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Chapter 11 - Sleep Disorders and Psychiatry

Published online by Cambridge University Press:  04 April 2024

David Kingdon
Affiliation:
University of Southampton
Paul Rowlands
Affiliation:
Derbyshire Healthcare NHS foundation Trust
George Stein
Affiliation:
Emeritus of the Princess Royal University Hospital
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Summary

Sleep is one of the great mysteries of human experience. It is a behaviour that is highly preserved throughout the animal kingdom, and it constitutes a third of our existence. It begins before birth and is with us throughout life. For a newborn baby, it is their predominant behaviour and continues to occupy a large proportion of our lives as we age. It has long been suspected that it is essential for good mental and physical health, and in the last century, there has been growing scientific evidence to confirm this suspicion. Yet, we know very little about the functions of sleep and are only just beginning to understand the mechanisms that control it. In the past, it was commonly assumed that sleep had ’a function’, but the more we have come to understand, the clearer it has become that sleep performs multiple functions. Precisely what those functions are is still uncertain, and they may change across the lifespan or possibly even vary across different species. We know that sleep is essential for life and total sleep deprivation for long enough is fatal, and the fact that we spend a third of our lives in this vulnerable state underlines how important sleep must be.

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Publisher: Cambridge University Press
Print publication year: 2024

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References

Bliwise, DL, Scullin, MK. Normal aging. In: Kryger, MH, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 2538.CrossRefGoogle Scholar
Everson, CA, Bergmann, BM, Rechtschaffen, A. Sleep deprivation in the rat: III. total sleep deprivation. Sleep 1989;12(1):1321. pubmed.ncbi.nlm.nih.gov/2928622/ (accessed 7 November 2021).CrossRefGoogle ScholarPubMed
Arrigoni, E, Fuller, PM. An overview of sleep: physiology and neuroanatomy. In: Barkoukis, TJ, Matheson, JK, Ferber, R, et al. (eds.) Therapy in Sleep Medicine. Philadelphia: Elsevier Inc.; 2012: 4361.CrossRefGoogle Scholar
Lee-Chiong, T. Sleep Medicine: Essentials and Review. Oxford: Oxford University Press; 2008.CrossRefGoogle Scholar
van de Castle, RL. Our Dreaming Mind. New York: Ballantine Books; 1995.Google Scholar
Gehrman, PR, Thase, ME, Riemann, D, et al. Depressive disorders. In: Winkelman, J, Plante, DT (eds.) Foundations of Psychiatric Sleep Medicine. Cambridge: Cambridge University Press; 2010: 247–65. www.cambridge.org/core/product/identifier/9780511777493%23c51511-15-2/type/book_part (accessed 14 November 2021).Google Scholar
Plante, DT, Winkelman, JW. Polysomnographic features of medical and psychiatric disorders and their treatments. Sleep Medicine Clinics 2009;4(3):407–19.CrossRefGoogle Scholar
Schilgen, B, Tölle, R. Partial sleep deprivation as therapy for depression. Archives of General Psychiatry 1980;37(3):267–71.Google ScholarPubMed
Landsness, EC, Goldstein, MR, Peterson, MJ, et al. Antidepressant effects of selective slow wave sleep deprivation in major depression: a high-density EEG investigation. Journal of Psychiatric Research 2011;45(8):1019–26.CrossRefGoogle ScholarPubMed
Watson, CJ, Baghdoyan, HA, Lydic, R. Neuropharmacology of sleep and wakefulness: 2012 update. Sleep Medicine Clinics. 2012;7(3):469–86. www.ncbi.nlm.nih.gov/pmc/articles/PMC3496285/ (accessed 8 September 2023).CrossRefGoogle Scholar
McGinty, D, Szymusiak, R. Chapter 7 – Neural control of sleep in mammals. In: Krieger, M, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 6277.CrossRefGoogle Scholar
Borbély, AA, Daan, S, Wirz-Justice, A, et al. The two-process model of sleep regulation: a reappraisal. Journal of Sleep Research 2016;25(2):131–43.CrossRefGoogle ScholarPubMed
