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Series:   Elements in Molecular Oncology

Therapeutic Targeting of RAS Mutant Cancers

Published online by Cambridge University Press:  26 August 2022

Edward C. Stites ,
Kendra Paskvan  and
Shumei Kato
Edward C. Stites
Affiliation:
Salk Inst itute for Biological Studies, La Jolla, CA
Kendra Paskvan
Affiliation:
Pacific Northwes t University for Health Sciences, Yakima, WA
Shumei Kato
Affiliation:
University of California, San Diego Moores Cancer Center

Summary

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
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Keywords

KRAScovalent inhibitortargeted therapypersonalized medicineG12C
Type
Element
Information
Series: Elements in Molecular Oncology
Online ISBN: 9781009064828
Publisher: Cambridge University Press
Print publication: 15 September 2022

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Therapeutic Targeting of RAS Mutant Cancers
  • Edward C. Stites, Salk Inst itute for Biological Studies, La Jolla, CA, Kendra Paskvan, Pacific Northwes t University for Health Sciences, Yakima, WA, Shumei Kato, University of California, San Diego Moores Cancer Center
  • Online ISBN: 9781009064828
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Therapeutic Targeting of RAS Mutant Cancers
  • Edward C. Stites, Salk Inst itute for Biological Studies, La Jolla, CA, Kendra Paskvan, Pacific Northwes t University for Health Sciences, Yakima, WA, Shumei Kato, University of California, San Diego Moores Cancer Center
  • Online ISBN: 9781009064828
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Therapeutic Targeting of RAS Mutant Cancers
  • Edward C. Stites, Salk Inst itute for Biological Studies, La Jolla, CA, Kendra Paskvan, Pacific Northwes t University for Health Sciences, Yakima, WA, Shumei Kato, University of California, San Diego Moores Cancer Center
  • Online ISBN: 9781009064828
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