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  3. Thermodynamic Theory of Site-Specific Binding Processes in Biological Macromolecules
  • Cited by 39
Publisher:
Cambridge University Press
Online publication date:
December 2009
Print publication year:
1995
Online ISBN:
9780511524837
DOI:
https://doi.org/10.1017/CBO9780511524837
Subjects:
Life Sciences, Chemistry, Chemistry: General Interest, Molecular Biology, Biochemistry, and Structural Biology
Information

Book description

This book provides the first systematic treatment of the thermodynamic theory of site-specific effects in biological macromolecules. It describes the phenomenological and conceptual bases required to allow a mechanistic understanding of these effects from analysis of experimental data. The thermodynamic theory also results in novel experimental strategies that enable the derivation of information on local, site-specific properties of a macromolecular system from analysis of perturbed global properties. The treatment focuses on binding phenomena, but is amenable to extension both conceptually and formally to the analysis of other cooperative processes, such as folding and helix–coil transitions. This book will interest any scientist involved in structure–function studies of biological macromolecules, or as a text for graduate students in biochemistry and biophysics.

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