Mead and Bateson were two of the most famous and influential anthropologists whose research and advocacy have had broad influences on social sciences and mental health in the twentieth century. Although their marriage lasted only four years, they continued to influence each other until their dying days. After Mead’s death, their only daughter, Catherine Bateson, also an accomplished anthropologist, found out that Mead had been a closet lesbian since her early adulthood, and for years was a lover of another famous anthropologist, Ruth Benedict. These entangled relationships are described and discussed in the context of their achievements and contributions. Also included in the narratives are Mead’s original fieldwork in American Samoa and controversies surrounding Samoan teenagers’ sex life; Mead’s relationship with Benjamin Spock and their influences on contemporary child-rearing practices; Bateson’s complicated and tragic family background; and Bateson’s contributions to systems biology, double bind theory, and cybernetics.