiburg, Freiburg, Germany
*
Psychiatrische Klinik der LMU München, Nussbaumstr. 7, 80336 München, GermanyTel 01149-89-51605330, Fax 01149-89-51605330
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Abstract

Bipolar disorder has attracted numerous research from different neurobiological angles. This review will summarize selected findings focusing on the role of disturbed transmem-braneous ion fluxes. Several mood stabilizers exhibit a distinct profile including effects on sodium, calcium and potassium conductance. In summary, some decisive mechanisms of action as calcium antagonism and modulation of potassium currents may play a crucial role in the success of any given mood stabilizer in bipolar disorder.

Keywords

bipolar disordersodiumcalciumpotassiummood stabilizer
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 81 - 85
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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