Contents

pp vii-viii

List of contributors

pp ix-x

Preface

pp xi-xii

Acknowledgments

pp xiii-xiv

Section 1 - Definition, history, methodology, and assessment

1 - Early rehabilitative intervention

pp 1-14

2 - The history of early intervention for infants and young children with Down syndrome and their families

pp 15-35

3 - Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome

pp 36-51

Section 2 - Genetics, brain, and animal models

4 - New perspectives on molecular and genic therapies in Down syndrome

pp 52-70

5 - Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome

pp 71-84

6 - Development of the brain and metabolism

pp 85-95

Section 3 - Pharmacological and medical management and treatment

7 - Pharmacotherapy for children with Down syndrome

pp 96-116

8 - Early medical caretaking and follow-up

pp 117-127

9 - Evaluation and management of cardiovascular diseases in Down syndrome

pp 128-141

Section 4 - Early development and intervention

10 - Developmental models as frameworks for early intervention with children with Down syndrome

pp 142-152

11 - Aspects of motor development in Down syndrome

pp 153-163

12 - Memory development and learning

pp 164-174

13 - Prelinguistic and early development, stimulation, and training in children with Down syndrome

pp 175-181

14 - Speech perception, stimulation, and phonological development

pp 182-190

15 - Goal-directedness as a target for early intervention in Down syndrome

pp 191-204

16 - The role of parents of children with Down syndrome and other disabilities in early intervention

pp 205-223

Section 5 - Therapeutic perspectives

17 - Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome

pp 224-229

Conclusions

pp 230-230

Index

pp 231-237