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Published online by Cambridge University Press: 19 October 2021
• Three neurotransmitters involved in the regulation of depressive symptomatology were discussed: serotonin, norepinephrine and dopamine
• Circuits include pathways extensively traveled by 5HT, NE and DA
• Various genes are risk factors for depression
• Depression can often be treatment-resistant, resulting in the need for several different drug combinations prior to achieving response and full remission
• There are currently many classes of antidepressants available, with SSRIs, SNRIs and NDRIs most often considered first-line treatment options
• Augmentation of these first-line treatments can be selected by using a symptom-based strategy; that is, choose treatments most likely to reduce each individual patient's specific symptoms based upon the underlying neurobiological ratio-nale for these symptoms
• Several new treatments for depression are on the horizon
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