Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-18T20:24:07.756Z Has data issue: false hasContentIssue false
  • English
  • Français

Disturbed cognitive functioning and clinical symptoms: two independent problem areas in schizophrenia

Published online by Cambridge University Press:  24 June 2014

G. H. M. Pijnenborg ,
M. van Beilen ,
J. Arends ,
E. A. E. Holthausen  and
F. K. Withaar
G. H. M. Pijnenborg*
Affiliation:
Department of Psychotic Disorders, GGZ-Drenthe, Assen School for Behavioral and Cognitive Neurosciences (BCN), University of Groningen, Groningen, the Netherlands
M. van Beilen
Affiliation:
Department of Psychotic Disorders, GGZ-Drenthe, Assen School for Behavioral and Cognitive Neurosciences (BCN), University of Groningen, Groningen, the Netherlands
J. Arends
Affiliation:
Department of Psychotic Disorders, GGZ-Drenthe, Assen
E. A. E. Holthausen
Affiliation:
Department of Psychiatry, University of Groningen, Groningen, the Netherlands
F. K. Withaar
Affiliation:
Department of Psychotic Disorders, GGZ-Drenthe, Assen
*
Department of Psychotic Disorders, GGZ-Drenthe, Dennenweg 9, Postbus 30007, 9400 RA Assen, the Netherlands. Tel. 0592334911; Fax: 000-0000-0000; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Research findings on the relationship between cognitive functioning and psychiatric symptoms in schizophrenia have yielded inconsistent results. Although several models were postulated linking cognition and symptoms, the most recent studies point in the direction of cognition and symptoms being relatively independent disease processes.

Objective:

The hypothesis that cognitive decline and psychiatric symptoms are independent disease processes was tested.

Methods:

The relationship between cognitive functioning and clinical symptoms was examined in a large sample of 100 schizophrenia patients.

Results:

The hypothesis was largely confirmed.

Conclusion:

No convincing evidence was found that symptoms and cognition were related.

Keywords

cognitive functioningschizophreniasymptoms
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 5 , October 2003 , pp. 280 - 283
Copyright
Copyright © 2003 Blackwell Munksgaard

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Liddle, PF. Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychological-Medicine, 1987;17: 49–57.CrossRefGoogle ScholarPubMed
Lindenmayer, JP, Bernstein-Hyman, R, Grochowski, S. Five Factor Model of Schizophrenia. J Nerv Mental Dis 1994;182: 631–638. CrossRefGoogle ScholarPubMed
Heinrichs, R W, Zakzanis, KK. Neurocognitive deficit in schizophrenia: a quantative review of the evidence. Neuropsychology 1998;12: 426–445.CrossRefGoogle Scholar
Aleman, A, Hijman, R, De Haan, EHF, Kahn, RS. Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry 1999;156: 1358–1366.Google ScholarPubMed
Braff, DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Bull 1993; 19: 233–259.CrossRefGoogle Scholar
Johnson-Selfridge, M, Zalewski, C. Moderator variables of executive functioning in schizophrenia: Meta-analytic findings. Schizophr Bull 2001;27: 305–316.CrossRefGoogle ScholarPubMed
Frith, CD. The Cognitive Neuropsychology of Schizophrenia. Hillsdale, NJ: Lawrence Erlbaum Association, 1992. Google ScholarPubMed
Nieuwenstein, MR, Aleman, A, De Haan, EHF. Relationship between symptom dimensions and neurocognitive functioning in schizophrenia: a meta-analysis of WCST and CPT studies. J Psychiatr Res 2001;35: 119–125.CrossRefGoogle ScholarPubMed
Cuesta, MJ, Peralta, V. Cognitive disorders in the positive, negative, and disorgazation syndromes of schizophrenia. Psychiatr Res 1995;58: 227–235. CrossRefGoogle ScholarPubMed
O'Leary, DS, Flaum, M, Kesler, ML, Flashman, LA, Arndt, S, Andreassen, NC. Cognitive correlates of the negative, disorganised and psychotic symptom dimensions of schizophrenia. J Neuropsychiatr Clin Neurosci 2000; 12: 4–15. CrossRefGoogle Scholar
Verdoux, H, Liraud, F, Bourgeois, MLet al. The association of neuropsychological deficits to clinical symptoms in first-admission subjects with psychotic disorders. Schizophr Res 1999; 37: 198–201. Google Scholar
Mahurin, RK, Velligan, DI, Miller, AL. Executive-frontal lobe cognitive dysfunction in schizophrenia: A symptom subtype analysis. Psychiatr Res 1998;79: 139–149. CrossRefGoogle ScholarPubMed
Basso, MR, Nasrallah, HA, Olson, SC, Bornstein, RA. Neuropsychological correlates of negative, disorganized and psychotic symptoms in schizophrenia. Schizophr Res 1998; 31: 99–111.CrossRefGoogle Scholar
Suslow, T, Junghanns, K, Weitzsch, C, Arolt, V. Relations between neuropsychological vulnerability markers and negative symptoms in schizophrenia. Psychopathology 1998;31: 178–187.CrossRefGoogle Scholar
Collins, AA, Remington, GJ, Coulter, K, Birkett, K. Insight, neurocognitive function and symptom clusters in chronic schizophrenia. Schizophr Res 1997;27: 37–44.CrossRefGoogle ScholarPubMed
Holthausen, AE, Wiersma, D, Knegtering, RH, Van den Bosch, RJ. Psychopathology and cognition in schizophrenia spectrum disorders: the role of depressive symptoms. Schizophr Res 1999;39: 65–71.CrossRefGoogle ScholarPubMed
Brebion, G, Gorman, JM, Malaspina, D, Sharif, Z, Amador, X. Clinical and cognitive factors associated with verbal memory task performance in patients with schizophrenia. Am J Psychiatry 2001;158: 758–764CrossRefGoogle ScholarPubMed
Green, MF, Nuechterlein, KH. Should schizophrenia be treated as a neurocognitive disorder? Schizophr Bull 1999;25: 309–318CrossRefGoogle ScholarPubMed
Kay, SR, Fishbein, A, Opler, LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987;13: 261–276.CrossRefGoogle Scholar
Saan, RJ, Deelman, BG. De 15-WoordenTests A (manual) (intern publication). Groningen: Afdeling Neuropsychologie AZG, 1986. Google Scholar
Van den Bosch, RJ, Rombouts, RP, Asma, MJ. What determines continuous performance task performance? Schizophr Bull 1996;22: 643–651.CrossRefGoogle ScholarPubMed
Reitan, RM. Manual of Administration of Neuropsychological Testbatteries for Adults and Children. Tucson, AZ: Neuropsychological Laboratory, 1979. Google Scholar
Heaton, RK. Wisconsin Card Sorting Test Manual. Odessa: Psychological Assessment Resources, 1981. Google Scholar
Andreasen, NC. The Scale for Assessment of Positive and Negative Symptoms. Iowa City, IA: University of Iowa, 1982. Google Scholar