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Congenital malformations caused by psychotropic drugs in pregnancy

Published online by Cambridge University Press:  18 September 2015

G. de Cuypere ,
Ph. Rombaut  and
M. van Moffaert
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Summary

After a description of the harmful effects of psychotropic drugs as well as of the moments of vulnerability to any teratogenic effect, this paper reviews prospective, retrospective and epidemiological studies of the teratogenic effects of anticonvulsants (phenytoin, valproic acid, carbamazepine and barbiturates), lithium, anti-psychotics, benzodiazepines and anti-depressive agents. It is found that the results of these studies are not unequivocal. Only lithium and valproic acid are shown to be teratogenic. In cases where malformations of the fetus are observed, the treatment often consisted in a combination of various psychotropic drugs.

The review is completed with data on the psychopharmacological problems during delivery and their side-effects on the newborn.

Keywords

anticonvulsantslithiumantipsychotic drugsbenzodiazepinesantidepressantsteratogenicitypregnancyanti-epilepticalithiumantipsychoticabenzodiazepinen en antidepressivateratogeniciteitzwangerschap
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 4 , Issue 4 , December 1992 , pp. 77 - 85
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1994

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