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Baseline working memory activation deficits in dimensional anxious depression as detected by magnetoencephalography

Published online by Cambridge University Press:  20 January 2015

Dawn F. Ionescu ,
Allison C. Nugent ,
David A. Luckenbaugh ,
Mark J. Niciu ,
Erica M. Richards ,
Carlos A. Zarate Jr.  and
Maura L. Furey
Dawn F. Ionescu*
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Allison C. Nugent
Affiliation:
Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
David A. Luckenbaugh
Affiliation:
Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Mark J. Niciu
Affiliation:
Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Erica M. Richards
Affiliation:
Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Carlos A. Zarate Jr.
Affiliation:
Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Maura L. Furey
Affiliation:
Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
*
Dawn F. Ionescu, Massachusetts General Hospital, Depression Clinical and Research Program, 1 Bowdoin Square, Floor 6, MA 02114, Boston. Tel: +1 617 643 0491; Fax: +1 617 724 3028; E-mail: [email protected]
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Abstract

Objective

Anxiety often co-occurs with major depressive disorder (MDD). This preliminary study sought to ascertain the extent to which anxious depression drives group neurobiological differences between patients with MDD and healthy volunteers (HVs).

Methods

Magnetoencephalography beta-band frequency was used to compare differences in brain response during the N-back working memory task between 30 medication-free patients with treatment-resistant MDD (anxious depression=18; nonanxious depression=12) and 28 HVs.

Results

Compared to HVs, patients with anxious depression had significantly reduced desynchronisation (less activation) in the left precuneus, right cuneus, and left insula extending into the inferior and middle frontal cortex during the 2-back condition compared with the 1-back condition of the N-back working memory task – indicating less activation of these neural networks in patients with anxious depression during the condition with the highest level of task demands. No other significant group differences were found during the working memory conditions.

Conclusion

This preliminary study suggests that a subset of patients – those with anxious depression – may be driving observed group differences between patients with MDD and HVs. Further neurobiological studies and replication experiments are necessary to determine the extent to which this subgroup has preferentially influenced our understanding of the underlying neurobiology of depression.

Keywords

anxious depressionmagnetoencephalography (MEG)major depressive disorderN-back taskneurobiology
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 3 , June 2015 , pp. 143 - 152
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015. This is a work of the U.S. Government and is not subject to copyright protection in the United States. 

