Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-23T04:48:41.710Z Has data issue: false hasContentIssue false
  • English
  • Français

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Published online by Cambridge University Press:  24 June 2014

Bjanka Vuksan-Ćusa ,
Darko Marčinko ,
Sanea Nad  and
Miro Jakovljević
Bjanka Vuksan-Ćusa
Affiliation:
Department of Psychiatry, University Hospital Centre, Zagreb
Darko Marčinko
Affiliation:
Department of Psychiatry, General Hospital Virovitica, Virovitica, Croatia
Sanea Nad
Affiliation:
Department of Psychiatry, General Hospital Virovitica, Virovitica, Croatia
Miro Jakovljević
Affiliation:
Department of Psychiatry, General Hospital Virovitica, Virovitica, Croatia
Get access Rights & Permissions [Opens in a new window]

Abstract:

Patient with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome (MetS) and its components compared to general population. Among psychiatric disorders, bipolar disorder ranks highest in suicidality with a relative risk ratio of completed suicide of about 25 compared to the general population. Regarding the biological hypotheses of suicidality, low blood cholesterol level has been extensively explored, although results are still conflicting. The aim of this study was to investigate whether there were differences in the serum cholesterol levels in hospitalized bipolar disorder men patients with history of suicide attempts (n= 20) and without suicide attempts (n= 20). Additionally, we investigated if there were differences in the prevalence of MetS according to NCEP ATP-III criteria in these two groups of patients. Results of the study indicated significantly lower serum cholesterol levels (P = 0.013) and triglyceride levels (P = 0.047), in the bipolar disorder men with suicide attempts in comparison to bipolar disorder men without suicide attempts. The overall prevalence of MetS was 11/40 (27.5%). On this particular sample it was higher in the non-attempters 8/20 (40.0%) than in attempters 3/20 (15.0%) bipolar men group, but without statistical significance. Lower concentrations of serum cholesterol might be useful biological markers of suicidality in men with bipolar disorder.

Type
Inpc Young Psychiatrists Programme
Information
Acta Neuropsychiatrica , Volume 21 , Issue S2: Special Issue: Abstracts of 49th Neuropsychiatric Pula Congress, 17-20 June 2009, Pula, Croatia , June 2009 , pp. 66 - 69
Copyright
Copyright © 2009 John Wiley & Sons A/S

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References:

