Originally published in 1994, this was the first volume to look in depth at the way the brain responds to trauma and subsequently integrates and influences behavioural, metabolic, neurohumoral, cardiovascular and immune functions. At the time, the role of the brain in the control and integration of the responses to injury and infection was becoming increasingly clear. It had been established that some of these responses, such as fever and neuroendocrine changes, responded to the direct influence of the central nervous system. These, and other advances, provided fresh insights into this area and formed a basis for the more effective understanding and clinical management of trauma patients. In this volume, the authors, all international authorities in their fields, discuss data from experimental and clinical studies and considered the implications of these findings for the treatment of the trauma patient.

"This is a notable contribution, of wider potential clinical interest than might appear, since virtually all types of bodily insult or damage rather than 'trauma' in the sense only of injury, are brought into the same integrative perspective." Sheila Jennett, Journal of the Royal Society of Medicine

"...an interesting approach to the primarily chemical study of cerebral tissue responses to trauma." Electroencephalography and Clinical Neurophysiology