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Correlation between white blood cell count and mood-stabilising treatment response in two bipolar disorder trials

Published online by Cambridge University Press:  06 June 2019

Ole Köhler-Forsberg Open the ORCID record for Ole Köhler-Forsberg [Opens in a new window] ,
Louisa G. Sylvia ,
Charles L. Bowden ,
Joseph R. Calabrese ,
Michael E. Thase ,
Richard C. Shelton ,
Melvin McInnis ,
Mauricio Tohen ,
James H. Kocsis  and
Terence A. Ketter
...Show all authors
Ole Köhler-Forsberg*
Affiliation:
Department of Clinical Medicine, Aarhus University Psychosis Research Unit, Aarhus University Hospital Psychiatry, Aarhus, Denmark
Louisa G. Sylvia
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Charles L. Bowden
Affiliation:
Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
Joseph R. Calabrese
Affiliation:
Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
Michael E. Thase
Affiliation:
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Richard C. Shelton
Affiliation:
Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL, USA
Melvin McInnis
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Mauricio Tohen
Affiliation:
Department of Psychiatry, University of New Mexico Health Science Center, Albuquerque, NM, USA
James H. Kocsis
Affiliation:
Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA
Terence A. Ketter
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Edward S. Friedman
Affiliation:
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Thilo Deckersbach
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Michael J. Ostacher
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Dan V. Iosifescu
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Susan McElroy
Affiliation:
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH and Lindner Center of HOPE, Mason, OH, USA
Andrew A. Nierenberg
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
*
Author for correspondence: Ole Köhler-Forsberg, Email: [email protected]
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Abstract

Background:

Immune system markers may predict affective disorder treatment response, but whether an overall immune system marker predicts bipolar disorder treatment effect is unclear.

Methods:

Bipolar CHOICE (N = 482) and LiTMUS (N = 283) were similar comparative effectiveness trials treating patients with bipolar disorder for 24 weeks with four different treatment arms (standard-dose lithium, quetiapine, moderate-dose lithium plus optimised personalised treatment (OPT) and OPT without lithium). We performed secondary mixed effects linear regression analyses adjusted for age, gender, smoking and body mass index to investigate relationships between pre-treatment white blood cell (WBC) levels and clinical global impression scale (CGI) response.

Results:

Compared to participants with WBC counts of 4.5–10 × 109/l, participants with WBC < 4.5 or WBC ≥ 10 showed similar improvement within each specific treatment arm and in gender-stratified analyses.

Conclusions:

An overall immune system marker did not predict differential treatment response to four different treatment approaches for bipolar disorder all lasting 24 weeks.

Keywords

bipolar disorderlithiumquetiapinetreatment responsewhite blood cell
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 31 , Issue 4 , August 2019 , pp. 230 - 234
Copyright
© Scandinavian College of Neuropsychopharmacology 2019 

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