Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-27T00:59:43.806Z Has data issue: false hasContentIssue false
  • English
  • Français

Association between the NOTCH4 gene rs3131296 polymorphism with schizophrenia risk in the Chinese Zhuang population and Chinese Han population

Published online by Cambridge University Press:  27 February 2014

Li Su Open the ORCID record for Li Su [Opens in a new window] ,
Jianxiong Long ,
Baoyun Liang ,
Lian Gu ,
Runde Pan ,
Liushan Li ,
Yang Zhou ,
Xianyan Tang ,
Junjun Jiang  and
Qiang Chen
...Show all authors
Li Su
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Jianxiong Long
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Baoyun Liang
Affiliation:
Department of Internal Neurology, First Affiliated Hospital to Guangxi University of Chinese Medicine, Nanning, Guangxi, PR China
Lian Gu
Affiliation:
Department of Internal Neurology, First Affiliated Hospital to Guangxi University of Chinese Medicine, Nanning, Guangxi, PR China
Runde Pan
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, PR China
Liushan Li
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Yang Zhou
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Xianyan Tang
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Junjun Jiang
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Qiang Chen*
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, PR China
Bo Wei*
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
*
Qiang Chen, Guangxi Brain Hospital, Liuzhou, Guangxi, PR China. Tel: 13907723846; Fax: +867723136028; Email: [email protected]
Bo Wei, School of Public Health of Guangxi Medical University, Guangxi, PR China. Tel: 13978668658; Fax: +867715350823; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Schizophrenia (SZ) is a common severe psychiatric disorder and a complex polygenic inherited disease that has not yet been fully interpreted. Heredity was proven to play an important role in the development of SZ. The association between the NOTCH4 gene rs3131296 polymorphism and SZ was reported to reach significance at the genome-wide level; therefore, it is necessary to replicate this association in other different populations.

Methods

To evaluate the association of the NOTCH4 gene rs3131296 polymorphism with the risk for SZ, and to explore whether a significant association could be replicated in different ethnic groups of China, we conducted this case–control study on 282 SZ cases (188 Han and 94 Zhuang) and 282 controls (188 Han and 94 Zhuang) among the Chinese Zhuang and Han populations.

Results

The results showed no statistically significant difference in the genotype or allele frequencies of the NOTCH4 gene variant rs3131296 between SZ patients and healthy controls in either the Zhuang or Han samples (p > 0.05). In addition, no significant difference was found in genotype or allele frequencies of the NOTCH4 gene variant rs3131296 between cases and controls in the combined samples including Zhuang and Han samples.

Conclusions

Our study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for SZ.

Keywords

association studyNOTCH4polymorphismrs3131296schizophrenia
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 26 , Issue 4 , August 2014 , pp. 240 - 245
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Li Su, Jianxiong Long, Baoyun Liang, and Lian Gu co-first authors for this article.

References

1. McGrath, JJ. The surprisingly rich contours of schizophrenia epidemiology. Arch Gen Psychiatry 2007;64:14–16.CrossRefGoogle ScholarPubMed
2. Cardno, AG, Gottesman, II. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 2000;97:12–17.3.0.CO;2-U>CrossRefGoogle ScholarPubMed
3. Sullivan, PF, Kendler, KS, Neale, MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003;60:1187–1192.CrossRefGoogle ScholarPubMed
4. Uyttendaele, H, Marazzi, G, Wu, G, Yan, Q, Sassoon, D, Kitajewski, J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 1996;122:2251–2259.CrossRefGoogle ScholarPubMed
5. Lewis, CM, Levinson, DF, Wise, LH et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 2003;73:34–48.CrossRefGoogle ScholarPubMed
6. Louvi, A, Artavanis-Tsakonas, S. Notch signalling in vertebrate neural development. Nat Rev Neurosci 2006;7:93–102.CrossRefGoogle ScholarPubMed
7. Lewis, DA, Levitt, P. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 2002;25:409–432.CrossRefGoogle ScholarPubMed
8. Allen, NC, Bagade, S, McQueen, MB et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008;40:827–834.CrossRefGoogle ScholarPubMed
9. Glatt, SJ, Wang, RS, Yeh, YC, Tsuang, MT, Faraone, SV. Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses. Schizophr Res 2005;73:281–290.CrossRefGoogle ScholarPubMed
10. Wang, Z, Wei, J, Zhang, X et al. A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2006;141B:902–906.CrossRefGoogle ScholarPubMed
11. Shibata, N, Ohnuma, T, Higashi, S et al. Genetic association between Notch4 polymorphisms and Japanese schizophrenics. Psychiatr Genet 2006;16:77–79.CrossRefGoogle ScholarPubMed
12. Liu, CM, Liu, YL, Fann, CS et al. Association evidence of schizophrenia with distal genomic region of NOTCH4 in Taiwanese families. Genes Brain Behav 2007;6:497–502.CrossRefGoogle ScholarPubMed
13. Betcheva, ET, Mushiroda, T, Takahashi, A et al. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957 T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 2009;54:98–107.CrossRefGoogle Scholar
14. Tochigi, M, Zhang, X, Umekage, T et al. Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. Am J Med Genet B Neuropsychiatr Genet 2004;128B:37–40.CrossRefGoogle ScholarPubMed
15. Tochigi, M, Zhang, X, Ohashi, J et al. Association study between the TNXB locus and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet 2007;144B:305–309.CrossRefGoogle Scholar
16. Stefansson, H, Ophoff, RA, Steinberg, S et al. Common variants conferring risk of schizophrenia. Nature 2009;460:744–747.CrossRefGoogle ScholarPubMed
17. Li, T, Li, Z, Chen, P et al. Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry 2010;68:671–673.CrossRefGoogle ScholarPubMed
18. Lou, H, Li, S, Yang, Y et al. A map of copy number variations in Chinese populations. PLoS One 2011;6:e27341.CrossRefGoogle ScholarPubMed
19. Peng, S, Lu, XM, Luo, HR, Xiang-Yu, JG, Zhang, YP. Melanocortin-1 receptor gene variants in four Chinese ethnic populations. Cell Res 2001;11:81–84.Google ScholarPubMed
20. Halley, L, Doherty, MK, Megson, IL, McNamara, N, Gadja, A, Wei, J. Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population. Immunogenetics 2013;65:1–7.CrossRefGoogle ScholarPubMed
21. Li, M, Luo, XJ, Xiao, X et al. Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia. Am J Psychiatry 2011;168:1318–1325.CrossRefGoogle ScholarPubMed
22. Li, M, Zhang, H, Luo, XJ et al. Meta-analysis indicates that the European GWAS-identified risk SNP rs1344706 within ZNF804A is not associated with schizophrenia in Han Chinese population. PLoS One 2013;8:e65780.CrossRefGoogle Scholar
23. Tian, C, Kosoy, R, Lee, A et al. Analysis of East Asia genetic substructure using genome-wide SNP arrays. PLoS One 2008;3:e3862.CrossRefGoogle ScholarPubMed
24. Owen, MJ, Craddock, N, O'Donovan, MC. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Arch Gen Psychiatry 2010;67:667–673.CrossRefGoogle ScholarPubMed