Brain Repair After Stroke

doi:10.1017/CBO9780511777547

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Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

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Contents

Brain Repair After Stroke - Half title page
pp i-ii
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Brain Repair After Stroke - Title page
pp iii-iii
- By Steven C. Cramer, Randolph J. Nudo
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Copyright page
pp iv-iv
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Contents
pp v-vi
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Preface
pp vii-vii
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Contributors
pp viii-x
- By DeAnna L. Adkins, Samir Belagaje, S. Thomas Carmichael, Alex R. Carter, John Chae, François Chollet, Michael Chopp, Leonardo G. Cohen, Maurizio Corbetta, Steven C. Cramer, Rick M. Dijkhuizen, Megan Farrell, Seth P. Finklestein, Leigh R. Hochberg, Barbro B Johansson, Theresa A. Jones, Brett Kissela, Jeffrey A. Kleim, Bryan Kolb, J. Leigh Leasure, Yi Li, Isabelle Loubinoux, Andreas Luft, Randolph J. Nudo, Stephen J. Page, Thomas Platz, Valerie M. Pomeroy, David J. Reinkensmeyer, JingMei Ren, J. C. Rothwell, Dorothee Saur, Timothy Schallert, Gottfried Schlaug, Susan Schwerin, Rüdiger J. Seitz, Gordon L. Shulman, O. Swayne, P. Talelli, G. Campbell Teskey, Maurits P. A. van Meer, Nick S. Ward, Cornelius Weiller, Carolee J. Winstein, Steven L. Wolf
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Section I. - Basic Science and Animal Studies
pp 1-86
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1 - Motor map plasticity:
pp 1-10
a neural substrate for improving motor function after stroke
- By Jeffrey A. Kleim, Susan Schwerin
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2 - Molecular mechanisms of neural repair after stroke
pp 11-22
- By S. Thomas Carmichael
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3 - Behavioral influences on neuronal events after stroke
pp 23-34
- By Theresa A. Jones, DeAnna L. Adkins
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4 - Post-stroke recovery therapies in animals
pp 35-46
- By G. Campbell Teskey, Bryan Kolb
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5 - Environmental effects on functional outcome after stroke
pp 47-56
- By Barbro B. Johansson
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6 - Functional and structural MR imaging of brain reorganization after stroke
pp 57-66
- By Maurits P. A. van Meer, Rick M. Dijkhuizen
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7 - Stroke recovery in non-human primates:
pp 67-76
a comparative perspective
- By Randolph J. Nudo
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8 - Issues in translating stroke recovery research from animals to humans
pp 77-86
- By J. Leigh Leasure, Andreas Luft, Timothy Schallert
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Section II. - Spontaneous Stroke Recovery in Humans
pp 87-172
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9 - Brain events in the acute period of stroke in relation to subsequent repair
pp 87-102
- By Rüdiger J. Seitz
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10 - Changes in cortical excitability and interhemispheric interactions after stroke
pp 103-112
- By P. Talelli, O. Swayne, J. C. Rothwell
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11 - Human brain mapping of the motor system after stroke
pp 113-124
- By Nick S. Ward
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12 - Recovery from aphasia:
pp 125-132
lessons from imaging studies
- By Cornelius Weiller, Dorothee Saur
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13 - Brain mapping of attention and neglect after stroke
pp 133-144
- By Alex R. Carter, Gordon L. Shulman, Maurizio Corbetta
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14 - Depression and its effects after stroke
pp 145-162
- By Thomas Platz
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15 - Epidemiology of stroke recovery
pp 163-172
- By Samir Belagaje, Brett Kissela
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Section III. - Treatment Strategies
pp 173-274
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16 - Issues in clinical trial methodology for brain repair after stroke
pp 173-182
- By Steven C. Cramer
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17 - Neuropharmacology in stroke recovery
pp 183-194
- By Isabelle Loubinoux, François Chollet
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18 - Robotic approaches to stroke recovery
pp 195-206
- By David J. Reinkensmeyer
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19 - Electromagnetic approaches to stroke recovery
pp 207-218
- By Gottfried Schlaug, Leonardo G. Cohen
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20 - Intensive physical therapeutic approaches to stroke recovery
pp 219-232
- By Steven L. Wolf, Carolee J. Winstein
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21 - Cognitive approaches to stroke recovery
pp 233-246
- By Valerie M. Pomeroy, Stephen J. Page, Megan Farrell
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Brain Repair After Stroke

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Contents

Brain Repair After Stroke - Half title page
pp i-ii

Brain Repair After Stroke - Title page
pp iii-iii

Copyright page
pp iv-iv

Contents
pp v-vi

Preface
pp vii-vii

Contributors
pp viii-x

Section I. - Basic Science and Animal Studies
pp 1-86

1 - Motor map plasticity:
pp 1-10

2 - Molecular mechanisms of neural repair after stroke
pp 11-22

3 - Behavioral influences on neuronal events after stroke
pp 23-34

4 - Post-stroke recovery therapies in animals
pp 35-46

5 - Environmental effects on functional outcome after stroke
pp 47-56

6 - Functional and structural MR imaging of brain reorganization after stroke
pp 57-66

7 - Stroke recovery in non-human primates:
pp 67-76

8 - Issues in translating stroke recovery research from animals to humans
pp 77-86

Section II. - Spontaneous Stroke Recovery in Humans
pp 87-172

9 - Brain events in the acute period of stroke in relation to subsequent repair
pp 87-102

10 - Changes in cortical excitability and interhemispheric interactions after stroke
pp 103-112

11 - Human brain mapping of the motor system after stroke
pp 113-124

12 - Recovery from aphasia:
pp 125-132

13 - Brain mapping of attention and neglect after stroke
pp 133-144

14 - Depression and its effects after stroke
pp 145-162

15 - Epidemiology of stroke recovery
pp 163-172

Section III. - Treatment Strategies
pp 173-274

16 - Issues in clinical trial methodology for brain repair after stroke
pp 173-182

17 - Neuropharmacology in stroke recovery
pp 183-194

18 - Robotic approaches to stroke recovery
pp 195-206

19 - Electromagnetic approaches to stroke recovery
pp 207-218

20 - Intensive physical therapeutic approaches to stroke recovery
pp 219-232

21 - Cognitive approaches to stroke recovery
pp 233-246

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Brain Repair After Stroke

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