Pack, AI, Keenan, BT, Byrne, EM, et al. Chapter 31 – Genetics and Genomic Basis of Sleep Disorders in Humans. In: Krieger, M, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 322–39.Google Scholar
Krauchi, K, Deboer, T. Thermoregulation in sleep and hibernation. In: Krieger, M, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 220–8.Google Scholar
Kosky, C. Sleep investigations. In: Selsick, H (ed.) Sleep Disorders in Psychiatric Patients. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018: 6383. link.springer.com/10.1007/978-3-642-54836-9_4 (accessed 14 March 2019).CrossRefGoogle Scholar
Kubala, AG, Barone Gibbs, B, Buysse, DJ, et al. Field-based measurement of sleep: agreement between six commercial activity monitors and a validated accelerometer. Behavioral Sleep Medicine 2019;18(5):637–52. www.tandfonline.com/doi/abs/10.1080/15402002.2019.1651316 (accessed 15 November 2021).Google Scholar
American Academy of Sleep Medicine. International Classification of Sleep Disorders – Third Edition (ICSD-3). Darien, IL: AASM Resource Library; 2014.Google Scholar
Vgontzas, AN, Fernandez-Mendoza, J, Liao, D, et al. Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder. Sleep Medicine Reviews 2013;17(4):241–54.CrossRefGoogle ScholarPubMed
Katz, D, McHorney, C. The relationship between insomnia and health-related quality of life in patients with chronic illness. The Journal of Family Practice. 2002;51(3):229–35.Google ScholarPubMed
Lichstein, KL, Taylor, DJ, McCrae, CS, et al. Insomnia: epidemiology and risk factors. In: Krieger, M, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 761–8.Google Scholar
Fleming, JAE. Insomnia: epidemiology, subtypes, and relationship to psychiatric disorders. In: Selsick, H (ed.) Sleep Disorders in Psychiatric Patients. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018: 99107. link.springer.com/10.1007/978-3-642-54836-9_6 (accessed 14 March 2019).CrossRefGoogle Scholar
Franzen, PL, Buysse, DJ. Sleep disturbances and depression: risk relationships for subsequent depression and therapeutic implications. Dialogues in Clinical Neuroscience 2008;10(4):473–81.CrossRefGoogle ScholarPubMed
Chang, PP, Ford, DE, Mead, LA, et al. Insomnia in young men and subsequent depression: the Johns Hopkins Precursors Study. American Journal of Epidemiology 1997;146(2):105–14. academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a009241 (accessed 27 December 2017).CrossRefGoogle Scholar
Ong, JC, Arnedt, JT, Gehrman, PR. Insomnia diagnosis, assessment, and evaluation. In: Krieger, M, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 785–93.Google Scholar
Schonmann, Y, Goren, O, Bareket, R, et al. Chronic hypnotic use at 10 years –does the brand matter? European Journal of Clinical Pharmacology 2018;74(12):1623–31. link.springer.com/article/10.1007/s00228-018-2531-4 (accessed 11 May 2021).CrossRefGoogle ScholarPubMed
Roth, T, Walsh, JK, Krystal, A, et al. An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Medicine 2005;6(6):487–95.CrossRefGoogle ScholarPubMed
Roehrs, TA, Randall, S, Harris, E, et al. Twelve months of nightly zolpidem does not lead to dose escalation: a prospective placebo-controlled study. Sleep 2011;34(2):207–12.CrossRefGoogle Scholar
Wilson, S, Anderson, K, Baldwin, D, et al. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: an update. Journal of Psychopharmacology 2019;33(8):923–47.CrossRefGoogle ScholarPubMed
Riemann, D, Perlis, ML. The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies. Sleep Medicine Reviews 2009;13(3):205–14.CrossRefGoogle ScholarPubMed
Roehrs, T, Roth, T. Insomnia pharmacotherapy. Neurotherapeutics 2012;9(4):728. link.springer.com/article/10.1007/s13311-012-0148-3 (accessed 8 September 2023).CrossRefGoogle ScholarPubMed
Howland, RH. Sleep interventions for the treatment of depression. Journal of Psychosocial Nursing and Mental Health Services 2011;49:1720.Google ScholarPubMed
Krystal, A, Fava, M, Rubens, R, et al. Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. Journal of Clinical Sleep Medicine 2007;3(1):4855.Google ScholarPubMed
