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Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese

Published online by Cambridge University Press:  24 June 2014

Mei Shi ,
Jian Hu ,
Xuesong Dong ,
Yue Gao ,
Ganghui An ,
Wei Liu ,
Li Chen  and
Xueying Sun
Mei Shi
Affiliation:
Department of Psychiatric and Psychology
Jian Hu
Affiliation:
Department of Psychiatric and Psychology
Xuesong Dong
Affiliation:
The Hepatosplenic Surgery Center/Department of General Surgery, The First Clinical Medical School
Yue Gao
Affiliation:
The Hepatosplenic Surgery Center/Department of General Surgery, The First Clinical Medical School
Ganghui An
Affiliation:
Department of Psychiatric and Psychology
Wei Liu
Affiliation:
Department of Psychiatric and Psychology
Li Chen
Affiliation:
Department of Medical Psychology, The Institute of Public Health, Harbin Medical University, Harbin, China
Xueying Sun*
Affiliation:
The Hepatosplenic Surgery Center/Department of General Surgery, The First Clinical Medical School
*
Dr Xueying Sun, The Hepatosplenic Surgery Center/Department of General Surgery, The First Clinical Medical School, Harbin Medical University, Harbin 150001, China. Tel/Fax: +86 451 53643628; E-mail: [email protected]
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Abstract

Objective:

The present study aims to investigate the association of unipolar depression (UPD) with six serotonergic gene polymorphisms in Han Chinese.

Methods:

One hundred and thirty-two UPD patients and 180 healthy controls were genotyped for polymorphisms of six serotonergic genes, including tryptophan hydroxylase (TPH1 A218C), serotonin transporter promoter region (5-HTTLPR), serotonin receptor 2A (5-HT2AR −1438G/A), serotonin receptor 2C (5-HT2CR Cys23Ser), serotonin receptor 6 (5-HT6R C267T) and serotonin receptor 1Dβ (5-HT1DβR T371G). Symptomatic clusters were evaluated by the 24-item Hamilton Rating Scale for Depression (HAMD).

Results:

The frequencies of S/S genotype and S allele in 5-HTTLPR polymorphism were significantly higher in UPD patients than in healthy controls. There was a significant difference in distributions of genotypes in 5-HT2CR Cys23Ser polymorphism between UPD patients and control subjects, but the difference became no significant when the data were further stratified by gender. The patients with genotypes G/G and T/G of 5-HT1DβR T371G polymorphism had significantly lower scores of diurnal variation evaluated by HAMD than those with genotype T/T, while the patients with genotype T/G had significantly higher scores of hopelessness than those with genotypes G/G and T/T. There were no significant differences in genotypic and allelic distributions of TPH1 A218C, 5-HT2AR −1438G/A or 5-HT6R C267T polymorphisms between the case and control groups.

Conclusion:

The study demonstrates that 5-HTTLPR and 5-HT2CR Cys23Ser polymorphisms might contribute to susceptibility of UPD, and the genotype T/T in 5-HT1DβR T371G polymorphism might be a risk factor for diurnal variation, while T/G might be a protective factor against hopelessness in Han Chinese populations.

Keywords

gene polymorphismserotoninunipolar depression
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 3 , June 2008 , pp. 139 - 144
Copyright
Copyright © 2008 Blackwell Munksgaard

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