Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-29T09:17:37.018Z Has data issue: false hasContentIssue false

Chapter 6.1 - Anxiety Disorders

Published online by Cambridge University Press:  04 April 2024

David Kingdon
Affiliation:
University of Southampton
Paul Rowlands
Affiliation:
Derbyshire Healthcare NHS foundation Trust
George Stein
Affiliation:
Emeritus of the Princess Royal University Hospital
Get access

Summary

Anxiety symptoms and anxiety disorders are common in community settings and primary and secondary medical care. Anxiety symptoms are often mild and only transient, but many people are troubled by severe symptoms that cause both considerable personal distress and a marked impairment in social and occupational function. The principal anxiety disorders are currently considered to comprise panic disorder, generalised anxiety disorder, social anxiety disorder, agoraphobia, specific phobias, separation anxiety disorder and selective mutism. Additional conditions (not considered further here) include substance/medication-induced anxiety disorder, anxiety disorder due to another medical condition, other specified anxiety disorder and unspecified anxiety disorder. Together, anxiety disorders constitute the most frequent mental disorders, with an estimated 12-month prevalence of approximately 10–14 per cent.

Although the societal impact of anxiety disorders is substantial, many of those who could benefit from psychological or pharmacological treatment are neither recognised nor treated. Recognition relies on maintaining a keen awareness of the psychological and physical symptoms of anxiety disorders, and accurate diagnosis rests on identifying the pathognomonic features of specific conditions.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Penninx, BW, Pine, DS, Holmes, EA, Reif, A. Anxiety disorders. Lancet 2021;397: 914–27.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: APA; 2013.Google Scholar
Solis, EC, van Hemert, AM, Carlier, IVE, et al. The 9-year clinical course of depressive and anxiety disorders: new NESDA findings. Journal of Affective Disorders 2021;295:1269–79.CrossRefGoogle ScholarPubMed
World Health Organization. ICD-11: International Classification of Diseases, 11th revision. Geneva: World Health Organization, 2019.Google Scholar
Ruscio, AM, Hallion, LS, Lim, CCW, et al. Cross-sectional comparison of the epidemiology of DSM-5 generalized anxiety disorder across the globe. JAMA Psychiatry 2017;74(5):465–75.CrossRefGoogle ScholarPubMed
Culpepper, L. Generalized anxiety disorder and medical illness. Journal of Clinical Psychiatry 2009;70(Suppl 2):20–4.Google ScholarPubMed
Kessler, RC, Chiu, WT, Jin, R, et al. The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Archives of General Psychiatry 2006;63(4):415–24.CrossRefGoogle ScholarPubMed
de Jonge, P, Roest, AM, Lim, CC, et al. Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys. Depression and Anxiety 2016;33(12):1155–77.CrossRefGoogle ScholarPubMed
Alonso, J, Mortier, P, Auerbach, RP, et al. Severe role impairment associated with mental disorders: results of the WHO World Mental Health Surveys International College Student Project. Depression and Anxiety 2018;35(9):802–14.CrossRefGoogle ScholarPubMed
Albert, CM, Chae, CU, Rexrode, KM, et al. Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women. Circulation 2005;111(4):480–7.CrossRefGoogle ScholarPubMed
Stein, DJ, Lim, CCW, Roest, AM, et al. The cross-national epidemiology of social anxiety disorder: data from the World Mental Health Survey Initiative. BMC Medicine 2017;15(1):143.CrossRefGoogle ScholarPubMed
