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Chapter 4 - Chromosomes in Early Human Embryo Development: Incidence of Chromosomal Abnormalities, Underlying Mechanisms, and Consequences for Diagnosis and Development

Published online by Cambridge University Press:  15 December 2022

By
Esther B. Baart ,
Effrosyni A. Chavli  and
Diane Van Opstal
Edited by
Stéphane Viville  and
Karen D. Sermon
Stéphane Viville
Affiliation:
Laboratoire de Génétique Médicale de Strasbourg and Laboratoire de diagnostic génétique, Strasbourg
Karen D. Sermon
Affiliation:
Reproduction and Genetics Research Group, Vrije Universiteit Brussel
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Summary

Reproduction in humans is considered to be a relatively inefficient process, as the chance of achieving a spontaneous pregnancy after timed intercourse is only approximately 30%. This is much lower than the 70–90% estimated for other species, such as the rhesus monkey, the captive baboon, or rodents and rabbits. The inefficiency of human reproduction is mainly explained by the high incidence of preclinical losses, an estimated 40–60% of all conceptions. Early pregnancy loss is mainly explained due to the occurrence of chromosome abnormalities, which have been identified in most spontaneous abortion samples investigated.

Type
Chapter
Information
Textbook of Human Reproductive Genetics , pp. 48 - 67
Publisher: Cambridge University Press
Print publication year: 2023

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