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A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

Published online by Cambridge University Press:  24 June 2014

Shiguo Liu ,
Yanhui Liu ,
Yingying Yin ,
Xinhua Zhang  and
Xu Ma
Shiguo Liu
Affiliation:
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China Institute of Clinical Research, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Yanhui Liu
Affiliation:
Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Yingying Yin
Affiliation:
Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Xinhua Zhang*
Affiliation:
Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Xu Ma*
Affiliation:
Graduate school, Peking Union Medical College, Beijing, China National Research Institute for Family Planning, Beijing, China World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
*
Xinhua Zhang, MD, Department of psychiatry, Medical College, Qingdao University, 16 Jiangsu Road, Qingdao 266003, China. Tel: +86 053282912012; Fax: +86 053282912016; E-mail: [email protected]
Professor Xu Ma, Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081 China. Tel: +86 10 62176870; Fax: +86 10 62179151; E-mail: [email protected]
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Extract

Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.

Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.

Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (X2 = 2.12, df = 2, P = 0.35 by genotype; X2 = 0.005, df = 1, P = 0.94 by allele).

Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.

Keywords

interleukin-12obsessive-compulsive disorderpolymorphism
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 3 , June 2012 , pp. 172 - 175
Copyright
Copyright © Cambridge University Press 2011

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