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References

1.Rush, AJ. The varied clinical presentations of major depressive disorder. J Clin Psychiatry 2007;68(Suppl. 8):4–10.Google ScholarPubMed
2.American Psychiatric Association & American Psychiatric Association. Task Force on DSM-IV. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, 4th edn.Washington, DC: American Psychiatric Association, 2000.Google Scholar
3.Cleary, P, Guy, W. Factor analysis of Hamilton depression scale. Drugs Exp Clin Res 1977;1:115–120.Google Scholar
4.Fava, M, Rush, AJ, Alpert, JEet al. Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. Am J Psychiatry 2008;165:342–351.CrossRefGoogle ScholarPubMed
5.Fava, M, Alpert, JE, Carmin, CNet al. Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D. Psychol Med 2004;34:1299–1308.CrossRefGoogle ScholarPubMed
6.Fava, M, Rush, AJ, Alpert, JEet al. What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extension. Can J Psychiatry 2006;51:823–835.CrossRefGoogle ScholarPubMed
7.Papakostas, GI, Fan, H, Tedeschini, E. Severe and anxious depression: combining definitions of clinical sub-types to identify patients differentially responsive to selective serotonin reuptake inhibitors. Eur Neuropsychopharmacol 2012;22:347–355.CrossRefGoogle ScholarPubMed
8.Farabaugh, A, Alpert, J, Wisniewski, SRet al. Cognitive therapy for anxious depression in STAR(*) D: what have we learned? J Affect Disord 2012;142:213–218.CrossRefGoogle Scholar
9.Nelson, JC. Anxiety does not predict response to duloxetine in major depression: results of a pooled analysis of individual patient data from 11 placebo-controlled trials. Depress Anxiety 2010;27:12–18.CrossRefGoogle Scholar
10.Papakostas, GI, Larsen, K. Testing anxious depression as a predictor and moderator of symptom improvement in major depressive disorder during treatment with escitalopram. Eur Arch Psychiatry Clin Neurosci 2011;261:147–156.CrossRefGoogle ScholarPubMed
11.Smits, JA, Minhajuddin, A, Thase, ME, Jarrett, RB. Outcomes of acute phase cognitive therapy in outpatients with anxious versus nonanxious depression. Psychother Psychosom 2012;81:153–160.CrossRefGoogle ScholarPubMed
12.Wiethoff, K, Bauer, M, Baghai, TCet al. Prevalence and treatment outcome in anxious versus nonanxious depression: results from the german algorithm project. J Clin Psychiatry 2010;71:1047–1054.CrossRefGoogle ScholarPubMed
13.Wu, Z, Chen, J, Yuan, Cet al. Difference in remission in a Chinese population with anxious versus nonanxious treatment-resistant depression: a report of OPERATION study. J Affect Disord 2013;150:834–839.CrossRefGoogle Scholar
14.Chan, HN, Rush, AJ, Nierenberg, AAet al. Correlates and outcomes of depressed out-patients with greater and fewer anxious symptoms: a CO-MED report. Int J Neuropsychopharmacol 2012;15:1387–1399.CrossRefGoogle ScholarPubMed
15.Thase, ME, Demyttenaere, K, Earley, WR, Gustafsson, U, Udd, M, Eriksson, H. Extended release quetiapine fumarate in major depressive disorder: analysis in patients with anxious depression. Depress Anxiety 2012;29:574–586.CrossRefGoogle ScholarPubMed
16.Ionescu, DF, Niciu, MJ, Mathews, DC, Richards, EM, Zarate, CA Jr. Neurobiology of anxious depression: a review. Depress Anxiety 2013;30:374–385.CrossRefGoogle ScholarPubMed
17.Deiber, MP, Missonnier, P, Bertrand, Oet al. Distinction between perceptual and attentional processing in working memory tasks: a study of phase-locked and induced oscillatory brain dynamics. J Cogn Neurosci 2007;19:158–172.CrossRefGoogle ScholarPubMed
18.Krause, CM, Pesonen, M, Hamalainen, H. Brain oscillatory 4-30 Hz electroencephalogram responses in adolescents during a visual memory task. Neuroreport 2010;21:767–771.CrossRefGoogle ScholarPubMed
19.Pesonen, M, Hamalainen, H, Krause, CM. Brain oscillatory 4–30 Hz responses during a visual n-back memory task with varying memory load. Brain Res 2007;1138:171–177.CrossRefGoogle ScholarPubMed
20.Brookes, MJ, Wood, JR, Stevenson, CMet al. Changes in brain network activity during working memory tasks: a magnetoencephalography study. Neuroimage 2011;55:1804–1815.CrossRefGoogle ScholarPubMed
21.Austin, MP, Mitchell, P, Goodwin, GM. Cognitive deficits in depression: possible implications for functional neuropathology. Br J Psychiatry 2001;178:200–206.CrossRefGoogle ScholarPubMed
22.Harvey, PO, Le Bastard, G, Pochon, JBet al. Executive functions and updating of the contents of working memory in unipolar depression. J Psychiatr Res 2004;38:567–576.CrossRefGoogle ScholarPubMed
23.Rose, EJ, Ebmeier, KP. Pattern of impaired working memory during major depression. J Affect Disord 2006;90:149–161.CrossRefGoogle ScholarPubMed
24.Xu, G, Lin, K, Rao, Det al. Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: a longitudinal, naturalistic study. J Affect Disord 2012;136:328–339.CrossRefGoogle ScholarPubMed
25.Antikainen, R, Hanninen, T, Honkalampi, Ket al. Mood improvement reduces memory complaints in depressed patients. Eur Arch Psychiatry Clin Neurosci 2001;251:6–11.CrossRefGoogle ScholarPubMed
26.Salvadore, G, Cornwell, BR, Sambataro, Fet al. Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine. Neuropsychopharmacology 2010;35:1415–1422.CrossRefGoogle Scholar
27.First, MBSR, Gibbon, M, Williams, JBW. Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, DC: American Psychiatric Press, 1997.Google Scholar
28.McClintock, SM, Husain, MM, Bernstein, IHet al. Assessing anxious features in depressed outpatients. Int J Methods Psychiatr Res 2011;20:e69–e82.CrossRefGoogle ScholarPubMed
29.Fletcher, PC, Henson, RN. Frontal lobes and human memory: insights from functional neuroimaging. Brain 2001;124:849–881.CrossRefGoogle ScholarPubMed
30.S. E. Robinson, JV. Functional neuroimaging by synthetic aperture magnetometry (SAM). Sendai, Japan: Tohoku University Press, 1999.Google Scholar
31.Nolte, G. The magnetic lead field theorem in the quasi-static approximation and its use for magnetoencephalography forward calculation in realistic volume conductors. Phys Med Biol 2003;48:3637–3652.CrossRefGoogle ScholarPubMed
32.Callicott, JH, Mattay, VS, Bertolino, Aet al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex 1999;9:20–26.CrossRefGoogle ScholarPubMed
33.Talairach, JTP. Co-planar stereotaxic atlas of the human brain: an approach to cerebral imaging. New york, NY: Thieme Medical Publishers, 1988.Google Scholar
34.Hahn, B, Ross, TJ, Stein, EA. Neuroanatomical dissociation between bottom-up and top-down processes of visuospatial selective attention. Neuroimage 2006;32:842–853.CrossRefGoogle ScholarPubMed
35.Owen, AM, McMillan, KM, Laird, AR, Bullmore, E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 2005;25:46–59.CrossRefGoogle ScholarPubMed
36.Pernet, C, Franceries, X, Basan, S, Cassol, E, Demonet, JF, Celsis, P. Anatomy and time course of discrimination and categorization processes in vision: an fMRI study. Neuroimage 2004;22:1563–1577.CrossRefGoogle ScholarPubMed
37.Schneider-Garces, NJ, Gordon, BA, Brumback-Peltz, CRet al. CRUNCH, and beyond: working memory capacity and the aging brain. J Cogn Neurosci 2010;22:655–669.CrossRefGoogle ScholarPubMed
38.Heller, W. The neuropsychology of emotion: developmental patterns and implications for psychopathology. In: Stein NL and Hillsdale NJ, editors. Psychological and biological approaches to emotion. Hillsdale, New Jersey, USA: Lawrence Erlbaum Associates, Inc., Publishers, 1990.Google Scholar
39.Heller, W, Etienne, MA, Miller, GA. Patterns of perceptual asymmetry in depression and anxiety: implications for neuropsychological models of emotion and psychopathology. J Abnorm Psychol 1995;104:327–333.CrossRefGoogle ScholarPubMed
40.Ionescu, DF, Niciu, MJ, Henter, ID, Zarate, CA. Defining anxious depression: a review of the literature. CNS Spectr 2013;18:252–260.CrossRefGoogle ScholarPubMed