Jindal, RD. Insomnia in patients with depression: some pathophysiological and treatment considerations. CNS Drugs 2009;23(4):309–29. link.springer.com/article/10.2165/00023210-200923040-00004.CrossRefGoogle ScholarPubMed
Trauer, JM, Qian, MY, Doyle, JS, et al. Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis. Annals of Internal Medicine 2015;163(3):191204.CrossRefGoogle ScholarPubMed
Bathgate, CJ, Edinger, JD, Krystal, AD. Insomnia patients with objective short sleep duration have a blunted response to cognitive behavioral therapy for insomnia. Sleep 2017;40(1).Google ScholarPubMed
Rybarczyk, B, Lund, HG. Comorbid insomnia. Clinics in Sleep Medicine 2018;4(4):571–82. dx.doi.org/10.1016/j.jsmc.2009.07.010.Google Scholar
Edinger, JD, Olsen, MK, Stechuchak, KM, et al. Cognitive behavioral therapy for patients with primary insomnia or insomnia associated predominantly with mixed psychiatric disorders: a randomized clinical trial. Sleep 2009;32(4):499510.CrossRefGoogle ScholarPubMed
Harvey, AG, Soehner, AM, Kaplan, KA, et al. Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: a pilot randomized controlled trial. Journal of Consulting and Clinical Psychology 2015;83(3):564–77. doi.apa.org/getdoi.cfm?doi=10.1037/a0038655 (accessed 14 January 2018).CrossRefGoogle ScholarPubMed
Ulmer, CS, Edinger, JD, Calhoun, PS. A multi-component cognitive-behavioral intervention for sleep disturbance in Veterans with PTSD: A pilot study. Journal of Clinical Sleep Medicine 2011;7(1):5768.CrossRefGoogle ScholarPubMed
Myers, E, Startup, H, Freeman, D. Cognitive behavioural treatment of insomnia in individuals with persistent persecutory delusions: a pilot trial. Journal of Behavior Therapy and Experimental Psychiatry 2011;42(3):330–6.CrossRefGoogle ScholarPubMed
Cunningham, JEA, Shapiro, CM. Cognitive behavioural therapy for insomnia (CBT-I) to treat depression: a systematic review. Journal of Psychosomatic Research 2018;106:112.CrossRefGoogle ScholarPubMed
Blom, K, Jernelöv, S, Rück, C, et al. Three-year follow-up comparing cognitive behavioral therapy for depression to cognitive behavioral therapy for insomnia, for patients with both diagnoses. Sleep 2017;40(8).CrossRefGoogle ScholarPubMed
Cogen, JD, Loghmanee, DA. Sleep related movement disorders. In: Sheldon, SH, Ferber, R, Kryger, MH, et al. (eds.) Principles and Practice of Pediatric Sleep Medicine. 2nd ed. London: Elsevier Saunders; 2014: 333–6.Google Scholar
Allen, RP. Restless legs syndrome/Willis Ekbom disease: evaluation and treatment. International Review of Psychiatry 2014;26(2):248–62.CrossRefGoogle ScholarPubMed
Hornyak, M, Scholz, H, Kohnen, R, et al. What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications. Sleep Medicine Reviews 2014;18(2):153–64. dx.doi.org/10.1016/j.smrv.2013.03.004.Google ScholarPubMed
Durmer, JS. Restless legs syndrome, periodic leg movements and periodic limb movement disorder. In: Sheldon, SH, Ferber, R, Kryger, MH, et al. (eds.) Principles and Practice of Pediatric Sleep Medicine, 2nd ed. London: Elsevier Saunders; 2014: 337–50.Google Scholar
Becker, PM. The biopsychosocial effects of restless legs syndrome (RLS). Neuropsychiatric Disease and Treatment 2006;2(4):505–12.CrossRefGoogle ScholarPubMed
Castaño-De La Mota, C, Moreno-Acero, N, Losada-Del Pozo, R, et al. Restless legs syndrome in patients diagnosed with attention deficit hyperactivity disorder. Revista de Neurologia 2017;64(7):299304. europepmc.org/article/med/28345734 (accessed 24 May 2021).Google ScholarPubMed
Ferri, R, Lanuzza, B, Cosentino, FII, et al. A single question for the rapid screening of restless legs syndrome in the neurological clinical practice. European Journal of Neurology 2007;14(9):1016–21.CrossRefGoogle ScholarPubMed
Klingelhoefer, L, Bhattacharya, K, Reichmann, H. Restless legs syndrome. Clinical Medicine Journal 2016;16(4):379–82.Google ScholarPubMed
Balaban, H, Yildiz, OK, Çil, G, et al. Serum 25-hydroxyvitamin D levels in restless legs syndrome patients. Sleep Medicine 2012;13(7):953–7.CrossRefGoogle ScholarPubMed
Hornyak, M, Scholz, H, Kohnen, R, et al. What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications. Sleep Medicine Reviews 2014;18(2):153–64.Google ScholarPubMed
