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4 - Science and Technology of Novel Integrated Biocompatible Superparamagnetic Oxide Nanoparticles Injectable in the Human Eye and External Ultrananocrystalline Diamond (UNCD™)-Coated Magnet for a New Retina Reattachment Procedure

Published online by Cambridge University Press:  08 July 2022

By
Mario J. Saravia ,
Roberto D. Zysler ,
Enio Lima ,
Pablo Gurman  and
Orlando Auciello
Edited by
Orlando Auciello
Orlando Auciello
Affiliation:
University of Texas, Dallas
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Summary

Retinal detachment is the separation of the sensory retinal tissue from the underlying pigmented epithelium, resulting in partial or total loss of human vision. Worldwide, 1:10,000 people per year suffer retina’s detachment. Current treatments include: 1) repositioning the sensory retina onto the rest of the retinal tissue, sealing the gap via laser heating or external freezing treatment. Current therapies for retina’s reattachment include using a silicone ring or a gas bubble to push the retina back into place. These modalities suffer from drawbacks such as choroidal detachment when using the silicone ring, or postoperative positioning of the patient. These techniques are not optimal for treating retinal detachment in the lower part of the eye. Thus, this chapter describes R&D that demonstrated a revolutionary method for retina reattachment, using a solution containing iron oxide super-paramagnetic nanoparticles (FDA approved) injected in the vitreous space of a rabbit eye and a rare earth magnet implanted on the sclera region outside the eye. Superparamagnetic particles, magnetic only when exposed to a magnetic field, are attracted to the magnet area pushing the retina back into place, then dissolve when the magnet is extracted.The magnet is coated with a biocompatible Ultrananocrystalline Diamond (UNCD) coating.

Keywords

dettachedhuman eye retinareacttachedpushedFDA approvedsuperparamagnetic nanoparticlesattractedmagnetic fieldproducedUNCD-coated external magnet
Type
Chapter
Information
Ultrananocrystalline Diamond Coatings for Next-Generation High-Tech and Medical Devices , pp. 121 - 140
Publisher: Cambridge University Press
Print publication year: 2022

