Principles of Pharmacogenetics and Pharmacogenomics

doi:10.1017/CBO9781139051194

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This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

Nickola, Tracey J Green, James S Harralson, Arthur F and O‘Brien, Travis J 2012. The Current and Future State of Pharmacogenomics Medical Education in the USA. Pharmacogenomics, Vol. 13, Issue. 12, p. 1419.

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Nickola, Tracey J and Munson, Amanda M 2014. Pharmacogenomics Primer Course for First Professional Year Pharmacy Students. Pharmacogenomics, Vol. 15, Issue. 1, p. 39.

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Edited by Russ B. Altman, Stanford University, California, David Flockhart, Indiana University, David B. Goldstein, Duke University, North Carolina

Publisher:: Cambridge University Press
Online publication date:: June 2012
Print publication year:: 2012
Online ISBN:: 9781139051194
DOI:: https://doi.org/10.1017/CBO9781139051194

Subjects:: Genetics, Life Sciences, Pharmacology

95.00 (GBP)

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The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

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Principles of Pharmacogenetics and Pharmacogenomics

This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Contributors
pp vii-x

Introduction
pp xi-xii

I - Critical Concepts
pp 1-2

1 - Introduction to Population Diversity and Genetic Testing
pp 3-11

2 - Genotyping Technologies
pp 12-20

3 - Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion Overview Chapter
pp 21-26

4 - Overview: Adverse Drug Reactions
pp 27-37

5 - PharmGKB, a Centralized Resource for Pharmacogenomic Knowledge and Discovery
pp 38-54

6 - DrugBank
pp 55-65

7 - Ethical Considerations for Pharmacogenomics: Privacy and Confidentiality
pp 66-73

8 - Informed Consent in Pharmacogenomic Research and Treatment
pp 74-80

9 - Legal Trends Driving the Clinical Translation of Pharmacogenomics
pp 81-94

II - Therapeutic Areas
pp 95-96

10 - Oncologic Drugs
pp 97-114

11 - Pharmacogenetics and Pharmacogenomics of Cardiovascular Disease
pp 115-124

12 - Statin-Induced Muscle Toxicity
pp 125-135

13 - Genomics of the Drug-Induced Long-QT Syndrome
pp 136-144

14 - Pharmacogenetics of Diabetes
pp 145-153

15 - Pharmacogenetics – Therapeutic Area – Respiratory
pp 154-174

16 - Pharmacogenomics Associated with Therapy for Acid-Related Disorders
pp 175-187

17 - Pharmacogenetics of Rheumatology: Focus on Rheumatoid Arthritis
pp 188-201

18 - Pharmacogenetics of Obstetric Therapeutics
pp 202-216

19 - Pharmacogenomics of Psychiatric Drugs
pp 217-223

20 - Pain and Anesthesia
pp 224-237

21 - HIV and Antiretroviral Therapy
pp 238-248

22 - Application of Pharmacogenetics and Pharmacogenomics in Pediatrics: What Makes Children Different?
pp 249-262

23 - Fetal and Neonatal Pharmacogenomics
pp 263-269

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Principles of Pharmacogenetics and Pharmacogenomics

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