Deak, MC, Winkelman, JW. The pharmacologic management of restless legs syndrome and periodic leg movement disorder. Sleep Medicine Clinics 2010;5(4):675–87. linkinghub.elsevier.com/retrieve/pii/S1556407X10000913 (accessed 29 March 2013).CrossRefGoogle Scholar
Garcia-borreguero, D, Silber, MH, Winkelman, JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Medicine 2016;21:111. dx.doi.org/10.1016/j.sleep.2016.01.017.CrossRefGoogle ScholarPubMed
Amos, LB, Grekowicz, ML, Kuhn, EM, et al. Treatment of pediatric restless legs syndrome. Clinical Pediatrics 2014;53(4):331–6. journals.sagepub.com/doi/abs/10.1177/0009922813507997 (accessed 24 May 2021).CrossRefGoogle ScholarPubMed
Selsick, H, O’Regan, D. Sleep disorders in psychiatry. BJPsych Advances 2018;24(4):273–83. www.cambridge.org/core/product/identifier/S2056467818000087/type/journal_article (accessed 3 December 2018).CrossRefGoogle Scholar
Kripke, DF, Rex, KM, Ancoli-Israel, S, et al. Delayed sleep phase cases and controls. Journal of Circadian Rhythms 2008;6:114.CrossRefGoogle ScholarPubMed
Wirz-Justice, A. Diurnal variation of depressive symptoms. Dialogues in Clinical Neuroscience 2008;10(3):337–43. www.tandfonline.com/doi/full/10.31887/DCNS.2008.10.3/awjustice.CrossRefGoogle ScholarPubMed
Borodkin, K, Dagan, Y. Circadian rhythm disorders. In: Winkelman, J, Plante, D (eds.) Foundations of Psychiatric Sleep Medicine. Cambridge: Cambridge University Press; 2010: 186202.CrossRefGoogle Scholar
Poon, YPYP, Kan, CK, Yeung, WF, et al. Delayed sleep-wake phase disorder and delayed sleep-wake phase in schizophrenia: clinical and functional correlates. Schizophrenia Research 2018;202(2018):412–3. doi.org/10.1016/j.schres.2018.06.057.CrossRefGoogle ScholarPubMed
Morgenthaler, TI, Lee-Chiong, T, Alessi, C, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders: an American Academy of Sleep Medicine report. Sleep 2007;30(11):1445–59.CrossRefGoogle ScholarPubMed
van Geijlswijk, IM, Korzilius, HPLM, Smits, MG. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 2010;33(12):1605–14.CrossRefGoogle ScholarPubMed
Dodson, ER, Zee, PC. Therapeutics for circadian rhythm sleep disorders. Sleep Medicine Clinics 2010;5(4):701–15. www.ncbi.nlm.nih.gov/pmc/articles/PMC3020104/ (accessed 8 September 2023).CrossRefGoogle ScholarPubMed
Leschziner, G. Nocturnal Brain: Tales of Nightmares and Neuroscience. London: Simon & Schuster UK; 2019.Google Scholar
Eriksson, S, Walker, M. Non-REM parasomnias and REM sleep behaviour disorder. In: Selsick, H (ed.) Sleep Disorders in Psychiatric Patients. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018: 263–76. link.springer.com/10.1007/978-3-642-54836-9_14 (accessed 14 March 2019).Google Scholar
Hurwitz, TD, Schenck, CH. Parasomnias. In: Winkelman, J, Plante, D (eds.) Foundations of Psychiatric Sleep Medicine. Cambridge: Cambridge University Press; 2010: 160–85.Google Scholar
Johnson, CM, Lerner, M. Amelioration of infant sleep disturbances: II. effects of scheduled awakenings by compliant parents. Infant Mental Health Journal 1985;6(1):2130. onlinelibrary.wiley.com/doi/abs/10.1002/1097-0355%28198521%296%3A1%3C21%3A%3AAID-IMHJ2280060105%3E3.0.CO%3B2-Q (accessed 26 May 2021).3.0.CO;2-Q>CrossRefGoogle Scholar
Bruni, O, Ferri, R, Miano, S, et al. L -5-Hydroxytryptophan treatment of sleep terrors in children. European Journal of Pediatrics 2004;163(7):402–7. link.springer.com/article/10.1007/s00431-004-1444-7 (accessed 26 May 2021).CrossRefGoogle ScholarPubMed
Aurora, RN, Zak, RS, Auerbach, SH, et al. Best practice guide for the treatment of nightmare disorder in adults. Journal of Clinical Sleep Medicine 2010;6(4):389401.Google ScholarPubMed
Arnulf, I. Nightmares and dream disturbances. In: Kryger, MH, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine, 6th ed. Philadelphia: Elsevier; 2017: 1002–10.Google Scholar
Bernert, RA, Nadorff, MR. Sleep disturbances and suicide risk. Sleep Medicine Clinics 2015;10(1):35–9. dx.doi.org/10.1016/j.jsmc.2014.11.004.CrossRefGoogle ScholarPubMed
