This chapter explores the medical systems developed in precolonial and colonial Nigeria, the social, economic, and political processes which impacted the development of said medical institutions/practices, and how these systems, in turn, impacted the social, economic, and political landscape of colonial Nigeria. This chapter will use several significant pandemics, such as the 1918 influenza pandemic, to explain how Nigeria’s medical and nonmedical systems interacted during immense medical stress. The medical practices and policies explored were highly regionalized, and each Indigenous population had its specialized form of healthcare. When Nigeria was brought under the colonial fold, certain regions received more or less assistance in developing medical facilities. These developments were primarily driven by economic interests underpinned by a racist political and social system, often leading to disastrous consequences.