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25 - Immunization against herpes zoster

from Part V - Treatment and Prevention

Published online by Cambridge University Press:  02 March 2010

Ann M. Arvin
Affiliation:
Stanford University School of Medicine, California
Anne A. Gershon
Affiliation:
Columbia University, New York
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Summary

Introduction

Reactivation resulting in infectious VZV in ganglia may occur sporadically throughout life, but the clinical importance of this phenomenon may be limited by VZV-specific immune responses. This might be accomplished either by a direct mechanism to inhibit reactivation or by rapid local clearing of reactivated virus, such that no signs or symptoms occur (subclinical reactivation). Infectious VZV has not been recovered from ganglia at autopsy, except in the special circumstance where the deceased had HZ at the time of death. There are no data on reactivation frequency as a function of age, but the concept of subclinical reactivation is supported by fluctuations in VZV-specific antibody and asymptomatic viremia observed during longitudinal studies of certain populations (Gershon et al., 1982; Ljungman et al., 1986; Wilson et al., 1992), and by case reports of neuropathic syndromes without cutaneous manifestations (zoster sine herpete) (Barrett et al., 1993; Gilden et al., 1994). Subclinical reactivation might be an important factor in maintaining VZV-specific immunity long after primary infection with varicella.

Role of VZV-specific immunity

There is very strong evidence that deficient VZV-specific immunity is closely correlated with the occurrence of clinically apparent reactivation.

Type
Chapter
Information
Varicella-Zoster Virus
Virology and Clinical Management
, pp. 500 - 519
Publisher: Cambridge University Press
Print publication year: 2000

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