Shear, K, Jin, R, Ruscio, AM, et al. Prevalence and correlates of estimated DSM-IV child and adult separation anxiety disorder in the National Comorbidity Survey Replication. American Journal of Psychiatry 2006;163(6):1074–83.CrossRefGoogle ScholarPubMed
Silove, D, Alonso, J, Bromet, E, et al. Pediatric-onset and adult-onset separation anxiety disorder across countries in the World Mental Health Survey. American Journal of Psychiatry 2015;172(7):647–56.CrossRefGoogle ScholarPubMed
Solmi, M, Radua, J, Olivola, M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Molecular Psychiatry 2022;27(1):281–95.CrossRefGoogle ScholarPubMed
Gottschalk, MG, Domschke, K. Genetics of generalized anxiety disorder and related traits. Dialogues in Clinical Neuroscience 2017;19(2):159–68.CrossRefGoogle ScholarPubMed
Safren, SA, Gershuny, BS, Marzol, P, et al. History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder. Journal of Nervous and Mental Disease 2002;190(7):453–6.CrossRefGoogle ScholarPubMed
Bandoli, G, Campbell-Sills, L, Kessler, RC, et al. Childhood adversity, adult stress, and the risk of major depression or generalized anxiety disorder in US soldiers: a test of the stress sensitization hypothesis. Psychological Medicine 2017;47(13):2379–92.CrossRefGoogle ScholarPubMed
Koerner, K, McEvoy, P, et al. Cognitive-behavioral models of generalized anxiety disorder (GAD): towards a synthesis. In: Gerlach, AL, Gloster, AT (eds.) Generalized Anxiety Disorder and Worrying: A Comprehensive Handbook for Clinicians and Researchers. Hoboken, NJ: John Wiley & Sons; 2021: 117–50.Google Scholar
Goodwin, H, Yiend, J, Hirsch, CR. Generalized anxiety disorder, worry and attention to threat: a systematic review. Clinical Psychology Review 2017;54:107–22.CrossRefGoogle ScholarPubMed
Sutherland-Stolting, A, Liao, B, Kraus, K, et al. Pathogenesis of generalized anxiety disorder. In: Simon, NM, Hollander, E, Rothbaum, BO, Stein, DJ (eds) Textbook of Anxiety, Trauma and OCD-Related Disorders (third edition). Washington, D.C.: American Psychiatric Association Publishing; 2020:181–96.Google Scholar
Wemmie, JA, Taugher, RJ, Kreple, CJ. Acid-sensing ion channels in pain and disease. Nature Reviews. Neuroscience 2013;14(7):461–71.CrossRefGoogle ScholarPubMed
Costello, H, Gould, RL, Abrol, E, et al. Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder. BMJ Open 2019;9(7):e027925.CrossRefGoogle ScholarPubMed
Schienle, A, Wabnegger A. Structural and functional neuroanatomy of generalized anxiety disorder. In: Gerlach, AL, Gloster, AT (eds.) Generalized Anxiety Disorder and Worrying: A Comprehensive Handbook for Clinicians and Researchers. Hoboken, NJ: John Wiley & Sons; 2021: 151–71.Google Scholar
Goossen, B, van der Starre, J, van der Heiden, C. A review of neuroimaging studies in generalized anxiety disorder: “So where do we stand?”. Journal of Neural Transmission (Vienna) 2019;126(9):1203–16.Google Scholar
Webler, RD, Coplan, JD. Pathogenesis of panic disorder. In: Simon, NM, Hollander, E, Rothbaum, BO, et al. (eds.) Textbook of Anxiety, Trauma and OCD-Related Disorders, 3rd ed. Washington, DC: American Psychiatric Association Publishing; 2020:373–84.Google Scholar
Zwanzger, P, Domschke, K, Bradwejn, J. Neuronal network of panic disorder: the role of the neuropeptide cholecystokinin. Depression and Anxiety 2012;29(9):762–74.CrossRefGoogle ScholarPubMed
Rehfeld, JF. Cholecystokinin and panic disorder: reflections on the history and some unsolved questions. Molecules 2021;26(18):5657.CrossRefGoogle ScholarPubMed
Klein, DF. False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Archives of General Psychiatry 1993;50(4):306–17.Google ScholarPubMed
Feinstein, JS, Gould, D, Khalsa, SS. Amygdala-driven apnea and the chemoreceptive origin of anxiety. Biological Psychology 2022;170:108305.CrossRefGoogle ScholarPubMed