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References

Encyclopedia Britannica, “Sensory reception: human vision: structure and function of the human eye,” in Encyclopedia Britannica vol. 27, 1987. Edinburgh: Encyclopaedia Britannica.Google Scholar
Goldberg, A. F., Moritz, O. L., and Williams, D. S., “Molecular basis for photoreceptor outer segment architecture,” Prog. Retin. Eye Res., vol. 55, p. 52, 2016.Google Scholar
Arshavsky, V. Y. and Burns, M. E., “Photoreceptors signaling supporting vision across a wide range of light intensities,” J. Biol. Chem., vol. 287 (3), p. 1620, 2012.CrossRefGoogle ScholarPubMed
Sparrow, J. R., Hicks, D., and Hamel, C. P., “The retinal pigment epithelium in health and disease,” Curr. Mol. Med., vol. 10 (9): p. 802, 2010.Google Scholar
Letelier, J., Bovolenta, P., and Martínez-Morales, J. B., “The pigmented epithelium, a bright partner against photoreceptor degeneration,” J. Neurogenet., vol. 31 (4), p. 203, 2017.Google Scholar
Shepherd, G., The Synaptic Organization of the Brain. New York: Oxford University Press, 2004.Google Scholar
Johnson, D. and Hollands, H., “Acute-onset flatters and flashes,” Can. Med. Assoc. J., vol. 184 (4), p. 431, 2011.Google Scholar
Cline, D., Hofstetter, H. W., and Griffin, J. R., Dictionary of Visual Science, 4th ed. Boston, MA: Butterworth-Heinemann, 1997.Google Scholar
Gelston, C. D., “Common eye emergencies,” Am. Fam. Physic., vol. 88 (8), p. 515, 2013.Google Scholar
Mitry, D., Charteris, D. G., Fleck, B. W., Campbell, H., and Singh, J., “The epidemiology of hematogenous retinal detachment: geographical variation and clinical associations,” Br. J. Ophthalmol., vol. 94 (6), p. 678, 2010.Google Scholar
Byer, N., “Natural history of posterior vitreous detachment with early management as the premier line of defense against retinal detachment,” Ophthalmology, vol. 101 (9), p. 1503, 1994.Google Scholar
Dickerman, R. D., Smith, G. H., Langham-Roof, L., et al., “Intra-ocular pressure changes during maximal isometric contraction: does this reflect intra-cranial pressure or retinal venous pressure?,” Neurol. Res., vol. 21 (3), p. 243, 1999.CrossRefGoogle ScholarPubMed
Shields, J. A. and Shields, C. L., “Treatment of retinoblastoma with cryotherapy,” Trans. Pa. Academi Ophthalmol. Otolaryngol., vol. 42, p. 977, 1990.Google Scholar
Augsburger, J. J. and Faulkner, C. B., “Indirect ophthalmoscope argon laser treatment of retinoblastoma,” Ophthalmic Surg., vol. 23 (9), p. 591, 1992.Google ScholarPubMed
Banerjee, P. J., Chandra, A., Petrou, P., and Charteris, D. G., “Silicone oil versus gas tamponade for giant retinal tear-associated fovea-sparing retinal detachment: a comparison of outcome,” Eye (Lond.), vol. 31 (9), p. 1302, 2017.Google Scholar
Moharram, H. M., Abdelhalim, A. S., Hamid, M. A., and Abdelkader, M. F., “Comparison between oil and gas in tamponade giant retina breaks,” Clin. Ophthalmol., vol. 14, p. 127, 2020.CrossRefGoogle Scholar
Ratanasukon, M., Kittantong, A., Visaetsilpanonta, S., and Somboonthanakij, S., “Pars plana vitrectomy with silicone oil or gas endotamponade in HIV-related rhegmatogenous retinal detachments in Thai patients,” J. Med. Assoc. Thai, vol. 90(6), p. 1161, 2007.Google Scholar
Wang, Yi-X. J., Xuan, S., Port, M., and Idee, J-M., “Recent advances in superparamagnetic iron oxide nanoparticles for cellular imaging and targeted therapy research,” Curr. Pharmaceut. Design, vol. 19, 6575, 2013.Google Scholar
Hanini, A., Schmitt, A., Kacem, K., et al., “Evaluation of iron oxide nanoparticle biocompatibility,” Int. J. Nanomed., vol. 6, p. 787, 2011.Google ScholarPubMed
Kowalczyk, M., Banach, M., and Rysz, J., “Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease,” J. Nephrol., vol. 24 (6), p. 717, 2011.CrossRefGoogle ScholarPubMed
Prow, T. W., Bhutto, I., Kim, S. Y., et al., “Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium,” Nanomed. Nanotechnol. Biol. Med., vol. 4 (4), p. 340, 2008.Google Scholar
Weissleder, R., Stark, D. D., Engelstad, B. L., et al. “Superparamagnetic iron oxide: pharmacokinetics and toxicity,” Am. J. Roentgenol., vol. 152 (1), p. 167, 1989.CrossRefGoogle ScholarPubMed
Stefansson, E., “Ocular oxygenation and the treatment of diabetic retinopathy,” Surv. Ophthalmol., vol. 51, p. 364, 2006.Google Scholar
Yeh, P.-T., Yang, C.-M., Yang, C.-H., and Huang, J.-S., “Cryotherapy of the anterior retina and sclerotomy sites in diabetic vitrectomy to prevent recurrent vitreous hemorrhage,” Am. Acad. Ophthalmol. , vol. 112 (12), p. 2095, 2005.Google ScholarPubMed
Triantafyllou, M., Studer, U. E., Birkhauser, F. D., et al., “Ultrasmall superparamagnetic particles of iron oxide allow for the detection of metastases in normal sized pelvic lymph nodes of patients with bladder and/or prostate cancer,” Eur. J. Cancer, vol. 49 (3), p. 616, 2013.Google Scholar
Harisinghani, M. G., Barentsz, J., Hahn, P. F., et al., “Noninvasive detection of clinically occult lymph-node metastases in prostate cancer,” New Engl. J. Med., vol. 348 (25), p. 2491, 2003.CrossRefGoogle ScholarPubMed
Jeun, M., Jeoung, J. W., Moon, S., et al., “Engineered superparamagnetic Mn0.5 Zn0.5 Fe2O4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma,” Biomaterials, vol. 32 (2), p. 387, 2011.Google Scholar