Alexander, C, Landsman, P, Teutsch, S, Haffner, S.NCEP –defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003;52:1210–1214.CrossRefGoogle ScholarPubMed
Atmaca, M, Kuloglu, M, Tezcan, E, Ustundag, B, Gecici, O, Firidin, B.Serum leptin and cholesterol values in suicide attempters. Neuropsychobiology 2002;45:124–127.CrossRefGoogle ScholarPubMed
Atmaca, M, Kuloglu, M, Tezcan, E, Ustundag, B.Serum leptin and cholesterol values in violent and non-violent suicide attempters. Psychiatry Res 2008;158(1):87–91.CrossRefGoogle ScholarPubMed
Baldessarini, RJ, Tondo, L 2003. Suicide risk and treatments for patients with bipolar disorder. JAMA;290:1517–1519.CrossRefGoogle ScholarPubMed
Baldessarini, RJ, Pompili, M, Tondo, L.Suicide in bipolar disorder: Risks and management. CNS Spectr 2006;11(6):465–471.CrossRefGoogle ScholarPubMed
Bocchetta, A, Chillotti, C, Carboni, G, Oi, A, Ponti, M, Del Zompo, M. Association of personal and familial suicide risk with low serum cholesterol concentration in male lithium patients. Acta Psychiatr Scand 2001;104(1)37–41.CrossRefGoogle ScholarPubMed
Bonora, E, Targher, G, Fomentini, G, Calcaterra, F, Lombardi, S, Marini, Fet al.The metabolic syndrome is an independent predictor of the cardiovascular disease in type 2 diabetic subjects. Prospective data from Verona Diabetes Complications Study. Diabet Med 2004;21:52–58.CrossRefGoogle ScholarPubMed
Cardenas, J, Frye, MA, Marusak, SL, Levander, ME, Chirichigno, WJ, Lewis, Set al.Modal subcomponents of metabolic syndrome in patients with bipolar disorder. J Affect Disord 2008;106:91–97.CrossRefGoogle ScholarPubMed
Deisenhammer, EA, Kramer-Reinstadler, K, Liensberger, D, Kemmler, G, Hinterhuber, H, Fleischhacker, WW.No evidence for an association between serum cholesterol and the course of depression and suicidality. Psychiatry Research 2004;121:253–261.CrossRefGoogle ScholarPubMed
Executive Summary: The Third Report ofthe National Cholesterol Education Program (NCEP). Expert Panel on detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486–2497.CrossRefGoogle Scholar
Fagiollini, A, Kupfer, DJ, Houck, PR, Novick, DM, Frank, E.Obesity as a correlate of outcome in patient. The prevalence of metabolic syndrome in patients with bipolar disorder. J Affect Disord 2003;106:197–201.Google Scholar
Fiedorowicz, JG, Coryell, WH.Cholesterol and suicide attempts: A prospective study of depressed patients. Psychiatry Res 2007;152(1):11–20.CrossRefGoogle Scholar
Garcia–Portilla, MP, Saiz, PA, Benabarre, A, Sierra, P, Perez, J, Rodriguez, Aet al.The prevalence of metabolic syndrome in patients with bipolar disorder. J Affect Disord 2008;197–201.CrossRefGoogle ScholarPubMed
Goldberg, et al.Correlates of suicidal ideation in dysporic mania. J Affect Disord 1999;56;75–81.CrossRefGoogle ScholarPubMed
Guillem, E, Pelissolo, A, Notides, C, Lepine, JP.Relationship between attempted suicide, serum cholesterol level and novelty seeking in psychiatric in-patients. Psychiatry Res 2002;112:83–88.CrossRefGoogle ScholarPubMed
Guy, W. ECDEU assessment manual for psychopharmacology, revised. Bethesda MD: US Department of Health, Education and Welfare, 1976.Google Scholar
Kim, YK, Lee, HJ, Kim, JY, Yoon, DK, Choi, SH, Lee, MS.Low serum cholesterol is correlated to suicidality in a Korean sample. Acta Psychiatr Scand 2002;105:141–148.CrossRefGoogle Scholar
Laaksonen, DE, Laaka, HM, Niskanen, L, Kaplan, G, Salonen, J, Laaka, T.Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 2002;156:1070–1077.CrossRefGoogle ScholarPubMed
Lee, HJ, Kim, YK.Serum lipid levels and suicide attempts. Acta Psychiatr Scand 2003;108:215–221.CrossRefGoogle ScholarPubMed
Marčinko, D, Martinac, M, Karlović, D, Lonccar, Č.Cholesterol serum levels in violent and non-violent young male schizophrenic suicide attempters. Psych Danubina 2004;16: 161–164.Google ScholarPubMed
Marčinko, D, Martinać, M, Karlovic, D, Filipčić, I, Lončar, Č, Pivac, N, Jakovljević, M.Are There Differences in Serum Cholesterol and Cortisol Concentrations Between Violent and Non-Violent Schizophrenic Male Suicide Attempters? Coll Antropol 2005;30:153–157.Google Scholar
Marčinko, D, Pivac, N., Martinac, M., Jakovljevic, M., Mihaljević-Peleš, A, Muck-Šeler, D. Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis. Psychiatry Res 2007;150:105–108.CrossRefGoogle ScholarPubMed
Marčinko, D, Marčinko, A, Jakovljević, M, ordević, V, Gregurek, R, Henigsberg, Net al.Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder. Coll Antropol 2007;31(3):113–117.Google Scholar
Marčinko, D, Marčinko, V, Karlović, D, Marčinko, A, Martinac, M, Begic, D, Jakovljević, M.Serum lipid levels and suicidality among male patients with schizoaffective disorder. Prog Neu-ropsychopharmacol Biol Psychiatry 2008;32(1):193–196.CrossRefGoogle ScholarPubMed
Newcomer, JW.Metabolic syndrome and mental illness. Am J Manag Care 2007;13(11):170–177.Google ScholarPubMed
Nuggent, Ap.The metabolic syndrome. Food Nutr Bull 2004;29:36.Google Scholar
Oquendo, MA, Waternaux, C Brodsky, Parsons, B, Haas, GL, Malone, KMet al.Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and non-attempters. J Affect Disord 2000;59:107–117.CrossRefGoogle Scholar
Overall, JE, Gorham, DR.The Brief Psychiatric rating Scale. Psychol Res 1962;10:799–812.Google Scholar
Roy, A, Gonzalez, B, Marcus, A, Berman, J.Serum cholesterol, suicidal behavior and impulsivity in cocaine-dependent patients. Psychiatry Res 2001;101:243–247.CrossRefGoogle ScholarPubMed
Ryan, MCM, Thakore, JH.Physical consequences of schizophrenia and its treatment; the metabolic syndrome (mini review). Life Sci 2002;71:239–257.CrossRefGoogle Scholar
Sarchiapone, M, Camardese, G, Roy, A, Della Casa, S, Satta, MA, Gonzales, Bet al.Cholesterol and serotonin indices in depressed and suicidal patients. J Affect Disord 2001;62:217–219.CrossRefGoogle ScholarPubMed
Stanley, B, Traskman Bendz, L, Stanley, M. The Suicide Assesment Scale: a scale evaluating change in suicidal behaviour. Psychopharm Bull 1986;1:200–205.Google Scholar
Strakowski, SM, McElroy, SL, Keck, PE, West, SA.Suicidality among patients with mixed and manic bipolar disorder. Am J Psychiatry 1996;153:674–676.Google ScholarPubMed
Tsai, SY, Kuo, CJ, Chen, CC, Lee, HC.Risk factors for completed suicide in bipolar disorder. J Clin Psychiatry 2002;63:469–476.CrossRefGoogle ScholarPubMed
Valtonen, H, Suominen, K, Mantere, O, Leppamaki, S, Arvilommi, P, Isometsa, E.Suicide ideation and attempts in bipolar I and II disorders. J Clin Psychiatry 2005;66:1456–1462.CrossRefGoogle ScholarPubMed
Valtonen, H, Suominen, K, Mantere, O, Leppamaki, S, Arvilommi, P, Isometsa, E.Suicidal behaviour during different phases of bipolar disorder. J Affect Disord 2007;97:101–107.CrossRefGoogle ScholarPubMed
Yumru, M, Savas, HA, Kurt, E, Kaya, MC, Selek, S, Savas, Eet al.. Atypical antipsychotic related metabolic syndrome in bipolar patients. J Affect Disord 2007;98:247–252.CrossRefGoogle ScholarPubMed
Young, RC, Biggs, JT, Ziegler, VE, Meyer, DA.A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:149–435.CrossRefGoogle ScholarPubMed
World Health Organization. World Health Organization International Statistical Classification of Diseases and related health Problems, Tenth Revision. Switzerland, Geneva, 1996.Google Scholar
Zalsman, G, Braun, M, Arendt, M, Grunebaum, MF, Sher, L, Burke, et al.A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders. Bipolar Disor 2006;8:558–565.CrossRefGoogle ScholarPubMed