Dresler, T, Guhn, A, Tupak, SV, et al. Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder. Journal of Neural Transmission (Vienna) 2013;120(1):329.CrossRefGoogle ScholarPubMed
Menon, V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends in Cognitive Sciences 2011;15(10):483506.CrossRefGoogle ScholarPubMed
Manfro, GG, Otto, MW, McArdle, ET, et al. Relationship of antecedent stressful life events to childhood and family history of anxiety and the course of panic disorder. Journal of Affective Disorders 1996;41(2):135–9.CrossRefGoogle ScholarPubMed
Lissek, S. Toward an account of clinical anxiety predicated on basic, neurally mapped mechanisms of Pavlovian fear-learning: the case for conditioned overgeneralization. Depression and Anxiety 2012;29(4):257–63.CrossRefGoogle ScholarPubMed
Bas-Hoogendam, J, Roelofs, E, Westenberg, P, et al. Pathogenesis of social anxiety disorder. In: Simon, N, Hollander, E, Rothbaum, BO, et al. (eds.) Textbook of Anxiety, Trauma, and OCD-related Disorders. Washington, DC: The American Psychiatric Association Publishing; 2020: 429–44.Google Scholar
Scaini, S, Belotti, R, Ogliari, A. Genetic and environmental contributions to social anxiety across different ages: a meta-analytic approach to twin data. Journal of Anxiety Disorders 2014;28(7):650–6.CrossRefGoogle Scholar
Neumann, ID, Slattery, DA. Oxytocin in general anxiety and social fear: a translational approach. Biological Psychiatry 2016;79(3):213–21.CrossRefGoogle ScholarPubMed
Bandelow, B, Baldwin, D, Abelli, M, et al. Biological markers for anxiety disorders, OCD and PTSD: a consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition. The World Journal of Biological Psychiatry 2017;18(3):162214.CrossRefGoogle ScholarPubMed
Bruehl, AB, Delsignore, A, Komossa, K, et al. Neuroimaging in social anxiety disorder – a meta-analytic review resulting in a new neurofunctional model. Neuroscience & Biobehavioral Reviews 2014;47:260–80.Google Scholar
Wong, QJJ, Rapee, RM. The aetiology and maintenance of social anxiety disorder: a synthesis of complimentary theoretical models and formulation of a new integrated model. Journal of Affective Disorders 2016;203:84100.CrossRefGoogle ScholarPubMed
Scaini, S, Ogliari, A, Eley, TC, et al. Genetic and environmental contributions to separation anxiety: a meta-analytic approach to twin data. Depression and Anxiety 2012;29(9):754–61.CrossRefGoogle ScholarPubMed
Bartholomew, K, Horowitz, LM. Attachment styles among young adults: a test of a four-category model. Journal of Personality and Social Psychology 1991;61(2):226–44.CrossRefGoogle ScholarPubMed
Greenberg, MT. Attachment and psychopathology in childhood. In: Cassidy, J, Shaver, PR (eds.) Handbook of Attachment: Theory, Research, and Clinical Applications. New York: Guilford Press; 1999: 469–96.Google Scholar
Pini, S, Abelli, M, Troisi, A, et al. The relationships among separation anxiety disorder, adult attachment style and agoraphobia in patients with panic disorder. Journal of Anxiety Disorders 2014;28(8):741–6.CrossRefGoogle ScholarPubMed
Pini, S, Abelli, M, Costa, B, et al. Relationship of behavioral inhibition to separation anxiety in a sample (N = 377) of adult individuals with mood and anxiety disorders. Comprehensive Psychiatry 2022;116:152326.CrossRefGoogle Scholar
Boelen, PA, Reijntjes, A, Carleton, RN. Intolerance of uncertainty and adult separation anxiety. Cognitive Behaviour Therapy 2014;43(2):133–44.CrossRefGoogle ScholarPubMed
Atlı, O, Bayın, M, Alkın, T. Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. Journal of Affective Disorders 2012;141(2–3):315–23.CrossRefGoogle ScholarPubMed
Roberson-Nay, R, Eaves, LJ, Hettema, JM, et al. Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. Depression and Anxiety 2012;29(4):320–7.CrossRefGoogle Scholar
