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Series:   Elements in Molecular Oncology

Targeting Oncogenic Driver Mutations in Lung Cancer

Published online by Cambridge University Press:  12 January 2023

Matthew Lee ,
Fawzi Abu Rous ,
Alain Borczuk ,
Stephen Liu ,
Shirish Gadgeel  and
Balazs Halmos
Matthew Lee
Affiliation:
Montefiore Medical Center and Albert Einstein College of Medicine
Fawzi Abu Rous
Affiliation:
Henry Ford Health System
Alain Borczuk
Affiliation:
Weill Cornell Medicine
Stephen Liu
Affiliation:
Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC
Shirish Gadgeel
Affiliation:
Henry Ford Health System
Balazs Halmos
Affiliation:
Montefiore Medical Center and Albert Einstein College of Medicine

Summary

The recent advances in the field of molecular diagnostic techniques have led to the identification of targetable alterations prompting a paradigm shift in the management of non-small cell lung cancer (NSCLC) and an era of precision oncology. This Element highlights the most clinically relevant oncogenic drivers other than EGFR, their management and current advancements in treatment. It also examines the different challenges in resistance to targeted therapies and diagnostic dilemmas for each oncogenic driver and the future direction of NSCLC management.
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Keywords

non-small cell lung cancertargetable mutations/alterationsresistance mechanismsdiagnostic techniquesdriver mutations
Type
Element
Information
Series: Elements in Molecular Oncology
Online ISBN: 9781009336123
Publisher: Cambridge University Press
Print publication: 02 February 2023

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Targeting Oncogenic Driver Mutations in Lung Cancer
  • Matthew Lee, Montefiore Medical Center and Albert Einstein College of Medicine, Fawzi Abu Rous, Henry Ford Health System, Alain Borczuk, Weill Cornell Medicine, Stephen Liu, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, Shirish Gadgeel, Henry Ford Health System, Balazs Halmos, Montefiore Medical Center and Albert Einstein College of Medicine
  • Online ISBN: 9781009336123
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Targeting Oncogenic Driver Mutations in Lung Cancer
  • Matthew Lee, Montefiore Medical Center and Albert Einstein College of Medicine, Fawzi Abu Rous, Henry Ford Health System, Alain Borczuk, Weill Cornell Medicine, Stephen Liu, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, Shirish Gadgeel, Henry Ford Health System, Balazs Halmos, Montefiore Medical Center and Albert Einstein College of Medicine
  • Online ISBN: 9781009336123
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Targeting Oncogenic Driver Mutations in Lung Cancer
  • Matthew Lee, Montefiore Medical Center and Albert Einstein College of Medicine, Fawzi Abu Rous, Henry Ford Health System, Alain Borczuk, Weill Cornell Medicine, Stephen Liu, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, Shirish Gadgeel, Henry Ford Health System, Balazs Halmos, Montefiore Medical Center and Albert Einstein College of Medicine
  • Online ISBN: 9781009336123
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