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[3H]Pirenzepine binding in the pathology of schizophrenia: studies in Brodmann's area 6

Published online by Cambridge University Press:  24 June 2014

A Soulby ,
B Dean  and
E Scarr
A Soulby
Affiliation:
Mental Health Research Institute, Melbourne, Australia
B Dean
Affiliation:
Mental Health Research Institute, Melbourne, Australia
E Scarr
Affiliation:
Mental Health Research Institute, Melbourne, Australia
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Abstract

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Type
Abstracts from ‘Brainwaves’— The Australasian Society for Psychiatric Research Annual Meeting 2006, 6–8 December, Sydney, Australia
Information
Acta Neuropsychiatrica , Volume 18 , Issue 6 , December 2006 , pp. 308
Copyright
Copyright © 2006 Blackwell Munksgaard

Background:

Changes in muscarinic receptors are widespread in the brains of subjects with schizophrenia, implicating them in the pathology of the disorder (Hyde & Crook Chem Neuroanat 2001, 22 53–63). A previous study showed decreased levels of mRNA for the muscarinic M1 receptor in Brodmann's area (BA) 6 from subjects with schizophrenia (Mancama et al. Am J Med Genet B Neuropsychiatr Genet 2003, 119 2–6). The purpose of our study was to further investigate this finding.

Methods:

Using in situ radioligand binding and autoradiography, the density of [3H]pirenzepine binding was determined in BA 6 obtained postmortem from 20 subjects with schizophrenia and 20 subjects with no psychiatric history (controls).

Results:

[3H]Pirenzepine binding was differentially distributed in the cortical gray matter (inner layer = gray1; outer layer = gray2). [3H]Pirenzepine binding was significantly lower in tissue from subjects with schizophrenia than in that from control subjects in both gray1 (mean ± SEM, 74.56 ± 10.67 vs. 118.80 ± 5.47 fmol//mgETE, P < 0.01) and gray2 layers (102.90 ± 14.09 vs. 152.90 ± 8.04, P < 0.01). Furthermore, [3H]pirenzepine binding was significantly different between layers in control subject tissue (gray1, 118.80 ± 5.47; gray2, 152.90 ± 8.04; P < 0.05), but not in that from subjects with schizophrenia (gray1, 74.56 ± 10.67; gray2 102.90 ± 14.09; P > 0.05).

Conclusion:

These results support previous findings that levels of M1 and/or M4 muscarinic receptors are significantly altered in cortical regions from subjects with schizophrenia, extending the regions affected to include BA6.