Crockford, C, Deschner, T, Ziegler, TE, et al. Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review. Frontiers in Behavioural Neuroscience 2014;8:68.CrossRefGoogle ScholarPubMed
Lebowitz, ER, Leckman, JF, Feldman, R, et al. Salivary oxytocin in clinically anxious youth: associations with separation anxiety and family accommodation. Psychoneuroendocrinology 2016;65:3543.CrossRefGoogle ScholarPubMed
Costa, B, Pini, S, Martini, C, et al. Mutation analysis of oxytocin gene in individuals with adult separation anxiety. Psychiatry Research 2009;168(2):8793.CrossRefGoogle ScholarPubMed
Gordon, I, Zagoory-Sharon, O, Schneiderman, I, et al. Oxytocin and cortisol in romantically unattached young adults: associations with bonding and psychological distress. Psychophysiology 2008;45(3):349–52.CrossRefGoogle ScholarPubMed
Baldwin, DS, Anderson, IM, Nutt, DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. Journal of Psychopharmacology 2014;28(5):403–39.CrossRefGoogle ScholarPubMed
Bandelow, B, Reitt, M, Röver, C, et al. Efficacy of treatments for anxiety disorders: a meta-analysis. International Clinical Psychopharmacology 2015;30(4):183–92.CrossRefGoogle ScholarPubMed
Batelaan, NM, Bosman, RC, Muntingh, A, et al. Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials. BMJ 2017;358:j3927.CrossRefGoogle ScholarPubMed
Stein, DJ, Craske, MG, Rothbaum, BO, et al. The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management. World Psychiatry 2021;20(3):336–56.CrossRefGoogle ScholarPubMed
Baldwin, DS, Aitchison, K, Bateson, A, et al. Benzodiazepines: risks and benefits. A reconsideration. Journal of Psychopharmacology 2013;27(11):967–71.CrossRefGoogle ScholarPubMed
Silberman, E, Balon, R, Starcevic, V, et al. Benzodiazepines: it’s time to return to the evidence. British Journal of Psychiatry 2021;218(3):125–27.CrossRefGoogle ScholarPubMed
Muscatello, MR, Spina, E, Bandelow, B, et al. Clinically relevant drug interactions in anxiety disorders. Human Psychopharmacology 2012;27(3):239–53.CrossRefGoogle ScholarPubMed
Gomez, AF, Barthel, AL, Hofmann, SG. Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review. Expert Opinion on Pharmacotherapy 2018;19(8):883–94.CrossRefGoogle ScholarPubMed
Barker, MJ, Greenwood, KM, Jackson, M, et al. Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis. Archives of Clinical Neuropsychology 2004;19(3):437–54.CrossRefGoogle ScholarPubMed
Baldwin, DS. Clinical management of withdrawal from benzodiazepine anxiolytic and hypnotic medications. Addiction 2022;117(5):1472–82.CrossRefGoogle ScholarPubMed
Taylor, S, Annand, F, Burkinshaw, P, et al. Dependence and Withdrawal Associated with Some Prescribed Medicines. London: Public Health England; 2019.Google Scholar
Sirdifield, C, Chipchase, SY, Owen, S, et al. A systematic review and meta-synthesis of patients’ experiences and perceptions of seeking and using benzodiazepines and Z-drugs: towards safer prescribing. Patient 2017;10(1):115.CrossRefGoogle ScholarPubMed
Parr, JM, Kavanagh, DJ, Cahill, L, et al. Effectiveness of current treatment approaches for benzodiazepine discontinuation: a meta-analysis. Addiction 2009;104(1):1324.CrossRefGoogle ScholarPubMed
Gallo, AT, Hulse, G. Pharmacological uses of flumazenil in benzodiazepine use disorders: a systematic review of limited data. Journal of Psychopharmacology 2021;35(3):211–20.CrossRefGoogle ScholarPubMed
Mugunthan, K, McGuire, T, Glasziou, P. Minimal interventions to decrease long-term use of benzodiazepines in primary care: a systematic review and meta-analysis. British Journal of General Practice 2011;61(590):e573–8.CrossRefGoogle ScholarPubMed
Dolphin, AC. Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. Journal of Physiology 2016;594(19):5369–90.CrossRefGoogle ScholarPubMed
