Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-25T11:32:21.188Z Has data issue: false hasContentIssue false
  • English
  • Français

Differential BOLD responses to auditory target stimuli associated with a skin conductance response

Published online by Cambridge University Press:  24 June 2014

Jim Lagopoulos ,
Evian Gordon  and
Philip B. Ward
Jim Lagopoulos*
Affiliation:
School of Psychiatry, University of NSW, Sydney, Australia Mayne Clinical Research Imaging Centre, Randwick, Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Sydney, Australia
Evian Gordon
Affiliation:
Brain Dynamics Centre, Westmead Hospital, NSW, Australia Department of Psychological Medicine, The University of Sydney, NSW, Australia
Philip B. Ward
Affiliation:
School of Psychiatry, University of NSW, Sydney, Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Sydney, Australia
*
Dr Jim Lagopoulos, Mayne Clinical Research Imaging Centre, Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia.Tel: +61 2 93822998; Fax: +61 2 93828208; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

The orienting reflex (OR) is a fundamental biological mechanism thought to reflect automatic adaptive processing of environmental stimuli necessary for successful interaction with the environment. It has been hypothesized that the OR is generated in response to novelty such as in the case where a mismatch results between an internal neuronal template stored in working memory and incoming stimuli. Recent blood oxygenated level dependant (BOLD) activation studies that have investigated networks involved in the processing of novelty have suggested the recruitment of a distributed limbic-neocortical network. In the present study, event-related functional resonance imaging with simultaneous autonomic electrodermal activity was used to detect single trials of an auditory oddball task associated with the OR.

Results:

The pattern of activations indicated two distinct, but partially overlapping, networks. Predominantly, frontal activations were seen for the target stimuli that did elicit an OR, including the orbitofrontal gyrus and anterior cingulate gyrus, as well as activations in the anterior thalamus and cerebellum. On contrary, parietal activations including the supramarginal gyrus and precuneus were seen for the target stimuli that that did not elicit an OR.

Keywords

fMRISCRorienting reflexoddballtarget detection
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 2 , April 2006 , pp. 105 - 114
Copyright
Copyright © 2006 Blackwell Munksgaard

