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Association of FK506 binding protein 5 (FKBP5) gene rs4713916 polymorphism with mood disorders: a meta-analysis

Published online by Cambridge University Press:  24 June 2014

Xiao-Liang Feng ,
Fang Wang ,
Yan-Feng Zou ,
Wen-Fei Li ,
Yang-Hua Tian ,
Fa-Ming Pan  and
Fen Huang
Xiao-Liang Feng
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
Fang Wang
Affiliation:
Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, China
Yan-Feng Zou*
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
Wen-Fei Li
Affiliation:
Department of Psychiatry, the 4th People's Hospital of Hefei, Hefei, China
Yang-Hua Tian
Affiliation:
Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China
Fa-Ming Pan
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
Fen Huang
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
*
Yan-Feng Zou, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China. Tel: +86 105513869140; Fax: +86 105513869140; E-mail: [email protected]
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Extract

Background: Several studies have investigated the association of FKBP5 gene polymorphisms with mood disorders, but findings are not always consistent. The aim of our study was to assess the association of FKBP5 gene polymorphisms with mood disorders using a meta-analysis.

Methods: Data were collected from the following electronic databases: PubMed, Elsevier Science Direct, Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang, with the last report up to March 2010. Meta-analysis was performed in a fixed/random effect model.

Results: We identified six studies using search, and one study was excluded because of unavailable data. One study contained data on two different ethnicities and we treated them independently. Thus, six separate studies (2655 cases and 3593 controls) were included in the meta-analysis. Meta-analysis was performed for three FKBP5 gene polymorphisms (rs1360780, rs3800373 and rs4713916) in overall and Caucasian populations. We did not detect any association of FKBP5 gene rs1360780 and rs3800373 polymorphisms with mood disorders (p > 0.05). However, a significant association of FKBP5 gene rs4713916 polymorphism with mood disorders was found, and the heterozygous individual (GA genotype) was more susceptible to mood disorders in comparison to homozygous analogues (GG or AA genotype) [overall: GA vs. GG: OR (odds ratio) = 1.20, 95% CI (confidence interval) = 1.03–1.40, p = 0.02; GA vs. AA: OR = 1.44, 95% CI = 1.09–1.90, p = 0.009; Caucasian: GA vs. GG: OR = 1.22, 95% CI = 1.04–1.44, p = 0.01; GA vs. AA: OR = 1.43, 95% CI = 1.09–1.89, p = 0.01].

Conclusion: This meta-analysis shows that mood disorders are associated with FKBP5 gene rs4713916 polymorphism, but not with rs1360780 and rs3800373.

Keywords

FK506 binding protein 5genetic polymorphismsmeta-analysismood disorders
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 23 , Issue 1 , February 2011 , pp. 12 - 19
Copyright
Copyright © Cambridge University Press 2011

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