Calandre, EP, Rico-Villademoros, F, Slim, M. Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use. Expert Review of Neurotherapeutics 2016;16(11):1263–77.CrossRefGoogle ScholarPubMed
Berlin, RK, Butler, PM, Perloff, MD. Gabapentin therapy in psychiatric disorders: a systematic review. Primary Care Companion for CNS Disorders 2015;17(5).Google ScholarPubMed
Ahmed, S, Bachu, R, Kotapati, P, et al. Use of gabapentin in the treatment of substance use and psychiatric disorders: a systematic review. Frontiers in Psychiatry 2019;10:228.CrossRefGoogle ScholarPubMed
Baldwin, DS, den Boer, JA, Lyndon, G, et al. Efficacy and safety of pregabalin in generalised anxiety disorder: a critical review of the literature. Journal of Psychopharmacology 2015;29(10):1047–60.CrossRefGoogle ScholarPubMed
Freynhagen, R, Backonja, M, Schug, S, et al. Pregabalin for the treatment of drug and alcohol withdrawal symptoms: a comprehensive review. CNS Drugs 2016;30(12):1191–200.CrossRefGoogle ScholarPubMed
Evoy, KE, Sadrameli, S, Contreras, J, et al. Abuse and misuse of pregabalin and gabapentin: a systematic review Update. Drugs 2021;81(1):125–56.Google ScholarPubMed
Smith, RV, Havens, JR, Walsh, SL. Gabapentin misuse, abuse and diversion: a systematic review. Addiction 2016;111(7): 1160–74.CrossRefGoogle ScholarPubMed
Hägg, S, Jönsson, AK, Ahlner, J. Current evidence on abuse and misuse of gabapentinoids. Drug Safety 2020;43(12):1235–54.CrossRefGoogle ScholarPubMed
Baldwin, DS, Masdrakis, V. Non-prescribed use of gabapentinoids: mechanisms, predisposing factors, associated hazards and clinical management. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology 2022;63:68.CrossRefGoogle ScholarPubMed
Chessick, CA, Allen, MH, Thase, M, et al. Azapirones for generalized anxiety disorder. Cochrane Database of Systematic Reviews 2006;2006(3):CD006115.Google ScholarPubMed
Loane, C, Politis, M. Buspirone: what is it all about? Brain Research 2012;1461:111–8.CrossRefGoogle ScholarPubMed
Turner, P, Granville-Grossman, KL. Effect of adrenergic receptor blockade of the tachycardia of thyrotoxicosis and anxiety state. Lancet 1965;2(7426):1316–8.Google ScholarPubMed
Steenen, SA, van Wijk, AJ, van der Heijden, GJ, et al. Propranolol for the treatment of anxiety disorders: systematic review and meta-analysis. Journal of Psychopharmacology 2016;30(2):128–39.CrossRefGoogle ScholarPubMed
Bandelow, B, Allgulander, C, Baldwin, DS, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders. The World Journal of Biological Psychiatry 2023;24(2):79117.CrossRefGoogle ScholarPubMed
Feltner, D, Wittchen, HU, Kavoussi, R, et al. Long-term efficacy of pregabalin in generalized anxiety disorder. Internation Clinical Psychopharmacology 2008;23(1):1828.CrossRefGoogle ScholarPubMed
Baldwin, DS, Amaro, HJF. Prescription of valproate-containing medicines in women of childbearing potential who have psychiatric disorders: is it worth the risk? CNS Drugs 2020;34(2):163–69.CrossRefGoogle ScholarPubMed
Kennerley, H. Overcoming Anxiety: A Self-Help Guide Using Cognitive Behavioural Techniques. London: Robinson; 2014.Google Scholar
Willson, R, Branch, R. Cognitive Behavioural Therapy for Dummies. Chichester: John Wiley & Sons; 2019.Google Scholar
Chen, TR, Huang, HC, Hsu, JH, et al. Pharmacological and psychological interventions for generalized anxiety disorder in adults: a network meta-analysis. Journal of Psychiatric Research 2019;118:7383.CrossRefGoogle ScholarPubMed
Herring, MP, Jacob, ML, Suveg, C, et al. Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. Psychotherapy and Psychosomatics 2012;81(1):21–8.CrossRefGoogle ScholarPubMed