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Pavlov, IP.Conditioned reflexes: an investigation of the physiological activity of the cerebral cortex. Oxford: Oxford University and Press Humphrey Milford, 1927. Google Scholar
Sokolov, EN.Perception and the conditioned reflex. New York: Pergamon, 1963. Google Scholar
Sokolov, EN.The neuronal mechanisms of the orienting reflex. New Jersey: Hillsdale, 1975. Google Scholar
Williams, LM, Brammer, MJ, Skerrett, Det al. The neural correlates of orienting: an integration of fMRI and skin conductance orienting. Neuroreport 2000;11: 3011–3015. CrossRefGoogle ScholarPubMed
Williams, LM, Phillips, ML, Brammer, MJet al. Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage 2001;14: 1070–1079. CrossRefGoogle ScholarPubMed
Bahramali, H, Gordon, E, Lim, CLet al. Evoked related potentials associated with and without an orienting reflex. Neuroreport 1997;8: 2665–2669. CrossRefGoogle ScholarPubMed
Lagopoulos, J, Gordon, E, Barhamali, Het al. Dysfunctions of automatic (P300a) and controlled (P300b) processing in Parkinson's disease. Neurol Res 1998;20: 5–10. CrossRefGoogle ScholarPubMed
Squires, NK, Squires, KC, Hillyard, SA.Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 1975;38: 387–401. CrossRefGoogle ScholarPubMed
Shiffrin, RM, Schneider, W.Controlled and automatic human information processing: II. Psychol Rev 1977;84: 127–190. CrossRefGoogle Scholar
Schneider, W, Shiffrin, RM.Controlled and automatic human information processing: I. detection, search and attention. Psychol Rev 1977;84: 1–66. CrossRefGoogle Scholar
Hillyard, SA, Courchesne, E, Krausz, HI, Picton, TW. (1976) Scalp topography of the P3 wave in different auditory tasks. In: McCallum, WC, ed. Responsive brain: proceedings of the Third International Congress on event-related slow potentials of the brain, pp. 49–68. Bristol: John Wright and Sons Ltd. Google Scholar
Snyder, E, Hillyard, SA.Long-latency evoked potentials to irrelevant, deviant stimuli. Behav Biol 1976;16: 319–331. CrossRefGoogle ScholarPubMed
Polich, J, Howard, L, Starr, A.Effects of age on the P300 component of the event-related potential from auditory stimuli: peak definition, variation and measurement. J Gerontol 1985;40: 721–726. CrossRefGoogle ScholarPubMed
Knight, RT.Aging decreases auditory event-related potentials to unexpected stimuli in humans. Psychol Aging 1987;8: 109–113. Google ScholarPubMed
Tachibana, H, Toda, K, Sugita, M.Actively and passively evoked P3 latency of event-related potentials in Parkinson's Disease. J Neurol Sci 1992;111: 134–142. CrossRefGoogle ScholarPubMed
Schroger, E, Giard, MH, Wolff, C.Auditory distraction: event-related potential and behavioral indices. Clin Neurophysiol 2000;111: 1450–1460. CrossRefGoogle ScholarPubMed
Knight, RT.Contribution of human hippocampal region to novelty detection. Nature 1996;383: 256–259. CrossRefGoogle ScholarPubMed
Knight, RT, Hillyard, SA, Woods, DL, Neville, HJ.The effects of frontal cortex lesions on event-related potentials during auditory selective attention. Electroencephalogr Clin Neurophysiol 1981;52: 571–582. CrossRefGoogle ScholarPubMed
Lyytinen, H, Blomberg, AP, Naatanen, R.Event-related potentials and autonomic responses to a change in unattended auditory stimuli. Psychophysiology 1992;29: 523–534. CrossRefGoogle ScholarPubMed
Boucsein, W.Electrodermal activity. New York: Plenum Press, 1992. CrossRefGoogle Scholar
Lagopoulos, J, Malhi, GS, Shnier, RS.A system for recording artifact-free skin conductance responses in the MRI scanner. Behavioral research methods, instruments and computers 2005;37 (4): 657–664. CrossRefGoogle Scholar
Barry, RJ, Sokolov, EN.Habituation of phasic and tonic components of the orienting reflex. Int J Psychophysiol 1993;15: 30–42. CrossRefGoogle ScholarPubMed
Talaraich, J, Tournoux, P.Co-planar stereotactic atlas of the human brain. Stuttgart: Thieme, 1988. Google Scholar
Woods, RP, Cherry, SR, Mazziotta, JC.Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 1992;16: 620–633. CrossRefGoogle ScholarPubMed
Bosch, V.Statistical analysis of multi-subject fMRI data: assessment of focal activations. J Magn Reson Imaging 2000;11: 61–64. 3.0.CO;2-C>CrossRefGoogle Scholar
Menon, V, Ford, JM, Lim, KO, Glover, GH, Pfefferbaum, A.Combined event-related fMRI and EEG evidence for temporal-parietal cortex activation during target detection. Neuroreport 1997;8: 3029–3037. CrossRefGoogle ScholarPubMed
Yoshiura, T, Zhong, J, Shibata, DK, Kwok, WE, Shrier, DA, Numaguchi, Y.Functional MRI study of auditory and visual oddball tasks. Neuroreport 1999;10: 1683–1688. CrossRefGoogle ScholarPubMed
Linden, DE, Prvulovic, D, Formisano, Eet al. The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks. Cereb Cortex 1999;9: 815–823. CrossRefGoogle ScholarPubMed
McCarthy, G, Luby, M, Gore, J, Goldman, R.Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. J Neurophysiol 1997;77: 1630–1634. CrossRefGoogle ScholarPubMed
Opitz, B, Mecklinger, A, Friederici, AD, Von Cramon, DY.The functional neuroanatomy of novelty processing: integrating ERP and fMRI results. Cereb Cortex 1999a;9: 379–391. CrossRefGoogle ScholarPubMed
Devinsky, O, Morrell, MJ, Vogt, BA.Contributions of anterior cingulate cortex to behaviour. Brain 1995;118 (Pt. 1):279–306. CrossRefGoogle ScholarPubMed
Knight, RT, Scabini, D, Woods, DL, Clayworth, CC.Contributions of temporal-parietal junction to the human auditory P3. Brain Res 1989;502: 109–116. CrossRefGoogle Scholar
Kiehl, KA, Laurens, KR, Duty, TL, Forster, BB, Liddle, PF.Neural sources involved in auditory target detection and novelty processing: an event-related fMRI study. Psychophysiology 2001;38: 133–142. Google ScholarPubMed
Opitz, B, Mecklinger, A, Von Cramon, DY, Kruggel, F.Combining electrophysiological and hemodynamic measures of the auditory oddball. Psychophysiology 1999b;36: 142–147. CrossRefGoogle ScholarPubMed
Clark, VP, Fannon, S, Lai, S, Benson, R, Bauer, L.Responses to rare visual target and distractor stimuli using event-related fMRI. J Neurophysiol 2000;83: 3133–3139. CrossRefGoogle ScholarPubMed
Downar, J, Crawley, AP, Mikulis, DJ, Davis, KD.A multimodal cortical network for the detection of changes in the sensory environment. Nat Neurosci 2000;3: 277–283. CrossRefGoogle Scholar
Risold, PY, Swanson, LW.Structural evidence for functional domains in the rat hippocampus. Science 1996;272: 1484–1486. CrossRefGoogle ScholarPubMed
Damasio, AR.Descartes' error. New York: Putnam, 1994. Google ScholarPubMed
Rolls, ET.The brain and emotion. Oxford: Oxford University Press, 1999. Google Scholar
Iversen, SD, Mishkin, M.Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity. Exp Brain Res 1970;11: 376–386. CrossRefGoogle ScholarPubMed
Jones, B, Mishkin, M.Limbic lesions and the problem of stimulus – reinforcement associations. Exp Neurol 1972;36: 362–377. CrossRefGoogle ScholarPubMed
Rolls, ET, Hornak, J, Wade, D, McGrath, J.Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry 1994;57: 1518–1524. CrossRefGoogle ScholarPubMed
O'Doherty, J, Rolls, ET, Francis, Set al. Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex. Neuroreport 2000; 11: 893–897. CrossRefGoogle ScholarPubMed
Fabiani, M, Friedman, D.Changes in brain activity patterns in aging: the novelty oddball. Psychophysiology 1995;32: 579–594. CrossRefGoogle ScholarPubMed
Goldman-Rakic, PS.Working memory and the mind. Sci Am 1992;267: 110–117. CrossRefGoogle ScholarPubMed