Abstract

This chapter focuses on the fabrication and characterization of a microcage for biopsy applications. A microcage based on a free-standing film could be opened/closed through substrate heating with a maximum temperature of 90 °C, or Joule heating with a power less than 5 mW and a maximum response frequency of 300 Hz. A TiNi/diamond-like-carbon (DLC) microcage has been designed, analyzed, fabricated and characterized. The bimorph structure is composed of a top layer of TiNi film and a bottom layer of highly compressively stressed DLC for upward bending once it is released from the substrate. The fingers of the microcage quickly close through the shape memory effect once the temperature reaches the austenite transformation point to execute the gripping action. Opening of the microcage is realized by either decreasing the temperature to make use of the martensitic transformation or further increasing the temperature to use the bimorph thermal effect. The biocompatibility of both the TiNi and DLC films has been investigated using a cell-culture method.

Introduction

The wireless capsule endoscope (WCE) is a new diagnostic tool for searching for the cause of obscure gastrointestinal bleeding. A WCE contains video imaging, self-illumination, image transmission modules and a battery [1, 2]. The indwelling camera takes images and uses wireless radio transmission to send the images to a receiving recorder device that the patient wears around the waist. However, there are two drawbacks for the current WCE: (1) lack of ability for biopsy; and (2) difficulty in identifying the precise location of the pathology. Without tissue diagnosis, it is often difficult to differentiate inflammatory lesions from tumour infiltration.