Versiani, M, Cassano, G, Perugi, G, et al. Reboxetine, a selective norepinephrine reuptake inhibitor, is an effective and well-tolerated treatment for panic disorder. Journal of Clinical Psychiatry 2002;63(1):31–7.Google ScholarPubMed
Bandelow, B, Stein, DJ, Dolberg, OT, et al. Improvement of quality of life in panic disorder with escitalopram, citalopram, or placebo. Pharmacopsychiatry 2007;40(4):152–6.CrossRefGoogle ScholarPubMed
Quagliato, LA, Cosci, F, Shader, RI, et al. Selective serotonin reuptake inhibitors and benzodiazepines in panic disorder: a meta-analysis of common side effects in acute treatment. Journal of Psychopharmacology 2019;33(11):1340–51.CrossRefGoogle ScholarPubMed
Chawla, N, Anothaisintawee, T, Charoenrungrueangchai, K, et al. Drug treatment for panic disorder with or without agoraphobia: systematic review and network meta-analysis of randomised controlled trials. BMJ 2022;376:e066084.CrossRefGoogle ScholarPubMed
Mavissakalian, M, Perel, JM. Clinical experiments in maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. Archives of General Psychiatry 1992;49(4):318–23.CrossRefGoogle ScholarPubMed
Chen, MH, Tsai, SJ. Treatment-resistant panic disorder: clinical significance, concept and management. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2016;70:219–26.CrossRefGoogle ScholarPubMed
Bandelow, B, Wedekind, D. Internet psychotherapeutic interventions for anxiety disorders – a critical evaluation. BMC Psychiatry 2022;22(1):441.CrossRefGoogle ScholarPubMed
Bandelow, B, Sagebiel, A, Belz, M, et al. Enduring effects of psychological treatments for anxiety disorders: meta-analysis of follow-up studies. British Journal of Psychiatry 2018;212(6):333–38.CrossRefGoogle ScholarPubMed
Schneier, FR, Moskow, DM, Choo, TH, et al. A randomized controlled pilot trial of vilazodone for adult separation anxiety disorder. Depression and Anxiety 2017;34(12):1085–95.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Baldwin, DS. Monoamine oxidase inhibitors (MAOIs) in psychiatric practice: how to use them safely and effectively. CNS Drugs 2021;35(7):703–16.CrossRefGoogle ScholarPubMed
Pollack, MH, Van Ameringen, M, Simon, NM, et al. A double-blind randomized controlled trial of augmentation and switch strategies for refractory social anxiety disorder. American Journal of Psychiatry 2014;171(1):4453.CrossRefGoogle ScholarPubMed
Sartori, SB, Singewald, N. Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders. Pharmacology & Therapeutics 2019;204:107402.CrossRefGoogle ScholarPubMed
Vollmer, LL, Strawn, JR, Sah, R. Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update. Transl Psychiatry 2015;5(5):e572.CrossRefGoogle ScholarPubMed
Vullo, S, Kellenberger, S. A molecular view of the function and pharmacology of acid-sensing ion channels. Pharmacol Res 2020;154:104166.CrossRefGoogle ScholarPubMed
Salvadore, G, Bonaventure, P, Shekhar, A, et al. Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans. Translational Psychiatry 2020;10(1):308.CrossRefGoogle Scholar
Fagan, HA, Huneke, NTM, Domschke, K, Baldwin, DS. The role of the orexin system in the neurobiology of anxiety disorders: potential for a novel treatment target. Neuroscience Applied 2024;3:103922.CrossRefGoogle Scholar
Maramai, S, Benchekroun, M, Ward, SE, et al. Subtype selective γ-aminobutyric acid type A receptor (GABA. Journal of Medicinal Chemistry 2020;63(7):3425–46.CrossRefGoogle ScholarPubMed
Black, N, Stockings, E, Campbell, G, et al. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. Lancet Psychiatry 2019;6(12):9951010.CrossRefGoogle ScholarPubMed
Weston, NM, Gibbs, D, Bird, CIV, et al. Historic psychedelic drug trials and the treatment of anxiety disorders. Depression and Anxiety 2020;37(12):1261–79.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×