Jeun, M., Kim, Y. J., Park, K. H., Paek, S. H., and Bae, S., “Physical contribution of Néel and Brown relaxation to interpreting intracellular hyperthermia characteristics using superparamagnetic nanofluids,” J. Nanosci. Nanotechnol., vol. 13 (8), p. 5719, 2013.CrossRefGoogle Scholar
Buitrago, E., Del Sole, M. J., Torbidoni, A., et al., “Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma,” Exp. Eye Res., vol. 108, p. 103, 2013.Google Scholar
Ghassemi, F., Shields, C. L., Ghadimi, H., Khodabandeh, A., and Roohipoor, R., “Combined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma,” JAMA Ophthalmol., vol. 132, p. 936, 2014.CrossRefGoogle ScholarPubMed
Nicolas, P., Saleta, M., Troiani, H., et al., “Preparation of iron oxide nanoparticles stabilized with biomolecules: experimental and mechanistic issues,” Acta Biomaterialia, vol. 9 (1), p. 4754, 2013.Google Scholar
Raineri, M., Winkler, E. L., Torres, T. E., et al., “Effects of biological buffer solutions on the peroxidase-like catalytic activity of Fe3O4 nanoparticles,” Nanoscale, 2019. doi: 10.1039/C9NR05799D.CrossRefGoogle Scholar
Mojica Pisciotti, M. L., Lima, E., Jr., Vasquez Mansilla, M., et al., “In vitro and in vivo experiments with iron oxide nanoparticles functionalized with DEXTRAN or polyethylene glycol for medical applications: Magnetic targeting,” J. Biomed. Mater. Res. B, vol. 102, p. 860, 2014.Google Scholar
Zysler, R. D., Lima, E. Jr., Vasquez Mansilla, M., et al., “A new quantitative method to determine the uptake of SPIONs in animal tissue and its application to determine the quantity of nanoparticles in the liver and lung of Balb-c mice exposed to the SPIONs,” J. Biomed. Nanotechnol., vol. 9 (1), p. 142, 2013.Google Scholar
Harrison, J., Bartlett, C. A., Cowin, G., et al., “In vivo imaging and biodistribution of multimodal polymeric nanoparticles delivered to the optic nerve,” Small, vol. 8 (10), p. 1579, 2012.Google Scholar
Yanai, A., Häfeli, U. O., Metcalfe, A. L., et al., “Focused magnetic stem cell targeting to the retina using superparamagnetic iron oxide nanoparticles,” Cell Transplant., vol. 21 (6), p. 1137, 2012.CrossRefGoogle Scholar
Wen, J., McKenna, K. C., Barron, B. C., Langston, H. P., and Kapp, J. A., “Use of superparamagnetic microbeads in tracking subretinal injections,” Mol. Vis., vol. 11, p. 256, 2005.Google Scholar
Fandiño, L. A. C. and Saravia, M., “Guiones de Oftalmologia,” in Capitulo: Ediciones Universidad de Valladolid, Jimeno, J. C. P., Ed. Valladolid: Universidad de Valladolid, p. 320, 1993.Google Scholar
Zysler, R., Berra, A., Gurman, P., Auciello, O., and Saravia, M. J., “Material for medical use comprising nanoparticles with superparamagnetic properties and its utilization in surgery,” US Patent #9,427,354, 2016.Google Scholar
Zysler, R., Berra, A., Gurman, P., Auciello, O., and Saravia, M. J., “Material for medical use comprising nanoparticles with superparamagnetic properties and its utilization in surgery,” Japanese Patent #5,954,797 (2016).Google Scholar
Fortuin, A. S. and Barentsz, J. O., “Comments on Ultrasmall superparamagnetic particles of iron oxide allow for the detection of metastases in normal sized pelvic lymph nodes of patients with bladder and/or prostate cancer,” Eur. J. Cancer, vol. 49 (7), p. 1789, 2013.Google Scholar
Dimaras, H., Kimani, K., Dimba, E. A., et al., “Retinoblastoma,” Lancet, vol. 379 (9824), p. 1436, 2012.Google Scholar
Wang, A. Z., Bagalkot, V., Vasilliou, C. C., et al., “Super-paramagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy,” Chem. Med. Chem., vol. 3(9), p. 1311, 2008.Google Scholar
Kowalczyk, M., Banach, M, and Rysz, J, “Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease,” J. Nephrol., vol. 24(6), p. 717, 2011.Google Scholar
Vargas, J. M. and Zysler, R. D., “Tailoring the size in colloidal iron oxide magnetic nanoparticles,” Nanotechnology, vol. 16, p. 1474, 2005.CrossRefGoogle Scholar
Moreno Maldonado, A. C., Winkler, E. L., Raineri, M., et al. “Free radical formation by the peroxidase-like catalytic activity of MFe2O4 (M = Fe, Ni and Mn) nanoparticles,” J. Phys. Chem. C, vol. 123, p. 20617, 2019.CrossRefGoogle Scholar
Reddy, K. R., Reddy, P. A., Reddy, C. V., et al., “Functionalized magnetic nanoparticles/ biopolymer hybrids: synthesis methods, properties and biomedical applications,” Meth. Microbiol, vol. 46, p. 227, 2019.Google Scholar
Liu, S., Yua, B., Wanga, S., Shena, Y., and Conga, H., “Preparation, surface functionalization and application of Fe3O4 magnetic nanoparticles,” Adv. Colloid Interf. Sci., vol. 281, p. 102165, 2020.Google Scholar
Xiao, X., Wang, J., Carlisle, J. A., et al., “In vitro and in vivo evaluation of ultrananocrystalline diamond for coating of implantable retinal microchips,” J. Biomed. Mater., vol. 77B, p. 273, 2006.Google Scholar
Weiland, J. D., Liu, W., and Humayun, M. S., “Retinal prothesis,” Ann. Rev. Biomed. Eng., vol. 7, p. 361, 2005.Google Scholar
Auciello, O., Gurman, P., Berra, A., Saravia, M., and Zysler, R., “Ultrananocrystalline diamond (UNCD) films for ophthalmological applications,” in Diamond-Based Materials for Biomedical Applications, Narayan, R., Ed. Cambridge: Woodhead Publishing, p. 150, 2013.Google Scholar

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