Sjöström, N, Waern, M, Hetta, J. Nightmares and sleep disturbances in relation to suicidality in suicide attempters. Sleep 2007;30(1):91–5.CrossRefGoogle ScholarPubMed
Bahammam, AS, Almeneessier, AS. Dreams and nightmares in patients with obstructive sleep apnea: a review. Frontiers in Neurology 2019;10:1127.CrossRefGoogle ScholarPubMed
Iranzo, A, Santamaria, J, Tolosa, E. The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Medicine Reviews 2009;13(6):385401. dx.doi.org/10.1016/j.smrv.2008.11.003.CrossRefGoogle ScholarPubMed
Schenck, CH, Boeve, BF, Mahowald, MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Medicine 2013;14(8):744–8. www.sciencedirect.com/science/article/pii/S1389945712003814 (accessed 20 August 2021).CrossRefGoogle ScholarPubMed
Postuma, RB, Arnulf, I, Hogl, B, et al. A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study. Movement Disorders 2012;27(7):913–6.Google ScholarPubMed
Aurora, RN, Zak, RS, Maganti, RK, et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). Journal of Clinical Sleep Medicine 2010;6(1):8595.Google ScholarPubMed
Sharpless, BA, Doghramji, K. Sleep Paralysis: Historical, Psychological, and Medical Perspectives. Oxford: Oxford University Press; 2015.CrossRefGoogle Scholar
Sharpless, BA. A clinician’s guide to recurrent isolated sleep paralysis. Neuropsychiatric Disease and Treatment 2016;12:1761–7. www.dovepress.com/a-clinicianrsquos-guide-to-recurrent-isolated-sleep-paralysis-peer-reviewed-article-NDT (accessed 20 August 2021).CrossRefGoogle ScholarPubMed
Lopresti, AL, Drummond, PD. Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2013 Aug 1;45:92–9.Google Scholar
Jokic, R. Obstructive sleep apnoea. In: Selsick, H (ed.) Sleep Disorders in Psychiatric Patients. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018: 213–38. link.springer.com/10.1007/978-3-642-54836-9_12Google Scholar
Krysta, K, Bratek, A, Zawada, K, et al. Cognitive deficits in adults with obstructive sleep apnea compared to children and adolescents. Journal of Neural Transmission 2017;124(Suppl 1):187201.CrossRefGoogle ScholarPubMed
Dunietz, GL, Chervin, RD, Burke, JF, et al. Obstructive sleep apnea treatment and dementia risk in older adults. Sleep 2021;44(9).CrossRefGoogle ScholarPubMed
Morrell, M. Changes in brain morphology associated with obstructive sleep apnea. Sleep Medicine 2003;4(5):451–4. linkinghub.elsevier.com/retrieve/pii/S138994570300159X (accessed 4 June 2014).CrossRefGoogle ScholarPubMed
Pang, KP, Gourin, CG, Terris, DJ. A comparison of polysomnography and the WatchPAT in the diagnosis of obstructive sleep apnea. Otolaryngology – Head and Neck Surgery 2007;137(4):665–8. journals.sagepub.com/doi/abs/10.1016/j.otohns.2007.03.015 (accessed 18 November 2021).Google ScholarPubMed
Shahid, A, Shen, J, Shapiro, CM. Central hypersomnias. In: Selsick, H (ed.) Sleep Disorders in Psychiatric Patients. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018: 239–62. link.springer.com/10.1007/978-3-642-54836-9_13 (accessed 4 March 2019).Google Scholar
Murru, A, Guiso, G, Barbuti, M, et al. The implications of hypersomnia in the context of major depression: results from a large, international, observational study. European Neuropsychopharmacology 2019;29(4):471–81.CrossRefGoogle ScholarPubMed
Fortuyn, HAD, Lappenschaar, MA, Furer, JW, et al. Anxiety and mood disorders in narcolepsy: a case-control study. General Hospital Psychiatry 2010;32(1):4956.CrossRefGoogle ScholarPubMed
Cao, MT, Guilleminault, C. Narcolepsy: diagnosis and management. In: Krieger, M, Roth, T, Dement, WC (eds.) Principles and Practice of Sleep Medicine. 6th ed. Philadelphia: Elsevier; 2017: 873–82.Google Scholar
Dauvilliers, Y, Bassetti, C, Lammers, GJ, et al. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. The Lancet Neurology 2013;12(11):1068–75.CrossRefGoogle ScholarPubMed
Subedi, R, Singh, R, Thakur, RK, et al. Efficacy and safety of solriamfetol for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea: a systematic review and meta-analysis of clinical trials. Sleep Medicine 2020;75:510–21.CrossRefGoogle ScholarPubMed

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