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3 - Science and Technology of Ultrananocrystalline Diamond (UNCD™) Coatings for Glaucoma Treatment Devices

Published online by Cambridge University Press:  08 July 2022

By
Alejandro Berra ,
Mario J. Saravia ,
Pablo Gurman  and
Orlando Auciello
Edited by
Orlando Auciello
Orlando Auciello
Affiliation:
University of Texas, Dallas
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Summary

This chapter describes the science and technology to develop extremely biocompatible UNCD coatings for encapsulation of devices to treat the glaucoma condition, related to clogging of natural tubes in the human eye’ trabecular mesh, which continuously drain the eye’ fluid from the inner part to keep the internal eye pressure constant. Clogging of the tubes produce overpressure in the eye, resulting in the destruction of the optical nerve and blindness. Two types of devices are being developed by the authors of this chapter, namely: 1) Hydrophobic (no eye fluid adsorption) UNCD coating on commercial polymer-based drain valves (hydrophilic-eye’ fluid adsorption), to practically eliminate attachment of proteins on hydrophilic polymer surface, thus fibrosis that reduce implant lifetime. 2)The second device consists of a novel metallic multi-hole circular grid, made of Ti, coated with a UNCD film and implanted in the eye’ trabecular region, providing efficient drainage of the eye’ fluid through the many holes existing in the structure. The UNCD-coated grid provides a smaller, less intrusive and more efficient device for treatment of glaucoma than the current commercial much larger valves based on polymers, which exhibit extensive biofouling.

Keywords

Biocompatible,hydrophobicultrananocrystalline diamond (UNCD)coatingencapsulationcomercialpolymerglaucoma valve
Type
Chapter
Information
Ultrananocrystalline Diamond Coatings for Next-Generation High-Tech and Medical Devices , pp. 107 - 120
Publisher: Cambridge University Press
Print publication year: 2022

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